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Gene: TRIM71 |
Gene summary for TRIM71 |
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Gene information | Species | Human | Gene symbol | TRIM71 | Gene ID | 131405 |
Gene name | tripartite motif containing 71 | |
Gene Alias | HYDCC1 | |
Cytomap | 3p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q2Q1W2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131405 | TRIM71 | HCC1_Meng | Human | Liver | HCC | 9.66e-39 | 1.87e-01 | 0.0246 |
131405 | TRIM71 | HCC1 | Human | Liver | HCC | 5.09e-08 | 2.37e+00 | 0.5336 |
131405 | TRIM71 | HCC2 | Human | Liver | HCC | 1.30e-15 | 3.34e+00 | 0.5341 |
131405 | TRIM71 | Pt14.a | Human | Liver | HCC | 6.65e-08 | 3.05e-01 | 0.0169 |
131405 | TRIM71 | S014 | Human | Liver | HCC | 2.64e-07 | 2.40e-01 | 0.2254 |
131405 | TRIM71 | S015 | Human | Liver | HCC | 2.91e-14 | 4.85e-01 | 0.2375 |
131405 | TRIM71 | S016 | Human | Liver | HCC | 3.39e-08 | 2.35e-01 | 0.2243 |
131405 | TRIM71 | S028 | Human | Liver | HCC | 1.64e-05 | 1.79e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
GO:003133122 | Liver | HCC | positive regulation of cellular catabolic process | 295/7958 | 427/18723 | 3.20e-29 | 1.45e-26 | 295 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:000640221 | Liver | HCC | mRNA catabolic process | 169/7958 | 232/18723 | 4.50e-21 | 6.96e-19 | 169 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:004348721 | Liver | HCC | regulation of RNA stability | 119/7958 | 170/18723 | 3.20e-13 | 1.71e-11 | 119 |
GO:004348821 | Liver | HCC | regulation of mRNA stability | 110/7958 | 158/18723 | 4.36e-12 | 1.93e-10 | 110 |
GO:006101321 | Liver | HCC | regulation of mRNA catabolic process | 114/7958 | 166/18723 | 7.38e-12 | 3.12e-10 | 114 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:190331321 | Liver | HCC | positive regulation of mRNA metabolic process | 85/7958 | 118/18723 | 7.10e-11 | 2.56e-09 | 85 |
GO:00447722 | Liver | HCC | mitotic cell cycle phase transition | 240/7958 | 424/18723 | 2.47e-09 | 6.84e-08 | 240 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM71 | SNV | Missense_Mutation | novel | c.2470N>C | p.Asn824His | p.N824H | Q2Q1W2 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
TRIM71 | SNV | Missense_Mutation | c.1975G>A | p.Val659Met | p.V659M | Q2Q1W2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM71 | SNV | Missense_Mutation | c.1378N>G | p.Met460Val | p.M460V | Q2Q1W2 | protein_coding | tolerated(0.47) | benign(0.005) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM71 | SNV | Missense_Mutation | c.2303A>G | p.Asn768Ser | p.N768S | Q2Q1W2 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TRIM71 | SNV | Missense_Mutation | c.2344N>T | p.Arg782Cys | p.R782C | Q2Q1W2 | protein_coding | tolerated(0.06) | possibly_damaging(0.759) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TRIM71 | SNV | Missense_Mutation | c.86N>T | p.Ser29Leu | p.S29L | Q2Q1W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.953) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRIM71 | SNV | Missense_Mutation | novel | c.1780N>A | p.Leu594Met | p.L594M | Q2Q1W2 | protein_coding | tolerated(0.13) | benign(0.038) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM71 | SNV | Missense_Mutation | c.1148N>G | p.Leu383Arg | p.L383R | Q2Q1W2 | protein_coding | deleterious(0) | possibly_damaging(0.74) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
TRIM71 | SNV | Missense_Mutation | c.2573T>C | p.Val858Ala | p.V858A | Q2Q1W2 | protein_coding | deleterious(0) | benign(0.426) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TRIM71 | SNV | Missense_Mutation | c.2243N>T | p.Asp748Val | p.D748V | Q2Q1W2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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