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Gene: TRIM14 |
Gene summary for TRIM14 |
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Gene information | Species | Human | Gene symbol | TRIM14 | Gene ID | 9830 |
Gene name | tripartite motif containing 14 | |
Gene Alias | TRIM14 | |
Cytomap | 9q22.33 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0A024R165 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9830 | TRIM14 | CCI_2 | Human | Cervix | CC | 3.86e-03 | 5.85e-01 | 0.5249 |
9830 | TRIM14 | CCI_3 | Human | Cervix | CC | 5.15e-09 | 7.38e-01 | 0.516 |
9830 | TRIM14 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.31e-12 | 5.40e-01 | -0.1954 |
9830 | TRIM14 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.00e-02 | 2.96e-01 | -0.1526 |
9830 | TRIM14 | F007 | Human | Colorectum | FAP | 4.30e-02 | -2.85e-01 | 0.1176 |
9830 | TRIM14 | A015-C-203 | Human | Colorectum | FAP | 2.25e-08 | -2.36e-01 | -0.1294 |
9830 | TRIM14 | A014-C-040 | Human | Colorectum | FAP | 2.62e-02 | -3.40e-01 | -0.1184 |
9830 | TRIM14 | A002-C-201 | Human | Colorectum | FAP | 2.72e-06 | -2.62e-01 | 0.0324 |
9830 | TRIM14 | A001-C-119 | Human | Colorectum | FAP | 2.92e-03 | -2.88e-01 | -0.1557 |
9830 | TRIM14 | A001-C-108 | Human | Colorectum | FAP | 1.50e-06 | -2.37e-01 | -0.0272 |
9830 | TRIM14 | A002-C-205 | Human | Colorectum | FAP | 4.44e-09 | -3.02e-01 | -0.1236 |
9830 | TRIM14 | A001-C-104 | Human | Colorectum | FAP | 2.15e-06 | -2.63e-01 | 0.0184 |
9830 | TRIM14 | A015-C-006 | Human | Colorectum | FAP | 1.45e-03 | -2.17e-01 | -0.0994 |
9830 | TRIM14 | A015-C-106 | Human | Colorectum | FAP | 9.23e-05 | -1.37e-01 | -0.0511 |
9830 | TRIM14 | A002-C-114 | Human | Colorectum | FAP | 4.15e-07 | -2.88e-01 | -0.1561 |
9830 | TRIM14 | A015-C-104 | Human | Colorectum | FAP | 1.17e-09 | -2.21e-01 | -0.1899 |
9830 | TRIM14 | A001-C-014 | Human | Colorectum | FAP | 6.89e-06 | -2.21e-01 | 0.0135 |
9830 | TRIM14 | A002-C-016 | Human | Colorectum | FAP | 2.76e-11 | -2.50e-01 | 0.0521 |
9830 | TRIM14 | A015-C-002 | Human | Colorectum | FAP | 3.57e-03 | -2.66e-01 | -0.0763 |
9830 | TRIM14 | A001-C-203 | Human | Colorectum | FAP | 8.35e-07 | -2.11e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:005212610 | Cervix | CC | movement in host environment | 52/2311 | 175/18723 | 7.03e-10 | 8.76e-08 | 52 |
GO:004440910 | Cervix | CC | entry into host | 47/2311 | 151/18723 | 8.45e-10 | 1.03e-07 | 47 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:004671810 | Cervix | CC | viral entry into host cell | 44/2311 | 144/18723 | 5.47e-09 | 5.03e-07 | 44 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00431228 | Cervix | CC | regulation of I-kappaB kinase/NF-kappaB signaling | 53/2311 | 249/18723 | 4.50e-05 | 6.87e-04 | 53 |
GO:005079210 | Cervix | CC | regulation of viral process | 38/2311 | 164/18723 | 8.12e-05 | 1.10e-03 | 38 |
GO:00072497 | Cervix | CC | I-kappaB kinase/NF-kappaB signaling | 56/2311 | 281/18723 | 1.81e-04 | 2.12e-03 | 56 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:190390010 | Cervix | CC | regulation of viral life cycle | 33/2311 | 148/18723 | 4.86e-04 | 4.76e-03 | 33 |
GO:00510915 | Cervix | CC | positive regulation of DNA-binding transcription factor activity | 51/2311 | 260/18723 | 5.05e-04 | 4.92e-03 | 51 |
GO:00523728 | Cervix | CC | modulation by symbiont of entry into host | 15/2311 | 49/18723 | 5.81e-04 | 5.52e-03 | 15 |
GO:00485256 | Cervix | CC | negative regulation of viral process | 23/2311 | 92/18723 | 6.39e-04 | 5.97e-03 | 23 |
GO:004390310 | Cervix | CC | regulation of biological process involved in symbiotic interaction | 19/2311 | 72/18723 | 9.11e-04 | 7.81e-03 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM14 | SNV | Missense_Mutation | novel | c.287N>T | p.Ala96Val | p.A96V | Q14142 | protein_coding | deleterious(0.02) | benign(0.066) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIM14 | SNV | Missense_Mutation | c.390N>T | p.Lys130Asn | p.K130N | Q14142 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TRIM14 | SNV | Missense_Mutation | novel | c.1100A>G | p.Tyr367Cys | p.Y367C | Q14142 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
TRIM14 | SNV | Missense_Mutation | c.779C>T | p.Ser260Leu | p.S260L | Q14142 | protein_coding | tolerated(0.81) | benign(0.006) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM14 | SNV | Missense_Mutation | rs149392923 | c.622G>A | p.Val208Ile | p.V208I | Q14142 | protein_coding | tolerated(0.48) | benign(0) | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TRIM14 | SNV | Missense_Mutation | novel | c.776G>A | p.Arg259Gln | p.R259Q | Q14142 | protein_coding | deleterious(0.04) | probably_damaging(0.965) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
TRIM14 | SNV | Missense_Mutation | c.89N>T | p.Arg30Leu | p.R30L | Q14142 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM14 | SNV | Missense_Mutation | novel | c.472N>T | p.Met158Leu | p.M158L | Q14142 | protein_coding | tolerated(1) | benign(0) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
TRIM14 | SNV | Missense_Mutation | c.58T>C | p.Cys20Arg | p.C20R | Q14142 | protein_coding | tolerated(0.39) | benign(0) | TCGA-18-4086-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM14 | deletion | Frame_Shift_Del | c.37delA | p.Arg13GlyfsTer64 | p.R13Gfs*64 | Q14142 | protein_coding | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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