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Gene: TRAF5 |
Gene summary for TRAF5 |
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Gene information | Species | Human | Gene symbol | TRAF5 | Gene ID | 7188 |
Gene name | TNF receptor associated factor 5 | |
Gene Alias | MGC:39780 | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O00463 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7188 | TRAF5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.08e-02 | 3.76e-01 | 0.294 |
7188 | TRAF5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.08e-04 | 4.67e-01 | 0.281 |
7188 | TRAF5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.35e-08 | 6.71e-01 | 0.3859 |
7188 | TRAF5 | A002-C-010 | Human | Colorectum | FAP | 1.12e-03 | 3.72e-01 | 0.242 |
7188 | TRAF5 | A015-C-203 | Human | Colorectum | FAP | 1.00e-14 | 2.61e-01 | -0.1294 |
7188 | TRAF5 | A002-C-201 | Human | Colorectum | FAP | 2.54e-07 | 3.42e-01 | 0.0324 |
7188 | TRAF5 | A001-C-108 | Human | Colorectum | FAP | 2.32e-07 | 3.64e-01 | -0.0272 |
7188 | TRAF5 | A002-C-021 | Human | Colorectum | FAP | 8.51e-13 | 5.75e-01 | 0.1171 |
7188 | TRAF5 | A002-C-205 | Human | Colorectum | FAP | 2.70e-08 | 1.18e-01 | -0.1236 |
7188 | TRAF5 | A001-C-104 | Human | Colorectum | FAP | 3.64e-07 | 4.42e-01 | 0.0184 |
7188 | TRAF5 | A015-C-005 | Human | Colorectum | FAP | 9.55e-03 | 3.79e-01 | -0.0336 |
7188 | TRAF5 | A015-C-006 | Human | Colorectum | FAP | 5.99e-06 | 1.48e-01 | -0.0994 |
7188 | TRAF5 | A015-C-106 | Human | Colorectum | FAP | 8.96e-06 | 3.78e-01 | -0.0511 |
7188 | TRAF5 | A002-C-114 | Human | Colorectum | FAP | 1.97e-06 | 1.24e-01 | -0.1561 |
7188 | TRAF5 | A015-C-104 | Human | Colorectum | FAP | 1.17e-15 | 2.83e-01 | -0.1899 |
7188 | TRAF5 | A001-C-014 | Human | Colorectum | FAP | 2.48e-09 | 3.84e-01 | 0.0135 |
7188 | TRAF5 | A002-C-016 | Human | Colorectum | FAP | 6.60e-07 | 2.04e-01 | 0.0521 |
7188 | TRAF5 | A015-C-002 | Human | Colorectum | FAP | 4.84e-03 | 1.57e-01 | -0.0763 |
7188 | TRAF5 | A001-C-203 | Human | Colorectum | FAP | 1.73e-03 | 2.65e-01 | -0.0481 |
7188 | TRAF5 | A002-C-116 | Human | Colorectum | FAP | 1.73e-11 | 1.33e-02 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19033112 | Colorectum | MSS | regulation of mRNA metabolic process | 115/3467 | 288/18723 | 1.23e-17 | 6.41e-15 | 115 |
GO:00064012 | Colorectum | MSS | RNA catabolic process | 102/3467 | 278/18723 | 5.07e-13 | 1.02e-10 | 102 |
GO:00064022 | Colorectum | MSS | mRNA catabolic process | 89/3467 | 232/18723 | 8.70e-13 | 1.60e-10 | 89 |
GO:00313302 | Colorectum | MSS | negative regulation of cellular catabolic process | 96/3467 | 262/18723 | 2.67e-12 | 4.63e-10 | 96 |
GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:00346552 | Colorectum | MSS | nucleobase-containing compound catabolic process | 129/3467 | 407/18723 | 7.48e-11 | 8.18e-09 | 129 |
GO:00610132 | Colorectum | MSS | regulation of mRNA catabolic process | 66/3467 | 166/18723 | 1.25e-10 | 1.26e-08 | 66 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00434872 | Colorectum | MSS | regulation of RNA stability | 66/3467 | 170/18723 | 4.14e-10 | 3.49e-08 | 66 |
GO:00434882 | Colorectum | MSS | regulation of mRNA stability | 62/3467 | 158/18723 | 8.41e-10 | 6.81e-08 | 62 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:19033122 | Colorectum | MSS | negative regulation of mRNA metabolic process | 37/3467 | 92/18723 | 1.00e-06 | 3.46e-05 | 37 |
GO:19023691 | Colorectum | MSS | negative regulation of RNA catabolic process | 32/3467 | 75/18723 | 1.14e-06 | 3.87e-05 | 32 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:00434891 | Colorectum | MSS | RNA stabilization | 26/3467 | 65/18723 | 4.39e-05 | 8.17e-04 | 26 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:19023731 | Colorectum | MSS | negative regulation of mRNA catabolic process | 25/3467 | 63/18723 | 7.15e-05 | 1.21e-03 | 25 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051634 | Colorectum | MSS | Human cytomegalovirus infection | 74/1875 | 225/8465 | 1.12e-04 | 1.01e-03 | 6.19e-04 | 74 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa05169 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa05222 | Colorectum | MSS | Small cell lung cancer | 30/1875 | 92/8465 | 1.31e-02 | 4.30e-02 | 2.64e-02 | 30 |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051635 | Colorectum | MSS | Human cytomegalovirus infection | 74/1875 | 225/8465 | 1.12e-04 | 1.01e-03 | 6.19e-04 | 74 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa051691 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa052221 | Colorectum | MSS | Small cell lung cancer | 30/1875 | 92/8465 | 1.31e-02 | 4.30e-02 | 2.64e-02 | 30 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051636 | Colorectum | FAP | Human cytomegalovirus infection | 55/1404 | 225/8465 | 1.42e-03 | 7.67e-03 | 4.67e-03 | 55 |
hsa051706 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa052222 | Colorectum | FAP | Small cell lung cancer | 24/1404 | 92/8465 | 1.33e-02 | 4.46e-02 | 2.71e-02 | 24 |
hsa051319 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa051637 | Colorectum | FAP | Human cytomegalovirus infection | 55/1404 | 225/8465 | 1.42e-03 | 7.67e-03 | 4.67e-03 | 55 |
hsa051707 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa052223 | Colorectum | FAP | Small cell lung cancer | 24/1404 | 92/8465 | 1.33e-02 | 4.46e-02 | 2.71e-02 | 24 |
hsa051638 | Colorectum | CRC | Human cytomegalovirus infection | 45/1091 | 225/8465 | 1.54e-03 | 1.17e-02 | 7.94e-03 | 45 |
hsa051639 | Colorectum | CRC | Human cytomegalovirus infection | 45/1091 | 225/8465 | 1.54e-03 | 1.17e-02 | 7.94e-03 | 45 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAF5 | SNV | Missense_Mutation | rs373368870 | c.1178G>A | p.Arg393Gln | p.R393Q | O00463 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRAF5 | SNV | Missense_Mutation | c.302N>T | p.Arg101Ile | p.R101I | O00463 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TRAF5 | SNV | Missense_Mutation | rs765593941 | c.491N>T | p.Arg164Leu | p.R164L | O00463 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRAF5 | SNV | Missense_Mutation | rs113925874 | c.695C>T | p.Thr232Met | p.T232M | O00463 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
TRAF5 | SNV | Missense_Mutation | c.884T>C | p.Phe295Ser | p.F295S | O00463 | protein_coding | tolerated(0.07) | benign(0.042) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRAF5 | SNV | Missense_Mutation | novel | c.1417C>A | p.Leu473Met | p.L473M | O00463 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRAF5 | SNV | Missense_Mutation | novel | c.1632N>A | p.Phe544Leu | p.F544L | O00463 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRAF5 | SNV | Missense_Mutation | c.1472N>A | p.Gly491Asp | p.G491D | O00463 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRAF5 | SNV | Missense_Mutation | novel | c.1529N>A | p.Arg510Lys | p.R510K | O00463 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAF5 | SNV | Missense_Mutation | novel | c.51G>T | p.Gln17His | p.Q17H | O00463 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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