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Gene: TRAF3IP1 |
Gene summary for TRAF3IP1 |
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Gene information | Species | Human | Gene symbol | TRAF3IP1 | Gene ID | 26146 |
Gene name | TRAF3 interacting protein 1 | |
Gene Alias | FAP116 | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8TDR0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26146 | TRAF3IP1 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 9.89e-02 | 0.067 |
26146 | TRAF3IP1 | LZE24T | Human | Esophagus | ESCC | 3.17e-06 | 1.92e-01 | 0.0596 |
26146 | TRAF3IP1 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 1.72e-01 | 0.0655 |
26146 | TRAF3IP1 | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 1.88e-01 | 0.0875 |
26146 | TRAF3IP1 | P2T-E | Human | Esophagus | ESCC | 2.05e-09 | 1.94e-01 | 0.1177 |
26146 | TRAF3IP1 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.29e-01 | 0.1323 |
26146 | TRAF3IP1 | P5T-E | Human | Esophagus | ESCC | 8.96e-04 | 5.62e-02 | 0.1327 |
26146 | TRAF3IP1 | P8T-E | Human | Esophagus | ESCC | 3.77e-07 | 1.62e-01 | 0.0889 |
26146 | TRAF3IP1 | P10T-E | Human | Esophagus | ESCC | 2.00e-09 | 1.15e-01 | 0.116 |
26146 | TRAF3IP1 | P12T-E | Human | Esophagus | ESCC | 6.12e-07 | 1.58e-01 | 0.1122 |
26146 | TRAF3IP1 | P15T-E | Human | Esophagus | ESCC | 2.22e-12 | 2.18e-01 | 0.1149 |
26146 | TRAF3IP1 | P16T-E | Human | Esophagus | ESCC | 1.00e-06 | 1.24e-01 | 0.1153 |
26146 | TRAF3IP1 | P20T-E | Human | Esophagus | ESCC | 1.04e-10 | 1.86e-01 | 0.1124 |
26146 | TRAF3IP1 | P21T-E | Human | Esophagus | ESCC | 6.41e-08 | 1.85e-01 | 0.1617 |
26146 | TRAF3IP1 | P22T-E | Human | Esophagus | ESCC | 2.30e-06 | 1.56e-01 | 0.1236 |
26146 | TRAF3IP1 | P23T-E | Human | Esophagus | ESCC | 1.83e-07 | 1.66e-01 | 0.108 |
26146 | TRAF3IP1 | P24T-E | Human | Esophagus | ESCC | 1.10e-04 | 1.42e-01 | 0.1287 |
26146 | TRAF3IP1 | P26T-E | Human | Esophagus | ESCC | 1.28e-05 | 9.12e-02 | 0.1276 |
26146 | TRAF3IP1 | P27T-E | Human | Esophagus | ESCC | 1.40e-05 | 1.36e-01 | 0.1055 |
26146 | TRAF3IP1 | P28T-E | Human | Esophagus | ESCC | 1.45e-20 | 4.65e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:00017387 | Esophagus | ESCC | morphogenesis of a polarized epithelium | 63/8552 | 94/18723 | 2.34e-05 | 2.00e-04 | 63 |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:0031333110 | Esophagus | ESCC | negative regulation of protein-containing complex assembly | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:003247912 | Esophagus | ESCC | regulation of type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:003260612 | Esophagus | ESCC | type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAF3IP1 | deletion | Frame_Shift_Del | c.762delN | p.Glu258ArgfsTer5 | p.E258Rfs*5 | Q8TDR0 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
TRAF3IP1 | deletion | Frame_Shift_Del | c.762delN | p.Glu258ArgfsTer5 | p.E258Rfs*5 | Q8TDR0 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TRAF3IP1 | SNV | Missense_Mutation | novel | c.205N>G | p.Lys69Glu | p.K69E | Q8TDR0 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRAF3IP1 | SNV | Missense_Mutation | novel | c.2004N>T | p.Lys668Asn | p.K668N | Q8TDR0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRAF3IP1 | SNV | Missense_Mutation | c.637N>G | p.Arg213Gly | p.R213G | Q8TDR0 | protein_coding | deleterious(0) | possibly_damaging(0.537) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRAF3IP1 | SNV | Missense_Mutation | c.839N>A | p.Arg280Gln | p.R280Q | Q8TDR0 | protein_coding | tolerated(0.51) | benign(0.04) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
TRAF3IP1 | SNV | Missense_Mutation | c.171N>T | p.Glu57Asp | p.E57D | Q8TDR0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRAF3IP1 | SNV | Missense_Mutation | novel | c.545N>A | p.Arg182Gln | p.R182Q | Q8TDR0 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAF3IP1 | SNV | Missense_Mutation | c.1536N>C | p.Glu512Asp | p.E512D | Q8TDR0 | protein_coding | deleterious(0.02) | possibly_damaging(0.695) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRAF3IP1 | SNV | Missense_Mutation | c.615G>T | p.Lys205Asn | p.K205N | Q8TDR0 | protein_coding | tolerated(0.15) | benign(0.037) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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