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Gene: TPPP3 |
Gene summary for TPPP3 |
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Gene information | Species | Human | Gene symbol | TPPP3 | Gene ID | 51673 |
Gene name | tubulin polymerization promoting protein family member 3 | |
Gene Alias | CGI-38 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R702 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51673 | TPPP3 | LZE4T | Human | Esophagus | ESCC | 1.21e-09 | 5.24e-01 | 0.0811 |
51673 | TPPP3 | LZE8T | Human | Esophagus | ESCC | 2.75e-07 | 4.37e-01 | 0.067 |
51673 | TPPP3 | P8T-E | Human | Esophagus | ESCC | 3.53e-16 | 7.37e-01 | 0.0889 |
51673 | TPPP3 | P11T-E | Human | Esophagus | ESCC | 8.31e-06 | 5.60e-01 | 0.1426 |
51673 | TPPP3 | P19T-E | Human | Esophagus | ESCC | 2.85e-03 | 9.25e-01 | 0.1662 |
51673 | TPPP3 | P21T-E | Human | Esophagus | ESCC | 2.85e-64 | 2.58e+00 | 0.1617 |
51673 | TPPP3 | P22T-E | Human | Esophagus | ESCC | 1.06e-04 | -2.01e-02 | 0.1236 |
51673 | TPPP3 | P23T-E | Human | Esophagus | ESCC | 1.02e-06 | 3.42e-01 | 0.108 |
51673 | TPPP3 | P26T-E | Human | Esophagus | ESCC | 2.00e-09 | 3.73e-01 | 0.1276 |
51673 | TPPP3 | P31T-E | Human | Esophagus | ESCC | 5.34e-56 | 1.71e+00 | 0.1251 |
51673 | TPPP3 | P48T-E | Human | Esophagus | ESCC | 8.61e-12 | 4.29e-01 | 0.0959 |
51673 | TPPP3 | P54T-E | Human | Esophagus | ESCC | 1.43e-05 | 5.18e-01 | 0.0975 |
51673 | TPPP3 | P74T-E | Human | Esophagus | ESCC | 1.81e-15 | 5.08e-01 | 0.1479 |
51673 | TPPP3 | P82T-E | Human | Esophagus | ESCC | 1.05e-06 | 8.41e-01 | 0.1072 |
51673 | TPPP3 | P89T-E | Human | Esophagus | ESCC | 1.93e-08 | 1.32e+00 | 0.1752 |
51673 | TPPP3 | P91T-E | Human | Esophagus | ESCC | 5.45e-04 | 1.91e+00 | 0.1828 |
51673 | TPPP3 | P104T-E | Human | Esophagus | ESCC | 7.85e-07 | 5.36e-01 | 0.0931 |
51673 | TPPP3 | P107T-E | Human | Esophagus | ESCC | 8.60e-47 | 1.91e+00 | 0.171 |
51673 | TPPP3 | P128T-E | Human | Esophagus | ESCC | 1.70e-02 | 3.08e-01 | 0.1241 |
51673 | TPPP3 | P130T-E | Human | Esophagus | ESCC | 3.14e-22 | 6.49e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
GO:0032273111 | Esophagus | ESCC | positive regulation of protein polymerization | 95/8552 | 138/18723 | 2.97e-08 | 5.57e-07 | 95 |
GO:0001890110 | Esophagus | ESCC | placenta development | 98/8552 | 144/18723 | 4.46e-08 | 8.11e-07 | 98 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:0032271111 | Esophagus | ESCC | regulation of protein polymerization | 143/8552 | 233/18723 | 9.21e-07 | 1.17e-05 | 143 |
GO:00018937 | Esophagus | ESCC | maternal placenta development | 28/8552 | 35/18723 | 3.40e-05 | 2.78e-04 | 28 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00467856 | Esophagus | ESCC | microtubule polymerization | 55/8552 | 83/18723 | 1.21e-04 | 8.31e-04 | 55 |
GO:00466975 | Esophagus | ESCC | decidualization | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:00601357 | Esophagus | ESCC | maternal process involved in female pregnancy | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
GO:00075668 | Esophagus | ESCC | embryo implantation | 35/8552 | 53/18723 | 2.22e-03 | 9.78e-03 | 35 |
GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
GO:005125812 | Liver | Cirrhotic | protein polymerization | 116/4634 | 297/18723 | 2.87e-08 | 9.78e-07 | 116 |
GO:00313347 | Liver | Cirrhotic | positive regulation of protein-containing complex assembly | 95/4634 | 237/18723 | 1.21e-07 | 3.39e-06 | 95 |
GO:003227112 | Liver | Cirrhotic | regulation of protein polymerization | 92/4634 | 233/18723 | 4.25e-07 | 9.86e-06 | 92 |
GO:003227312 | Liver | Cirrhotic | positive regulation of protein polymerization | 58/4634 | 138/18723 | 5.96e-06 | 9.69e-05 | 58 |
GO:00018905 | Liver | Cirrhotic | placenta development | 57/4634 | 144/18723 | 5.74e-05 | 6.58e-04 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPPP3 | SNV | Missense_Mutation | rs146906089 | c.337N>A | p.Val113Ile | p.V113I | Q9BW30 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-FV-A2QQ-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TPPP3 | SNV | Missense_Mutation | novel | c.33G>T | p.Glu11Asp | p.E11D | Q9BW30 | protein_coding | deleterious(0.03) | benign(0.194) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TPPP3 | SNV | Missense_Mutation | rs370550940 | c.202N>T | p.Arg68Trp | p.R68W | Q9BW30 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |
TPPP3 | SNV | Missense_Mutation | novel | c.129N>C | p.Lys43Asn | p.K43N | Q9BW30 | protein_coding | tolerated(0.22) | benign(0.018) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TPPP3 | SNV | Missense_Mutation | rs368634690 | c.418N>A | p.Asp140Asn | p.D140N | Q9BW30 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-D6-8568-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TPPP3 | SNV | Missense_Mutation | rs760629455 | c.8C>T | p.Ala3Val | p.A3V | Q9BW30 | protein_coding | tolerated_low_confidence(0.35) | benign(0) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TPPP3 | SNV | Missense_Mutation | rs372034237 | c.371G>A | p.Arg124Gln | p.R124Q | Q9BW30 | protein_coding | tolerated(0.1) | possibly_damaging(0.702) | TCGA-BR-8380-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | polyplatillen | PD |
TPPP3 | SNV | Missense_Mutation | c.370C>T | p.Arg124Trp | p.R124W | Q9BW30 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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