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Gene: TOR4A |
Gene summary for TOR4A |
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Gene information | Species | Human | Gene symbol | TOR4A | Gene ID | 54863 |
Gene name | torsin family 4 member A | |
Gene Alias | C9orf167 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NXH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54863 | TOR4A | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.47e-04 | 1.59e-01 | 0.0155 |
54863 | TOR4A | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.63e-16 | 5.31e-01 | -0.1808 |
54863 | TOR4A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.57e-17 | 6.70e-01 | -0.0811 |
54863 | TOR4A | HTA11_78_2000001011 | Human | Colorectum | AD | 1.40e-05 | 3.09e-01 | -0.1088 |
54863 | TOR4A | HTA11_347_2000001011 | Human | Colorectum | AD | 8.06e-15 | 3.35e-01 | -0.1954 |
54863 | TOR4A | HTA11_411_2000001011 | Human | Colorectum | SER | 2.39e-06 | 8.99e-01 | -0.2602 |
54863 | TOR4A | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.75e-06 | 6.77e-01 | -0.2196 |
54863 | TOR4A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.25e-03 | 2.79e-01 | -0.1207 |
54863 | TOR4A | HTA11_83_2000001011 | Human | Colorectum | SER | 2.20e-06 | 4.47e-01 | -0.1526 |
54863 | TOR4A | HTA11_696_2000001011 | Human | Colorectum | AD | 5.16e-20 | 3.98e-01 | -0.1464 |
54863 | TOR4A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.47e-12 | 2.48e-01 | -0.1001 |
54863 | TOR4A | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.54e-29 | 8.31e-01 | -0.059 |
54863 | TOR4A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.66e-03 | 2.45e-01 | -0.0842 |
54863 | TOR4A | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.58e-05 | 2.92e-01 | -0.0179 |
54863 | TOR4A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.34e-12 | 3.80e-01 | 0.096 |
54863 | TOR4A | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.51e-08 | 4.63e-01 | 0.0528 |
54863 | TOR4A | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.59e-04 | 5.55e-01 | 0.0131 |
54863 | TOR4A | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.71e-02 | 2.52e-01 | -0.0177 |
54863 | TOR4A | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.02e-05 | 4.92e-01 | 0.0171 |
54863 | TOR4A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.18e-03 | 2.46e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOR4A | SNV | Missense_Mutation | novel | c.1204N>T | p.Arg402Cys | p.R402C | Q9NXH8 | protein_coding | deleterious(0.05) | benign(0.332) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TOR4A | SNV | Missense_Mutation | novel | c.391G>T | p.Gly131Cys | p.G131C | Q9NXH8 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-58-A46N-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TOR4A | SNV | Missense_Mutation | novel | c.887N>G | p.Tyr296Cys | p.Y296C | Q9NXH8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-77-8153-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOR4A | SNV | Missense_Mutation | novel | c.1195N>T | p.Ser399Cys | p.S399C | Q9NXH8 | protein_coding | deleterious(0.03) | possibly_damaging(0.846) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TOR4A | SNV | Missense_Mutation | c.889G>A | p.Val297Met | p.V297M | Q9NXH8 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-CR-6487-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOR4A | SNV | Missense_Mutation | novel | c.979N>T | p.Arg327Cys | p.R327C | Q9NXH8 | protein_coding | tolerated(0.2) | benign(0.2) | TCGA-CV-7413-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOR4A | SNV | Missense_Mutation | novel | c.334C>T | p.Arg112Cys | p.R112C | Q9NXH8 | protein_coding | deleterious(0.02) | possibly_damaging(0.535) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TOR4A | SNV | Missense_Mutation | c.923C>T | p.Thr308Met | p.T308M | Q9NXH8 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOR4A | SNV | Missense_Mutation | novel | c.818G>A | p.Arg273Gln | p.R273Q | Q9NXH8 | protein_coding | tolerated(0.13) | benign(0) | TCGA-BR-8362-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
TOR4A | SNV | Missense_Mutation | c.434C>T | p.Ala145Val | p.A145V | Q9NXH8 | protein_coding | tolerated(1) | benign(0.05) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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