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Gene: TOM1 |
Gene summary for TOM1 |
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Gene information | Species | Human | Gene symbol | TOM1 | Gene ID | 10043 |
Gene name | target of myb1 membrane trafficking protein | |
Gene Alias | IMD85 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KUF5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10043 | TOM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-07 | 4.15e-01 | -0.1808 |
10043 | TOM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.05e-07 | 3.10e-01 | -0.0811 |
10043 | TOM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.73e-09 | 2.84e-01 | -0.1954 |
10043 | TOM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.64e-03 | 6.62e-01 | -0.2602 |
10043 | TOM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.03e-04 | 3.26e-01 | -0.1207 |
10043 | TOM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-07 | 2.84e-01 | -0.1464 |
10043 | TOM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.05e-02 | 1.59e-01 | -0.1001 |
10043 | TOM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.37e-11 | 4.71e-01 | -0.059 |
10043 | TOM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.29e-02 | 1.55e-01 | 0.096 |
10043 | TOM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.01e-07 | 4.10e-01 | 0.3859 |
10043 | TOM1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.23e-06 | 4.18e-01 | 0.2585 |
10043 | TOM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.47e-04 | 1.55e-01 | 0.3005 |
10043 | TOM1 | LZE4T | Human | Esophagus | ESCC | 3.05e-07 | 2.63e-01 | 0.0811 |
10043 | TOM1 | LZE5T | Human | Esophagus | ESCC | 1.20e-02 | 2.45e-01 | 0.0514 |
10043 | TOM1 | LZE7T | Human | Esophagus | ESCC | 1.52e-02 | 3.04e-01 | 0.0667 |
10043 | TOM1 | LZE8T | Human | Esophagus | ESCC | 2.60e-04 | 1.59e-01 | 0.067 |
10043 | TOM1 | LZE20T | Human | Esophagus | ESCC | 6.59e-07 | 2.79e-01 | 0.0662 |
10043 | TOM1 | LZE24T | Human | Esophagus | ESCC | 4.21e-15 | 3.99e-01 | 0.0596 |
10043 | TOM1 | LZE6T | Human | Esophagus | ESCC | 4.51e-03 | 2.33e-01 | 0.0845 |
10043 | TOM1 | P1T-E | Human | Esophagus | ESCC | 2.64e-09 | 7.38e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:00457862 | Cervix | CC | negative regulation of cell cycle | 67/2311 | 385/18723 | 2.21e-03 | 1.59e-02 | 67 |
GO:00459302 | Cervix | CC | negative regulation of mitotic cell cycle | 44/2311 | 235/18723 | 3.02e-03 | 1.99e-02 | 44 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00109482 | Cervix | CC | negative regulation of cell cycle process | 51/2311 | 294/18723 | 7.35e-03 | 3.94e-02 | 51 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00106392 | Colorectum | MSS | negative regulation of organelle organization | 102/3467 | 348/18723 | 5.36e-07 | 2.05e-05 | 102 |
GO:00336742 | Colorectum | MSS | positive regulation of kinase activity | 122/3467 | 467/18723 | 2.50e-05 | 5.21e-04 | 122 |
GO:00458602 | Colorectum | MSS | positive regulation of protein kinase activity | 102/3467 | 386/18723 | 6.93e-05 | 1.20e-03 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOM1 | SNV | Missense_Mutation | c.782N>A | p.Cys261Tyr | p.C261Y | O60784 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A03F-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TOM1 | SNV | Missense_Mutation | c.689A>G | p.Asn230Ser | p.N230S | O60784 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOM1 | SNV | Missense_Mutation | novel | c.455C>G | p.Pro152Arg | p.P152R | O60784 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TOM1 | SNV | Missense_Mutation | rs759085181 | c.1205N>A | p.Arg402Gln | p.R402Q | O60784 | protein_coding | tolerated(0.08) | probably_damaging(0.921) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TOM1 | SNV | Missense_Mutation | c.782N>A | p.Cys261Tyr | p.C261Y | O60784 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOM1 | SNV | Missense_Mutation | rs757629430 | c.1223C>T | p.Ala408Val | p.A408V | O60784 | protein_coding | tolerated(0.19) | probably_damaging(0.989) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOM1 | SNV | Missense_Mutation | novel | c.664N>C | p.Ser222Arg | p.S222R | O60784 | protein_coding | tolerated(0.09) | benign(0.045) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOM1 | SNV | Missense_Mutation | novel | c.1285N>T | p.Gly429Cys | p.G429C | O60784 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOM1 | SNV | Missense_Mutation | novel | c.32N>T | p.Ser11Phe | p.S11F | O60784 | protein_coding | deleterious(0) | possibly_damaging(0.642) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOM1 | SNV | Missense_Mutation | c.295N>A | p.Leu99Met | p.L99M | O60784 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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