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Gene: TNK2 |
Gene summary for TNK2 |
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Gene information | Species | Human | Gene symbol | TNK2 | Gene ID | 10188 |
Gene name | tyrosine kinase non receptor 2 | |
Gene Alias | ACK | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q07912 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10188 | TNK2 | CCI_1 | Human | Cervix | CC | 6.20e-04 | 5.38e-01 | 0.528 |
10188 | TNK2 | CCI_3 | Human | Cervix | CC | 5.14e-04 | 4.73e-01 | 0.516 |
10188 | TNK2 | CCII_1 | Human | Cervix | CC | 1.31e-03 | 2.97e-01 | 0.3249 |
10188 | TNK2 | LZE20T | Human | Esophagus | ESCC | 1.04e-02 | 7.92e-02 | 0.0662 |
10188 | TNK2 | LZE24T | Human | Esophagus | ESCC | 1.29e-12 | 1.38e-01 | 0.0596 |
10188 | TNK2 | LZE21T | Human | Esophagus | ESCC | 4.30e-06 | 3.26e-01 | 0.0655 |
10188 | TNK2 | P1T-E | Human | Esophagus | ESCC | 1.90e-04 | 3.08e-01 | 0.0875 |
10188 | TNK2 | P2T-E | Human | Esophagus | ESCC | 9.43e-19 | 2.42e-01 | 0.1177 |
10188 | TNK2 | P4T-E | Human | Esophagus | ESCC | 1.46e-10 | 1.10e-01 | 0.1323 |
10188 | TNK2 | P5T-E | Human | Esophagus | ESCC | 1.62e-03 | 5.68e-02 | 0.1327 |
10188 | TNK2 | P8T-E | Human | Esophagus | ESCC | 4.40e-05 | 5.22e-02 | 0.0889 |
10188 | TNK2 | P9T-E | Human | Esophagus | ESCC | 3.52e-08 | 1.81e-01 | 0.1131 |
10188 | TNK2 | P10T-E | Human | Esophagus | ESCC | 8.42e-09 | 1.63e-01 | 0.116 |
10188 | TNK2 | P11T-E | Human | Esophagus | ESCC | 9.44e-08 | 1.82e-01 | 0.1426 |
10188 | TNK2 | P12T-E | Human | Esophagus | ESCC | 1.43e-06 | 1.12e-01 | 0.1122 |
10188 | TNK2 | P15T-E | Human | Esophagus | ESCC | 4.54e-22 | 2.39e-01 | 0.1149 |
10188 | TNK2 | P16T-E | Human | Esophagus | ESCC | 4.37e-07 | 7.12e-02 | 0.1153 |
10188 | TNK2 | P20T-E | Human | Esophagus | ESCC | 5.09e-05 | 5.48e-02 | 0.1124 |
10188 | TNK2 | P21T-E | Human | Esophagus | ESCC | 2.95e-04 | 1.50e-01 | 0.1617 |
10188 | TNK2 | P22T-E | Human | Esophagus | ESCC | 1.74e-12 | 1.29e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00301008 | Cervix | CC | regulation of endocytosis | 47/2311 | 211/18723 | 3.65e-05 | 5.82e-04 | 47 |
GO:00725836 | Cervix | CC | clathrin-dependent endocytosis | 16/2311 | 47/18723 | 9.56e-05 | 1.25e-03 | 16 |
GO:00482597 | Cervix | CC | regulation of receptor-mediated endocytosis | 24/2311 | 110/18723 | 3.62e-03 | 2.31e-02 | 24 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:0001890110 | Esophagus | ESCC | placenta development | 98/8552 | 144/18723 | 4.46e-08 | 8.11e-07 | 98 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:007258314 | Esophagus | ESCC | clathrin-dependent endocytosis | 34/8552 | 47/18723 | 1.91e-04 | 1.21e-03 | 34 |
GO:00352647 | Esophagus | ESCC | multicellular organism growth | 80/8552 | 132/18723 | 3.84e-04 | 2.22e-03 | 80 |
GO:0006646 | Esophagus | ESCC | phosphatidylethanolamine biosynthetic process | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNK2 | SNV | Missense_Mutation | novel | c.2790N>C | p.Lys930Asn | p.K930N | Q07912 | protein_coding | deleterious_low_confidence(0.01) | benign(0.134) | TCGA-VS-A9UP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TNK2 | SNV | Missense_Mutation | rs755481543 | c.1639G>A | p.Glu547Lys | p.E547K | Q07912 | protein_coding | deleterious(0.03) | benign(0.356) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TNK2 | SNV | Missense_Mutation | novel | c.3119N>C | p.Ile1040Thr | p.I1040T | Q07912 | protein_coding | tolerated_low_confidence(0.07) | benign(0.003) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TNK2 | SNV | Missense_Mutation | rs762033031 | c.1057N>T | p.Arg353Cys | p.R353C | Q07912 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TNK2 | SNV | Missense_Mutation | rs747816316 | c.1087G>A | p.Glu363Lys | p.E363K | Q07912 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNK2 | SNV | Missense_Mutation | rs763489801 | c.515N>T | p.Ala172Val | p.A172V | Q07912 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
TNK2 | SNV | Missense_Mutation | c.274N>T | p.Asp92Tyr | p.D92Y | Q07912 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TNK2 | SNV | Missense_Mutation | rs552313951 | c.2716G>A | p.Ala906Thr | p.A906T | Q07912 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.886) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TNK2 | SNV | Missense_Mutation | c.1062N>T | p.Lys354Asn | p.K354N | Q07912 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNK2 | SNV | Missense_Mutation | c.2759N>T | p.Pro920Leu | p.P920L | Q07912 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.747) | TCGA-QG-A5YX-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | CYC-116 | CYC-116 | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | ILORASERTIB | ILORASERTIB | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | AZD-1775 | ADAVOSERTIB | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | CENISERTIB | CENISERTIB | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | PF-562271 | PF-00562271 | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | inhibitor | 249565873 | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | ZM-447439 | CHEMBL202721 | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | DASATINIB | DASATINIB | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | ALISERTIB | ALISERTIB | ||
10188 | TNK2 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, TYROSINE KINASE, ENZYME | RG-1530 | RG-1530 |
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