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Gene: TNFRSF10D |
Gene summary for TNFRSF10D |
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Gene information | Species | Human | Gene symbol | TNFRSF10D | Gene ID | 8793 |
Gene name | TNF receptor superfamily member 10d | |
Gene Alias | CD264 | |
Cytomap | 8p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9UBN6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8793 | TNFRSF10D | AEH-subject1 | Human | Endometrium | AEH | 2.25e-44 | 9.55e-01 | -0.3059 |
8793 | TNFRSF10D | AEH-subject2 | Human | Endometrium | AEH | 9.08e-12 | 4.56e-01 | -0.2525 |
8793 | TNFRSF10D | AEH-subject3 | Human | Endometrium | AEH | 1.15e-15 | 5.17e-01 | -0.2576 |
8793 | TNFRSF10D | AEH-subject4 | Human | Endometrium | AEH | 1.38e-03 | 2.38e-01 | -0.2657 |
8793 | TNFRSF10D | EEC-subject1 | Human | Endometrium | EEC | 2.44e-07 | 2.29e-01 | -0.2682 |
8793 | TNFRSF10D | EEC-subject2 | Human | Endometrium | EEC | 1.03e-18 | 5.37e-01 | -0.2607 |
8793 | TNFRSF10D | TD9 | Human | Lung | IAC | 8.92e-03 | 6.57e-01 | 0.088 |
8793 | TNFRSF10D | RNA-P17T-P17T-8 | Human | Lung | IAC | 3.92e-04 | 5.71e-01 | 0.3329 |
8793 | TNFRSF10D | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.79e-04 | 5.39e-01 | 0.1829 |
8793 | TNFRSF10D | RNA-P3T-P3T-2 | Human | Lung | IAC | 2.05e-02 | 4.50e-01 | 0.1835 |
8793 | TNFRSF10D | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.14e-04 | 5.47e-01 | 0.1859 |
8793 | TNFRSF10D | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.80e-02 | 2.33e-01 | -0.0166 |
8793 | TNFRSF10D | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.58e-06 | 3.32e-01 | -0.0132 |
8793 | TNFRSF10D | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.25e-02 | 1.95e-01 | -0.013 |
8793 | TNFRSF10D | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.41e-04 | 2.90e-01 | -0.0121 |
8793 | TNFRSF10D | Pat01-B | Human | Stomach | GC | 1.21e-03 | 2.16e-01 | 0.5754 |
8793 | TNFRSF10D | Pat02-B | Human | Stomach | GC | 5.80e-05 | 9.89e-02 | 0.0368 |
8793 | TNFRSF10D | Pat04-B | Human | Stomach | GC | 3.73e-07 | 2.08e-01 | -0.1483 |
8793 | TNFRSF10D | Pat05-B | Human | Stomach | GC | 1.00e-04 | 2.14e-01 | -0.0353 |
8793 | TNFRSF10D | Pat06-B | Human | Stomach | GC | 9.98e-06 | 1.07e-01 | -0.1961 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF10D | SNV | Missense_Mutation | c.179N>A | p.Arg60Gln | p.R60Q | Q9UBN6 | protein_coding | tolerated(0.31) | benign(0.021) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TNFRSF10D | SNV | Missense_Mutation | rs747563213 | c.494G>T | p.Gly165Val | p.G165V | Q9UBN6 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.488N>T | p.Pro163Leu | p.P163L | Q9UBN6 | protein_coding | deleterious(0) | possibly_damaging(0.661) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TNFRSF10D | SNV | Missense_Mutation | rs201641657 | c.386N>A | p.Ser129Asn | p.S129N | Q9UBN6 | protein_coding | tolerated(0.08) | benign(0.045) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TNFRSF10D | SNV | Missense_Mutation | c.945G>T | p.Gln315His | p.Q315H | Q9UBN6 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TNFRSF10D | SNV | Missense_Mutation | novel | c.430N>A | p.Gly144Arg | p.G144R | Q9UBN6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | rs574854967 | c.94C>T | p.Leu32Phe | p.L32F | Q9UBN6 | protein_coding | tolerated(0.14) | possibly_damaging(0.836) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.884N>C | p.Ile295Thr | p.I295T | Q9UBN6 | protein_coding | tolerated(0.13) | probably_damaging(0.992) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.161A>G | p.Asp54Gly | p.D54G | Q9UBN6 | protein_coding | tolerated(0.49) | benign(0.058) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | rs189314147 | c.68N>T | p.Arg23Met | p.R23M | Q9UBN6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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