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Gene: TMTC2 |
Gene summary for TMTC2 |
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Gene information | Species | Human | Gene symbol | TMTC2 | Gene ID | 160335 |
Gene name | transmembrane O-mannosyltransferase targeting cadherins 2 | |
Gene Alias | IBDBP1 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B7Z639 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
160335 | TMTC2 | CCI_1 | Human | Cervix | CC | 3.44e-20 | 1.20e+00 | 0.528 |
160335 | TMTC2 | CCI_2 | Human | Cervix | CC | 1.79e-10 | 1.51e+00 | 0.5249 |
160335 | TMTC2 | CCI_3 | Human | Cervix | CC | 1.15e-11 | 7.10e-01 | 0.516 |
160335 | TMTC2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.56e-12 | 8.38e-01 | -0.0811 |
160335 | TMTC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.36e-03 | 6.06e-01 | -0.059 |
160335 | TMTC2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.13e-17 | 1.66e+00 | 0.3487 |
160335 | TMTC2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.63e-14 | -5.69e-01 | 0.3005 |
160335 | TMTC2 | A002-C-010 | Human | Colorectum | FAP | 2.02e-06 | 3.02e-01 | 0.242 |
160335 | TMTC2 | A015-C-203 | Human | Colorectum | FAP | 2.02e-27 | -5.75e-01 | -0.1294 |
160335 | TMTC2 | A015-C-204 | Human | Colorectum | FAP | 4.22e-03 | -3.11e-01 | -0.0228 |
160335 | TMTC2 | A002-C-201 | Human | Colorectum | FAP | 2.96e-07 | -2.36e-01 | 0.0324 |
160335 | TMTC2 | A002-C-203 | Human | Colorectum | FAP | 4.07e-02 | 2.36e-01 | 0.2786 |
160335 | TMTC2 | A001-C-119 | Human | Colorectum | FAP | 2.08e-08 | -5.11e-01 | -0.1557 |
160335 | TMTC2 | A001-C-108 | Human | Colorectum | FAP | 1.10e-10 | -2.72e-01 | -0.0272 |
160335 | TMTC2 | A002-C-205 | Human | Colorectum | FAP | 2.72e-21 | -5.23e-01 | -0.1236 |
160335 | TMTC2 | A015-C-005 | Human | Colorectum | FAP | 1.49e-04 | -4.05e-01 | -0.0336 |
160335 | TMTC2 | A015-C-006 | Human | Colorectum | FAP | 2.87e-14 | -5.80e-01 | -0.0994 |
160335 | TMTC2 | A015-C-106 | Human | Colorectum | FAP | 2.14e-04 | -2.94e-01 | -0.0511 |
160335 | TMTC2 | A002-C-114 | Human | Colorectum | FAP | 9.26e-19 | -5.81e-01 | -0.1561 |
160335 | TMTC2 | A015-C-104 | Human | Colorectum | FAP | 4.13e-27 | -5.96e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00064861 | Colorectum | FAP | protein glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00434131 | Colorectum | FAP | macromolecule glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00700851 | Colorectum | FAP | glycosylation | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:0009101 | Colorectum | FAP | glycoprotein biosynthetic process | 63/2622 | 317/18723 | 2.31e-03 | 1.86e-02 | 63 |
GO:0006493 | Lung | AIS | protein O-linked glycosylation | 17/1849 | 86/18723 | 4.04e-03 | 3.65e-02 | 17 |
GO:00064863 | Lung | AIS | protein glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
GO:00434133 | Lung | AIS | macromolecule glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMTC2 | SNV | Missense_Mutation | rs767830943 | c.767N>T | p.Ser256Leu | p.S256L | Q8N394 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMTC2 | SNV | Missense_Mutation | c.980G>A | p.Gly327Asp | p.G327D | Q8N394 | protein_coding | tolerated(0.15) | benign(0.03) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMTC2 | SNV | Missense_Mutation | c.1246G>C | p.Gly416Arg | p.G416R | Q8N394 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TMTC2 | SNV | Missense_Mutation | rs763597437 | c.131C>T | p.Thr44Met | p.T44M | Q8N394 | protein_coding | tolerated(0.21) | benign(0.34) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMTC2 | SNV | Missense_Mutation | c.221N>A | p.Arg74His | p.R74H | Q8N394 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMTC2 | SNV | Missense_Mutation | rs746969722 | c.1568G>A | p.Arg523His | p.R523H | Q8N394 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMTC2 | SNV | Missense_Mutation | rs745749518 | c.86N>A | p.Arg29His | p.R29H | Q8N394 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMTC2 | SNV | Missense_Mutation | c.502N>C | p.Thr168Pro | p.T168P | Q8N394 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMTC2 | SNV | Missense_Mutation | novel | c.52N>C | p.Thr18Pro | p.T18P | Q8N394 | protein_coding | deleterious(0.01) | possibly_damaging(0.548) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TMTC2 | SNV | Missense_Mutation | c.967C>A | p.Leu323Ile | p.L323I | Q8N394 | protein_coding | tolerated(0.12) | probably_damaging(0.912) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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