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Gene: TMEM38A |
Gene summary for TMEM38A |
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Gene information | Species | Human | Gene symbol | TMEM38A | Gene ID | 79041 |
Gene name | transmembrane protein 38A | |
Gene Alias | TRIC-A | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9H6F2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79041 | TMEM38A | HCC1_Meng | Human | Liver | HCC | 2.87e-30 | 7.24e-02 | 0.0246 |
79041 | TMEM38A | HCC2_Meng | Human | Liver | HCC | 3.68e-06 | 7.11e-02 | 0.0107 |
79041 | TMEM38A | HCC1 | Human | Liver | HCC | 4.04e-09 | 1.11e+00 | 0.5336 |
79041 | TMEM38A | HCC2 | Human | Liver | HCC | 5.76e-22 | 2.44e+00 | 0.5341 |
79041 | TMEM38A | HCC5 | Human | Liver | HCC | 1.53e-08 | 1.09e+00 | 0.4932 |
79041 | TMEM38A | S028 | Human | Liver | HCC | 1.67e-09 | 3.94e-01 | 0.2503 |
79041 | TMEM38A | S029 | Human | Liver | HCC | 1.25e-06 | 3.57e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000702911 | Liver | HCC | endoplasmic reticulum organization | 64/7958 | 87/18723 | 3.92e-09 | 1.04e-07 | 64 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:001407421 | Liver | HCC | response to purine-containing compound | 84/7958 | 148/18723 | 3.19e-04 | 2.26e-03 | 84 |
GO:00432791 | Liver | HCC | response to alkaloid | 62/7958 | 115/18723 | 8.79e-03 | 3.42e-02 | 62 |
GO:0010882 | Liver | HCC | regulation of cardiac muscle contraction by calcium ion signaling | 18/7958 | 27/18723 | 9.75e-03 | 3.66e-02 | 18 |
GO:0010881 | Liver | HCC | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 15/7958 | 22/18723 | 1.35e-02 | 4.80e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM38A | SNV | Missense_Mutation | novel | c.294N>A | p.Phe98Leu | p.F98L | Q9H6F2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM38A | SNV | Missense_Mutation | novel | c.891G>T | p.Lys297Asn | p.K297N | Q9H6F2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
TMEM38A | SNV | Missense_Mutation | rs765687661 | c.133N>A | p.Glu45Lys | p.E45K | Q9H6F2 | protein_coding | tolerated(0.19) | possibly_damaging(0.838) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM38A | SNV | Missense_Mutation | novel | c.143N>T | p.Arg48Leu | p.R48L | Q9H6F2 | protein_coding | tolerated(0.64) | possibly_damaging(0.665) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TMEM38A | SNV | Missense_Mutation | c.409G>A | p.Ala137Thr | p.A137T | Q9H6F2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TMEM38A | SNV | Missense_Mutation | novel | c.369G>T | p.Glu123Asp | p.E123D | Q9H6F2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM38A | SNV | Missense_Mutation | c.758N>A | p.Cys253Tyr | p.C253Y | Q9H6F2 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM38A | SNV | Missense_Mutation | c.701G>A | p.Ser234Asn | p.S234N | Q9H6F2 | protein_coding | tolerated(0.18) | benign(0.037) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM38A | SNV | Missense_Mutation | novel | c.440N>A | p.Val147Asp | p.V147D | Q9H6F2 | protein_coding | deleterious(0) | possibly_damaging(0.478) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
TMEM38A | SNV | Missense_Mutation | c.409G>A | p.Ala137Thr | p.A137T | Q9H6F2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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