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Gene: TMEM181 |
Gene summary for TMEM181 |
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Gene information | Species | Human | Gene symbol | TMEM181 | Gene ID | 57583 |
Gene name | transmembrane protein 181 | |
Gene Alias | GPR178 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9P2C4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57583 | TMEM181 | LZE7T | Human | Esophagus | ESCC | 2.34e-12 | 2.06e-01 | 0.0667 |
57583 | TMEM181 | LZE8T | Human | Esophagus | ESCC | 4.84e-05 | 5.50e-02 | 0.067 |
57583 | TMEM181 | LZE24T | Human | Esophagus | ESCC | 2.12e-07 | 7.96e-02 | 0.0596 |
57583 | TMEM181 | LZE21T | Human | Esophagus | ESCC | 4.35e-03 | 7.01e-02 | 0.0655 |
57583 | TMEM181 | P1T-E | Human | Esophagus | ESCC | 1.84e-05 | 2.01e-01 | 0.0875 |
57583 | TMEM181 | P2T-E | Human | Esophagus | ESCC | 3.48e-14 | 1.89e-01 | 0.1177 |
57583 | TMEM181 | P4T-E | Human | Esophagus | ESCC | 3.95e-11 | 1.92e-01 | 0.1323 |
57583 | TMEM181 | P5T-E | Human | Esophagus | ESCC | 7.67e-14 | 2.45e-02 | 0.1327 |
57583 | TMEM181 | P8T-E | Human | Esophagus | ESCC | 3.11e-18 | 2.65e-01 | 0.0889 |
57583 | TMEM181 | P9T-E | Human | Esophagus | ESCC | 6.28e-17 | 7.68e-02 | 0.1131 |
57583 | TMEM181 | P10T-E | Human | Esophagus | ESCC | 4.22e-16 | 3.47e-01 | 0.116 |
57583 | TMEM181 | P11T-E | Human | Esophagus | ESCC | 4.27e-08 | 1.96e-01 | 0.1426 |
57583 | TMEM181 | P12T-E | Human | Esophagus | ESCC | 2.02e-12 | 1.63e-01 | 0.1122 |
57583 | TMEM181 | P15T-E | Human | Esophagus | ESCC | 2.66e-12 | 2.34e-01 | 0.1149 |
57583 | TMEM181 | P16T-E | Human | Esophagus | ESCC | 5.28e-64 | 1.52e+00 | 0.1153 |
57583 | TMEM181 | P17T-E | Human | Esophagus | ESCC | 7.11e-03 | 2.61e-01 | 0.1278 |
57583 | TMEM181 | P20T-E | Human | Esophagus | ESCC | 3.29e-13 | 8.41e-02 | 0.1124 |
57583 | TMEM181 | P21T-E | Human | Esophagus | ESCC | 1.82e-25 | 4.08e-01 | 0.1617 |
57583 | TMEM181 | P22T-E | Human | Esophagus | ESCC | 3.43e-17 | 1.18e-01 | 0.1236 |
57583 | TMEM181 | P23T-E | Human | Esophagus | ESCC | 2.75e-11 | 1.58e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM181 | SNV | Missense_Mutation | c.1614C>A | p.Phe538Leu | p.F538L | Q9P2C4 | protein_coding | deleterious(0.02) | probably_damaging(0.947) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMEM181 | SNV | Missense_Mutation | novel | c.1607C>A | p.Ala536Asp | p.A536D | Q9P2C4 | protein_coding | deleterious(0.01) | benign(0.428) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM181 | SNV | Missense_Mutation | c.964N>A | p.Val322Met | p.V322M | Q9P2C4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
TMEM181 | SNV | Missense_Mutation | rs375809123 | c.1550N>T | p.Ala517Val | p.A517V | Q9P2C4 | protein_coding | tolerated(0.22) | benign(0.265) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM181 | SNV | Missense_Mutation | c.1645C>A | p.Leu549Ile | p.L549I | Q9P2C4 | protein_coding | tolerated(0.19) | possibly_damaging(0.518) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
TMEM181 | SNV | Missense_Mutation | rs375809123 | c.1550N>T | p.Ala517Val | p.A517V | Q9P2C4 | protein_coding | tolerated(0.22) | benign(0.265) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TMEM181 | SNV | Missense_Mutation | novel | c.1315G>A | p.Glu439Lys | p.E439K | Q9P2C4 | protein_coding | deleterious(0.04) | probably_damaging(0.955) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM181 | insertion | Frame_Shift_Ins | novel | c.519_520insA | p.Arg174LysfsTer4 | p.R174Kfs*4 | Q9P2C4 | protein_coding | TCGA-AF-6672-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Ancillary | leucovorin | PD | ||
TMEM181 | SNV | Missense_Mutation | novel | c.1726N>G | p.Met576Val | p.M576V | Q9P2C4 | protein_coding | deleterious(0) | benign(0.297) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM181 | SNV | Missense_Mutation | c.457C>T | p.His153Tyr | p.H153Y | Q9P2C4 | protein_coding | tolerated(0.09) | benign(0.093) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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