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Gene: TMEM171 |
Gene summary for TMEM171 |
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Gene information | Species | Human | Gene symbol | TMEM171 | Gene ID | 134285 |
Gene name | transmembrane protein 171 | |
Gene Alias | PRP2 | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WVE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134285 | TMEM171 | P1T-E | Human | Esophagus | ESCC | 2.44e-06 | 2.74e-01 | 0.0875 |
134285 | TMEM171 | P4T-E | Human | Esophagus | ESCC | 1.36e-04 | 1.39e-01 | 0.1323 |
134285 | TMEM171 | P5T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.29e-01 | 0.1327 |
134285 | TMEM171 | P8T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.40e-01 | 0.0889 |
134285 | TMEM171 | P9T-E | Human | Esophagus | ESCC | 5.74e-10 | 2.55e-01 | 0.1131 |
134285 | TMEM171 | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.99e-01 | 0.116 |
134285 | TMEM171 | P12T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.71e-01 | 0.1122 |
134285 | TMEM171 | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 1.04e-01 | 0.1124 |
134285 | TMEM171 | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.10e-01 | 0.1617 |
134285 | TMEM171 | P23T-E | Human | Esophagus | ESCC | 1.18e-21 | 4.87e-01 | 0.108 |
134285 | TMEM171 | P26T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.95e-01 | 0.1276 |
134285 | TMEM171 | P27T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.33e-02 | 0.1055 |
134285 | TMEM171 | P28T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.67e-01 | 0.1149 |
134285 | TMEM171 | P32T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.15e-01 | 0.1666 |
134285 | TMEM171 | P37T-E | Human | Esophagus | ESCC | 9.96e-06 | 1.40e-01 | 0.1371 |
134285 | TMEM171 | P40T-E | Human | Esophagus | ESCC | 5.68e-07 | 2.09e-01 | 0.109 |
134285 | TMEM171 | P42T-E | Human | Esophagus | ESCC | 2.62e-05 | 2.30e-01 | 0.1175 |
134285 | TMEM171 | P47T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.84e-02 | 0.1067 |
134285 | TMEM171 | P49T-E | Human | Esophagus | ESCC | 7.48e-03 | 3.72e-01 | 0.1768 |
134285 | TMEM171 | P52T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.68e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM171 | SNV | Missense_Mutation | c.185N>T | p.Ala62Val | p.A62V | Q8WVE6 | protein_coding | tolerated(0.2) | benign(0.014) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
TMEM171 | SNV | Missense_Mutation | c.194N>T | p.Ala65Val | p.A65V | Q8WVE6 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
TMEM171 | SNV | Missense_Mutation | c.841N>C | p.Ile281Leu | p.I281L | Q8WVE6 | protein_coding | deleterious(0) | benign(0.392) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM171 | SNV | Missense_Mutation | novel | c.867G>T | p.Glu289Asp | p.E289D | Q8WVE6 | protein_coding | tolerated(0.35) | benign(0.057) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TMEM171 | SNV | Missense_Mutation | novel | c.451G>A | p.Gly151Ser | p.G151S | Q8WVE6 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM171 | SNV | Missense_Mutation | c.476G>T | p.Gly159Val | p.G159V | Q8WVE6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-BG-A0VT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
TMEM171 | SNV | Missense_Mutation | rs137882806 | c.296G>A | p.Arg99Gln | p.R99Q | Q8WVE6 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BS-A0UL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM171 | SNV | Missense_Mutation | c.701N>A | p.Ser234Tyr | p.S234Y | Q8WVE6 | protein_coding | deleterious(0.03) | possibly_damaging(0.875) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM171 | SNV | Missense_Mutation | novel | c.230N>T | p.Ala77Val | p.A77V | Q8WVE6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM171 | SNV | Missense_Mutation | novel | c.218N>G | p.Ala73Gly | p.A73G | Q8WVE6 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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