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Gene: TMEM132D |
Gene summary for TMEM132D |
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Gene information | Species | Human | Gene symbol | TMEM132D | Gene ID | 121256 |
Gene name | transmembrane protein 132D | |
Gene Alias | MOLT | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q14C87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121256 | TMEM132D | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 4.84e-05 | 1.34e+00 | -0.0272 |
121256 | TMEM132D | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 4.72e-06 | 1.42e+00 | 0.0057 |
121256 | TMEM132D | RNA-P5T2-P5T2-1 | Human | Lung | MIAC | 2.56e-04 | 1.44e+00 | -0.0135 |
121256 | TMEM132D | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 6.72e-03 | 9.50e-01 | -0.0238 |
121256 | TMEM132D | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.36e-02 | 8.16e-01 | -0.0263 |
121256 | TMEM132D | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.69e-05 | 7.75e-01 | -0.0961 |
121256 | TMEM132D | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 5.59e-06 | 7.83e-01 | -0.0876 |
121256 | TMEM132D | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.32e-05 | 7.21e-01 | -0.0822 |
121256 | TMEM132D | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.09e-06 | 7.42e-01 | -0.0809 |
121256 | TMEM132D | HTA12-15-2 | Human | Pancreas | PDAC | 1.28e-15 | 1.01e+00 | 0.2315 |
121256 | TMEM132D | HTA12-16-2 | Human | Pancreas | PDAC | 1.71e-02 | 7.57e-01 | 0.0535 |
121256 | TMEM132D | HTA12-23-1 | Human | Pancreas | PDAC | 7.33e-25 | 1.57e+00 | 0.3405 |
121256 | TMEM132D | HTA12-25-1 | Human | Pancreas | PDAC | 9.43e-22 | 1.40e+00 | 0.313 |
121256 | TMEM132D | HTA12-26-1 | Human | Pancreas | PDAC | 2.17e-46 | 1.74e+00 | 0.3728 |
121256 | TMEM132D | HTA12-29-1 | Human | Pancreas | PDAC | 5.10e-104 | 1.69e+00 | 0.3722 |
121256 | TMEM132D | HTA12-30-1 | Human | Pancreas | PDAC | 6.56e-10 | 1.55e+00 | 0.3671 |
121256 | TMEM132D | HTA12-32-1 | Human | Pancreas | PDAC | 1.44e-13 | 1.70e+00 | 0.3624 |
121256 | TMEM132D | HTA12-9-1 | Human | Pancreas | PDAC | 3.82e-02 | 2.81e-01 | 0.1532 |
121256 | TMEM132D | HTA12-9-2 | Human | Pancreas | PDAC | 1.65e-02 | 2.37e-01 | 0.0835 |
121256 | TMEM132D | HTA12-9-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.51e-01 | 0.2045 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM132D | SNV | Missense_Mutation | rs376007280 | c.1553N>T | p.Thr518Met | p.T518M | Q14C87 | protein_coding | deleterious(0.01) | benign(0.154) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TMEM132D | SNV | Missense_Mutation | c.1756G>A | p.Glu586Lys | p.E586K | Q14C87 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM132D | SNV | Missense_Mutation | c.2253C>A | p.Phe751Leu | p.F751L | Q14C87 | protein_coding | tolerated(0.66) | benign(0.006) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM132D | SNV | Missense_Mutation | rs764438255 | c.631N>A | p.Gly211Arg | p.G211R | Q14C87 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM132D | SNV | Missense_Mutation | c.2379N>G | p.Ile793Met | p.I793M | Q14C87 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
TMEM132D | SNV | Missense_Mutation | rs750957356 | c.620N>T | p.Thr207Met | p.T207M | Q14C87 | protein_coding | tolerated(0.05) | benign(0.11) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TMEM132D | SNV | Missense_Mutation | c.2892G>T | p.Trp964Cys | p.W964C | Q14C87 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
TMEM132D | insertion | Frame_Shift_Ins | novel | c.2407_2408insGGGCGAAGTTGTTCTCTAAAAAAGAGAATAGCAG | p.Asn803ArgfsTer17 | p.N803Rfs*17 | Q14C87 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TMEM132D | insertion | Frame_Shift_Ins | novel | c.2301_2302insCACC | p.Lys768HisfsTer8 | p.K768Hfs*8 | Q14C87 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM132D | insertion | In_Frame_Ins | novel | c.2299_2300insCTGGAGTGACCTTACAGGGGCAGCCACAAGACC | p.Val767delinsAlaGlyValThrLeuGlnGlyGlnProGlnAspLeu | p.V767delinsAGVTLQGQPQDL | Q14C87 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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