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Gene: TMCO6 |
Gene summary for TMCO6 |
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Gene information | Species | Human | Gene symbol | TMCO6 | Gene ID | 55374 |
Gene name | transmembrane and coiled-coil domains 6 | |
Gene Alias | PRO1580 | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006606 | UniProtAcc | Q96DC7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55374 | TMCO6 | LZE24T | Human | Esophagus | ESCC | 6.85e-08 | 2.26e-01 | 0.0596 |
55374 | TMCO6 | P2T-E | Human | Esophagus | ESCC | 6.54e-16 | 1.37e-01 | 0.1177 |
55374 | TMCO6 | P4T-E | Human | Esophagus | ESCC | 5.78e-04 | 1.83e-01 | 0.1323 |
55374 | TMCO6 | P5T-E | Human | Esophagus | ESCC | 2.50e-07 | 1.03e-01 | 0.1327 |
55374 | TMCO6 | P8T-E | Human | Esophagus | ESCC | 5.57e-05 | 1.11e-01 | 0.0889 |
55374 | TMCO6 | P10T-E | Human | Esophagus | ESCC | 8.63e-06 | 8.43e-02 | 0.116 |
55374 | TMCO6 | P12T-E | Human | Esophagus | ESCC | 1.84e-18 | 3.61e-01 | 0.1122 |
55374 | TMCO6 | P15T-E | Human | Esophagus | ESCC | 3.25e-11 | 2.66e-01 | 0.1149 |
55374 | TMCO6 | P16T-E | Human | Esophagus | ESCC | 4.79e-11 | 1.55e-01 | 0.1153 |
55374 | TMCO6 | P20T-E | Human | Esophagus | ESCC | 6.13e-17 | 4.03e-01 | 0.1124 |
55374 | TMCO6 | P21T-E | Human | Esophagus | ESCC | 3.48e-13 | 1.77e-01 | 0.1617 |
55374 | TMCO6 | P22T-E | Human | Esophagus | ESCC | 5.27e-13 | 1.84e-01 | 0.1236 |
55374 | TMCO6 | P23T-E | Human | Esophagus | ESCC | 2.87e-06 | 1.79e-01 | 0.108 |
55374 | TMCO6 | P24T-E | Human | Esophagus | ESCC | 2.24e-17 | 1.52e-01 | 0.1287 |
55374 | TMCO6 | P26T-E | Human | Esophagus | ESCC | 8.92e-11 | 1.91e-01 | 0.1276 |
55374 | TMCO6 | P27T-E | Human | Esophagus | ESCC | 1.55e-07 | 1.20e-01 | 0.1055 |
55374 | TMCO6 | P28T-E | Human | Esophagus | ESCC | 4.19e-07 | 1.38e-01 | 0.1149 |
55374 | TMCO6 | P30T-E | Human | Esophagus | ESCC | 2.43e-05 | 2.29e-01 | 0.137 |
55374 | TMCO6 | P31T-E | Human | Esophagus | ESCC | 6.81e-07 | 1.45e-01 | 0.1251 |
55374 | TMCO6 | P32T-E | Human | Esophagus | ESCC | 1.62e-08 | 1.14e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMCO6 | SNV | Missense_Mutation | c.1148N>G | p.Ser383Cys | p.S383C | Q96DC7 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
TMCO6 | SNV | Missense_Mutation | c.1045T>C | p.Phe349Leu | p.F349L | Q96DC7 | protein_coding | tolerated(0.11) | possibly_damaging(0.638) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TMCO6 | SNV | Missense_Mutation | c.805C>T | p.Leu269Phe | p.L269F | Q96DC7 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMCO6 | SNV | Missense_Mutation | rs758163180 | c.272N>A | p.Arg91His | p.R91H | Q96DC7 | protein_coding | tolerated(0.05) | probably_damaging(0.997) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMCO6 | SNV | Missense_Mutation | rs749485111 | c.949N>A | p.Val317Met | p.V317M | Q96DC7 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TMCO6 | SNV | Missense_Mutation | rs375233479 | c.956G>A | p.Arg319Gln | p.R319Q | Q96DC7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMCO6 | SNV | Missense_Mutation | novel | c.257C>A | p.Ala86Asp | p.A86D | Q96DC7 | protein_coding | tolerated(0.23) | probably_damaging(0.998) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCO6 | SNV | Missense_Mutation | rs777697901 | c.383C>T | p.Ala128Val | p.A128V | Q96DC7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCO6 | SNV | Missense_Mutation | rs777697901 | c.383C>T | p.Ala128Val | p.A128V | Q96DC7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMCO6 | SNV | Missense_Mutation | c.584N>T | p.Ala195Val | p.A195V | Q96DC7 | protein_coding | tolerated(0.42) | benign(0.017) | TCGA-G4-6307-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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