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Gene: TMCC3 |
Gene summary for TMCC3 |
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Gene information | Species | Human | Gene symbol | TMCC3 | Gene ID | 57458 |
Gene name | transmembrane and coiled-coil domain family 3 | |
Gene Alias | TMCC3 | |
Cytomap | 12q22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | G3V207 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57458 | TMCC3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.71e-03 | 3.90e-01 | -0.1706 |
57458 | TMCC3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.59e-07 | -2.48e-01 | 0.3005 |
57458 | TMCC3 | A015-C-203 | Human | Colorectum | FAP | 3.80e-02 | -8.68e-02 | -0.1294 |
57458 | TMCC3 | A002-C-201 | Human | Colorectum | FAP | 5.81e-04 | -2.17e-01 | 0.0324 |
57458 | TMCC3 | A002-C-203 | Human | Colorectum | FAP | 5.34e-04 | -1.76e-01 | 0.2786 |
57458 | TMCC3 | A002-C-205 | Human | Colorectum | FAP | 6.24e-04 | -2.14e-01 | -0.1236 |
57458 | TMCC3 | A015-C-106 | Human | Colorectum | FAP | 4.18e-04 | -2.31e-01 | -0.0511 |
57458 | TMCC3 | A002-C-114 | Human | Colorectum | FAP | 1.34e-02 | -2.02e-01 | -0.1561 |
57458 | TMCC3 | A015-C-104 | Human | Colorectum | FAP | 1.26e-05 | -2.08e-01 | -0.1899 |
57458 | TMCC3 | A001-C-014 | Human | Colorectum | FAP | 2.23e-02 | -1.71e-01 | 0.0135 |
57458 | TMCC3 | A002-C-116 | Human | Colorectum | FAP | 5.20e-04 | -1.90e-01 | -0.0452 |
57458 | TMCC3 | A018-E-020 | Human | Colorectum | FAP | 7.66e-03 | -1.88e-01 | -0.2034 |
57458 | TMCC3 | F034 | Human | Colorectum | FAP | 5.17e-04 | -2.00e-01 | -0.0665 |
57458 | TMCC3 | CRC-1-8810 | Human | Colorectum | CRC | 3.45e-03 | -2.25e-01 | 0.6257 |
57458 | TMCC3 | LZE7T | Human | Esophagus | ESCC | 1.79e-03 | 1.81e-01 | 0.0667 |
57458 | TMCC3 | LZE24T | Human | Esophagus | ESCC | 1.00e-07 | 8.93e-02 | 0.0596 |
57458 | TMCC3 | P4T-E | Human | Esophagus | ESCC | 4.46e-04 | 1.01e-01 | 0.1323 |
57458 | TMCC3 | P5T-E | Human | Esophagus | ESCC | 5.32e-04 | 4.59e-03 | 0.1327 |
57458 | TMCC3 | P12T-E | Human | Esophagus | ESCC | 2.30e-09 | 7.71e-02 | 0.1122 |
57458 | TMCC3 | P20T-E | Human | Esophagus | ESCC | 2.26e-03 | 5.59e-03 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMCC3 | SNV | Missense_Mutation | novel | c.782N>T | p.Thr261Met | p.T261M | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TMCC3 | SNV | Missense_Mutation | c.569N>T | p.Gly190Val | p.G190V | Q9ULS5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMCC3 | SNV | Missense_Mutation | c.1103N>C | p.Gln368Pro | p.Q368P | Q9ULS5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
TMCC3 | SNV | Missense_Mutation | rs370011735 | c.557N>T | p.Ser186Leu | p.S186L | Q9ULS5 | protein_coding | deleterious(0.02) | benign(0.2) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMCC3 | SNV | Missense_Mutation | rs762276134 | c.494G>A | p.Arg165His | p.R165H | Q9ULS5 | protein_coding | tolerated(0.1) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | c.435G>C | p.Gln145His | p.Q145H | Q9ULS5 | protein_coding | tolerated(0.29) | probably_damaging(0.991) | TCGA-AZ-6605-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfox | SD | |
TMCC3 | SNV | Missense_Mutation | c.449N>T | p.Arg150Met | p.R150M | Q9ULS5 | protein_coding | deleterious(0.03) | probably_damaging(0.954) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMCC3 | SNV | Missense_Mutation | rs779756372 | c.1118N>T | p.Ser373Leu | p.S373L | Q9ULS5 | protein_coding | tolerated(0.17) | benign(0.207) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | rs776843349 | c.968N>A | p.Ser323Tyr | p.S323Y | Q9ULS5 | protein_coding | tolerated(0.07) | probably_damaging(0.971) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | novel | c.91N>T | p.Asp31Tyr | p.D31Y | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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