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Gene: TLR10 |
Gene summary for TLR10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TLR10 | Gene ID | 81793 |
| Gene name | toll like receptor 10 | |
| Gene Alias | CD290 | |
| Cytomap | 4p14 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A0A024R9W4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 81793 | TLR10 | HCC1 | Human | Liver | HCC | 2.54e-07 | 7.48e-01 | 0.5336 |
| 81793 | TLR10 | HCC2 | Human | Liver | HCC | 2.17e-19 | 1.37e+00 | 0.5341 |
| 81793 | TLR10 | HCC5 | Human | Liver | HCC | 6.74e-23 | 1.22e+00 | 0.4932 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00022211 | Liver | HCC | pattern recognition receptor signaling pathway | 107/7958 | 172/18723 | 1.37e-07 | 2.58e-06 | 107 |
| GO:0002224 | Liver | HCC | toll-like receptor signaling pathway | 67/7958 | 121/18723 | 2.87e-03 | 1.34e-02 | 67 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TLR10 | SNV | Missense_Mutation | c.1063T>G | p.Phe355Val | p.F355V | Q9BXR5 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
| TLR10 | SNV | Missense_Mutation | c.1409N>G | p.Glu470Gly | p.E470G | Q9BXR5 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | c.1810N>T | p.Pro604Ser | p.P604S | Q9BXR5 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | c.1316G>T | p.Arg439Met | p.R439M | Q9BXR5 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | c.1379N>C | p.Lys460Thr | p.K460T | Q9BXR5 | protein_coding | deleterious(0.03) | possibly_damaging(0.677) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | c.2276A>C | p.Lys759Thr | p.K759T | Q9BXR5 | protein_coding | tolerated(0.14) | benign(0.132) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | c.829C>G | p.Arg277Gly | p.R277G | Q9BXR5 | protein_coding | tolerated(0.32) | benign(0.049) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
| TLR10 | SNV | Missense_Mutation | rs375480992 | c.152N>T | p.Thr51Met | p.T51M | Q9BXR5 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TLR10 | SNV | Missense_Mutation | c.2205N>A | p.Phe735Leu | p.F735L | Q9BXR5 | protein_coding | tolerated(0.64) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TLR10 | SNV | Missense_Mutation | novel | c.265N>T | p.Leu89Phe | p.L89F | Q9BXR5 | protein_coding | tolerated(0.69) | benign(0.014) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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