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Gene: TLK1 |
Gene summary for TLK1 |
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Gene information | Species | Human | Gene symbol | TLK1 | Gene ID | 9874 |
Gene name | tousled like kinase 1 | |
Gene Alias | PKU-beta | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001672 | UniProtAcc | Q9UKI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9874 | TLK1 | CA_HPV_1 | Human | Cervix | CC | 4.78e-08 | 1.47e-02 | 0.0264 |
9874 | TLK1 | CCI_2 | Human | Cervix | CC | 5.72e-05 | 7.72e-01 | 0.5249 |
9874 | TLK1 | CCI_3 | Human | Cervix | CC | 1.14e-03 | 7.14e-01 | 0.516 |
9874 | TLK1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.77e-23 | -6.62e-01 | 0.0155 |
9874 | TLK1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.94e-03 | -7.39e-01 | 0.0216 |
9874 | TLK1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.50e-02 | 3.56e-01 | -0.2602 |
9874 | TLK1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.11e-05 | -5.73e-01 | -0.1207 |
9874 | TLK1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.13e-03 | -3.29e-01 | -0.1464 |
9874 | TLK1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.14e-04 | -6.65e-01 | -0.2061 |
9874 | TLK1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.25e-02 | -6.07e-01 | -0.1462 |
9874 | TLK1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.57e-16 | -6.42e-01 | 0.096 |
9874 | TLK1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 5.36e-03 | -8.13e-01 | 0.0451 |
9874 | TLK1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.21e-07 | -8.01e-01 | 0.0528 |
9874 | TLK1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.50e-11 | -6.35e-01 | 0.0338 |
9874 | TLK1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.15e-15 | -5.44e-01 | 0.0674 |
9874 | TLK1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.71e-04 | -6.22e-01 | 0.0112 |
9874 | TLK1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.06e-04 | -4.12e-01 | 0.294 |
9874 | TLK1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.15e-13 | -6.01e-01 | 0.3859 |
9874 | TLK1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.94e-12 | -7.39e-01 | 0.2585 |
9874 | TLK1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.49e-21 | -6.79e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
GO:00182096 | Cervix | CC | peptidyl-serine modification | 66/2311 | 338/18723 | 9.58e-05 | 1.25e-03 | 66 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00181051 | Colorectum | SER | peptidyl-serine phosphorylation | 66/2897 | 315/18723 | 5.47e-03 | 4.06e-02 | 66 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00181052 | Colorectum | MSS | peptidyl-serine phosphorylation | 81/3467 | 315/18723 | 8.92e-04 | 9.12e-03 | 81 |
GO:00182091 | Colorectum | MSS | peptidyl-serine modification | 84/3467 | 338/18723 | 2.12e-03 | 1.79e-02 | 84 |
GO:00181053 | Colorectum | FAP | peptidyl-serine phosphorylation | 71/2622 | 315/18723 | 2.51e-05 | 5.82e-04 | 71 |
GO:00182092 | Colorectum | FAP | peptidyl-serine modification | 73/2622 | 338/18723 | 8.47e-05 | 1.51e-03 | 73 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00181054 | Colorectum | CRC | peptidyl-serine phosphorylation | 61/2078 | 315/18723 | 9.88e-06 | 3.31e-04 | 61 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00182093 | Colorectum | CRC | peptidyl-serine modification | 62/2078 | 338/18723 | 4.67e-05 | 1.10e-03 | 62 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLK1 | SNV | Missense_Mutation | novel | c.98N>G | p.Ser33Cys | p.S33C | Q9UKI8 | protein_coding | tolerated_low_confidence(0.08) | benign(0.237) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TLK1 | SNV | Missense_Mutation | c.1393N>T | p.Gly465Cys | p.G465C | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.1046N>A | p.Arg349His | p.R349H | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.2165G>A | p.Arg722Gln | p.R722Q | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.1581C>A | p.Phe527Leu | p.F527L | Q9UKI8 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.1046G>A | p.Arg349His | p.R349H | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TLK1 | SNV | Missense_Mutation | c.1544T>A | p.Leu515Gln | p.L515Q | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TLK1 | SNV | Missense_Mutation | novel | c.88G>A | p.Ala30Thr | p.A30T | Q9UKI8 | protein_coding | tolerated_low_confidence(0.6) | benign(0.137) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLK1 | SNV | Missense_Mutation | c.683N>C | p.Lys228Thr | p.K228T | Q9UKI8 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TLK1 | SNV | Missense_Mutation | novel | c.557N>T | p.Pro186Leu | p.P186L | Q9UKI8 | protein_coding | tolerated(0.41) | benign(0) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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