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Gene: TKTL1 |
Gene summary for TKTL1 |
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Gene information | Species | Human | Gene symbol | TKTL1 | Gene ID | 8277 |
Gene name | transketolase like 1 | |
Gene Alias | TKR | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | B7Z7I0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8277 | TKTL1 | Tumor | Human | Cervix | CC | 4.67e-35 | 5.83e-01 | 0.1241 |
8277 | TKTL1 | sample3 | Human | Cervix | CC | 1.14e-39 | 5.62e-01 | 0.1387 |
8277 | TKTL1 | T3 | Human | Cervix | CC | 1.49e-37 | 4.99e-01 | 0.1389 |
8277 | TKTL1 | HCC2 | Human | Liver | HCC | 6.78e-79 | 6.86e+00 | 0.5341 |
8277 | TKTL1 | S014 | Human | Liver | HCC | 1.47e-02 | 6.25e-01 | 0.2254 |
8277 | TKTL1 | ATC13 | Human | Thyroid | ATC | 1.39e-92 | 2.49e+00 | 0.34 |
8277 | TKTL1 | ATC5 | Human | Thyroid | ATC | 1.23e-94 | 2.62e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
GO:000600621 | Liver | HCC | glucose metabolic process | 128/7958 | 196/18723 | 8.60e-11 | 3.06e-09 | 128 |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:001605222 | Liver | HCC | carbohydrate catabolic process | 99/7958 | 154/18723 | 3.79e-08 | 8.30e-07 | 99 |
GO:0006767 | Liver | HCC | water-soluble vitamin metabolic process | 39/7958 | 59/18723 | 2.14e-04 | 1.63e-03 | 39 |
GO:00725271 | Liver | HCC | pyrimidine-containing compound metabolic process | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:0006766 | Liver | HCC | vitamin metabolic process | 57/7958 | 106/18723 | 1.25e-02 | 4.53e-02 | 57 |
GO:003430812 | Liver | HCC | primary alcohol metabolic process | 55/7958 | 102/18723 | 1.30e-02 | 4.67e-02 | 55 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:000600616 | Thyroid | ATC | glucose metabolic process | 93/6293 | 196/18723 | 3.85e-05 | 3.14e-04 | 93 |
GO:001605224 | Thyroid | ATC | carbohydrate catabolic process | 71/6293 | 154/18723 | 8.33e-04 | 4.57e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0123021 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
hsa0123031 | Liver | HCC | Biosynthesis of amino acids | 53/4020 | 75/8465 | 3.79e-05 | 2.11e-04 | 1.18e-04 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TKTL1 | SNV | Missense_Mutation | c.1160N>C | p.Ile387Thr | p.I387T | P51854 | protein_coding | tolerated(0.06) | benign(0.309) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TKTL1 | deletion | Frame_Shift_Del | c.1174delN | p.Val393TyrfsTer16 | p.V393Yfs*16 | P51854 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
TKTL1 | SNV | Missense_Mutation | novel | c.256C>A | p.Leu86Met | p.L86M | P51854 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TKTL1 | SNV | Missense_Mutation | rs781802203 | c.1586N>A | p.Arg529Gln | p.R529Q | P51854 | protein_coding | tolerated(0.11) | benign(0.086) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TKTL1 | SNV | Missense_Mutation | rs781826654 | c.89N>A | p.Arg30His | p.R30H | P51854 | protein_coding | deleterious(0.05) | probably_damaging(0.984) | TCGA-AJ-A3EJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TKTL1 | SNV | Missense_Mutation | c.95N>A | p.Arg32Gln | p.R32Q | P51854 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TKTL1 | SNV | Missense_Mutation | c.1042N>A | p.Leu348Met | p.L348M | P51854 | protein_coding | deleterious(0.04) | benign(0.34) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TKTL1 | SNV | Missense_Mutation | novel | c.1352N>A | p.Thr451Asn | p.T451N | P51854 | protein_coding | tolerated(0.09) | benign(0.044) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TKTL1 | SNV | Missense_Mutation | novel | c.1664N>G | p.Asp555Gly | p.D555G | P51854 | protein_coding | tolerated(0.86) | benign(0.013) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TKTL1 | SNV | Missense_Mutation | novel | c.683N>T | p.Ala228Val | p.A228V | P51854 | protein_coding | tolerated(0.2) | benign(0.213) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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