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Gene: TIMM23 |
Gene summary for TIMM23 |
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Gene information | Species | Human | Gene symbol | TIMM23 | Gene ID | 100287932 |
Gene name | translocase of inner mitochondrial membrane 23 | |
Gene Alias | TIM23 | |
Cytomap | 10q11.22 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | O14925 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100287932 | TIMM23 | LZE2T | Human | Esophagus | ESCC | 3.43e-04 | 6.98e-01 | 0.082 |
100287932 | TIMM23 | LZE4T | Human | Esophagus | ESCC | 9.41e-11 | 2.28e-01 | 0.0811 |
100287932 | TIMM23 | LZE5T | Human | Esophagus | ESCC | 3.81e-04 | 3.67e-01 | 0.0514 |
100287932 | TIMM23 | LZE7T | Human | Esophagus | ESCC | 3.67e-07 | 3.40e-01 | 0.0667 |
100287932 | TIMM23 | LZE8T | Human | Esophagus | ESCC | 3.45e-08 | 4.07e-01 | 0.067 |
100287932 | TIMM23 | LZE20T | Human | Esophagus | ESCC | 3.89e-06 | 1.76e-01 | 0.0662 |
100287932 | TIMM23 | LZE24T | Human | Esophagus | ESCC | 8.33e-25 | 8.17e-01 | 0.0596 |
100287932 | TIMM23 | LZE21T | Human | Esophagus | ESCC | 2.92e-03 | 3.71e-01 | 0.0655 |
100287932 | TIMM23 | LZE6T | Human | Esophagus | ESCC | 1.42e-07 | 3.08e-01 | 0.0845 |
100287932 | TIMM23 | P1T-E | Human | Esophagus | ESCC | 4.04e-04 | 4.61e-01 | 0.0875 |
100287932 | TIMM23 | P2T-E | Human | Esophagus | ESCC | 4.64e-23 | 5.24e-01 | 0.1177 |
100287932 | TIMM23 | P4T-E | Human | Esophagus | ESCC | 2.23e-34 | 1.10e+00 | 0.1323 |
100287932 | TIMM23 | P5T-E | Human | Esophagus | ESCC | 2.27e-40 | 8.10e-01 | 0.1327 |
100287932 | TIMM23 | P8T-E | Human | Esophagus | ESCC | 1.00e-24 | 5.97e-01 | 0.0889 |
100287932 | TIMM23 | P9T-E | Human | Esophagus | ESCC | 1.10e-22 | 3.00e-01 | 0.1131 |
100287932 | TIMM23 | P10T-E | Human | Esophagus | ESCC | 5.14e-23 | 4.45e-01 | 0.116 |
100287932 | TIMM23 | P11T-E | Human | Esophagus | ESCC | 3.94e-15 | 8.64e-01 | 0.1426 |
100287932 | TIMM23 | P12T-E | Human | Esophagus | ESCC | 8.11e-33 | 7.10e-01 | 0.1122 |
100287932 | TIMM23 | P15T-E | Human | Esophagus | ESCC | 1.04e-28 | 7.43e-01 | 0.1149 |
100287932 | TIMM23 | P16T-E | Human | Esophagus | ESCC | 1.32e-17 | 3.55e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
GO:00718061 | Colorectum | SER | protein transmembrane transport | 17/2897 | 59/18723 | 6.64e-03 | 4.69e-02 | 17 |
GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM23 | SNV | Missense_Mutation | novel | c.209N>A | p.Arg70Gln | p.R70Q | O14925 | protein_coding | tolerated(0.05) | possibly_damaging(0.559) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TIMM23 | SNV | Missense_Mutation | novel | c.290G>A | p.Arg97Gln | p.R97Q | O14925 | protein_coding | tolerated(0.22) | benign(0.434) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIMM23 | SNV | Missense_Mutation | novel | c.289N>T | p.Arg97Trp | p.R97W | O14925 | protein_coding | tolerated(0.14) | probably_damaging(0.957) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM23 | SNV | Missense_Mutation | novel | c.146A>T | p.Asp49Val | p.D49V | O14925 | protein_coding | deleterious(0) | benign(0.084) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM23 | SNV | Missense_Mutation | rs150556806 | c.605N>A | p.Gly202Asp | p.G202D | O14925 | protein_coding | tolerated(0.11) | probably_damaging(0.999) | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIMM23 | SNV | Missense_Mutation | novel | c.193G>A | p.Gly65Arg | p.G65R | O14925 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DQ-7588-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | erbitux | PD |
TIMM23 | SNV | Missense_Mutation | novel | c.443C>T | p.Thr148Ile | p.T148I | O14925 | protein_coding | tolerated(0.38) | possibly_damaging(0.81) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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