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Gene: TIAM2 |
Gene summary for TIAM2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TIAM2 | Gene ID | 26230 |
Gene name | TIAM Rac1 associated GEF 2 | |
Gene Alias | STEF | |
Cytomap | 6q25.2-q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8IVF5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26230 | TIAM2 | AEH-subject1 | Human | Endometrium | AEH | 2.36e-08 | 3.13e-01 | -0.3059 |
26230 | TIAM2 | AEH-subject3 | Human | Endometrium | AEH | 2.08e-05 | 2.91e-01 | -0.2576 |
26230 | TIAM2 | AEH-subject4 | Human | Endometrium | AEH | 1.49e-03 | 2.58e-01 | -0.2657 |
26230 | TIAM2 | AEH-subject5 | Human | Endometrium | AEH | 5.69e-16 | 4.43e-01 | -0.2953 |
26230 | TIAM2 | EEC-subject1 | Human | Endometrium | EEC | 1.10e-06 | 3.30e-01 | -0.2682 |
26230 | TIAM2 | EEC-subject2 | Human | Endometrium | EEC | 2.21e-06 | 3.06e-01 | -0.2607 |
26230 | TIAM2 | EEC-subject4 | Human | Endometrium | EEC | 2.43e-06 | 3.08e-01 | -0.2571 |
26230 | TIAM2 | EEC-subject5 | Human | Endometrium | EEC | 2.70e-10 | 3.57e-01 | -0.249 |
26230 | TIAM2 | 047563_1562-all-cells | Human | Prostate | BPH | 1.04e-04 | 2.75e-01 | 0.0791 |
26230 | TIAM2 | 048752_1579-all-cells | Human | Prostate | BPH | 2.59e-27 | 5.88e-01 | 0.1008 |
26230 | TIAM2 | 052095_1628-all-cells | Human | Prostate | BPH | 1.68e-11 | 3.99e-01 | 0.1032 |
26230 | TIAM2 | 052097_1595-all-cells | Human | Prostate | BPH | 6.80e-12 | 3.50e-01 | 0.0972 |
26230 | TIAM2 | 052099_1652-all-cells | Human | Prostate | BPH | 2.75e-20 | 5.18e-01 | 0.1038 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Endometrium | AEH: Atypical endometrial hyperplasia | |
EEC: Endometrioid Cancer | ||
Prostate | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00074098 | Endometrium | AEH | axonogenesis | 81/2100 | 418/18723 | 5.54e-07 | 2.12e-05 | 81 |
GO:00615648 | Endometrium | AEH | axon development | 88/2100 | 467/18723 | 6.39e-07 | 2.38e-05 | 88 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:00510567 | Endometrium | AEH | regulation of small GTPase mediated signal transduction | 59/2100 | 302/18723 | 1.43e-05 | 3.03e-04 | 59 |
GO:00107207 | Endometrium | AEH | positive regulation of cell development | 57/2100 | 298/18723 | 3.72e-05 | 6.49e-04 | 57 |
GO:00109758 | Endometrium | AEH | regulation of neuron projection development | 75/2100 | 445/18723 | 2.01e-04 | 2.54e-03 | 75 |
GO:00435477 | Endometrium | AEH | positive regulation of GTPase activity | 48/2100 | 255/18723 | 2.18e-04 | 2.67e-03 | 48 |
GO:00313468 | Endometrium | AEH | positive regulation of cell projection organization | 61/2100 | 353/18723 | 3.91e-04 | 4.20e-03 | 61 |
GO:00507725 | Endometrium | AEH | positive regulation of axonogenesis | 17/2100 | 79/18723 | 5.93e-03 | 3.59e-02 | 17 |
GO:00906304 | Endometrium | AEH | activation of GTPase activity | 22/2100 | 115/18723 | 8.42e-03 | 4.60e-02 | 22 |
GO:00507677 | Endometrium | AEH | regulation of neurogenesis | 56/2100 | 364/18723 | 8.87e-03 | 4.82e-02 | 56 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
GO:000740912 | Endometrium | EEC | axonogenesis | 82/2168 | 418/18723 | 1.03e-06 | 3.49e-05 | 82 |
GO:005105612 | Endometrium | EEC | regulation of small GTPase mediated signal transduction | 61/2168 | 302/18723 | 9.42e-06 | 2.08e-04 | 61 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:001097513 | Endometrium | EEC | regulation of neuron projection development | 79/2168 | 445/18723 | 6.80e-05 | 1.01e-03 | 79 |
GO:004354712 | Endometrium | EEC | positive regulation of GTPase activity | 50/2168 | 255/18723 | 1.26e-04 | 1.66e-03 | 50 |
GO:001072012 | Endometrium | EEC | positive regulation of cell development | 56/2168 | 298/18723 | 1.68e-04 | 2.10e-03 | 56 |
GO:003134613 | Endometrium | EEC | positive regulation of cell projection organization | 61/2168 | 353/18723 | 8.82e-04 | 8.03e-03 | 61 |
GO:009063012 | Endometrium | EEC | activation of GTPase activity | 23/2168 | 115/18723 | 6.04e-03 | 3.57e-02 | 23 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIAM2 | insertion | Nonsense_Mutation | novel | c.550_551insCCTGAGGTCGGGAGTTTGAGAACAGTCTGACCAACAT | p.Ser184ThrfsTer2 | p.S184Tfs*2 | Q8IVF5 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TIAM2 | insertion | Nonsense_Mutation | novel | c.4892_4893insTATCATAAAATAAAATCTTAATGTTAAATCTTACACAAG | p.His1631_Phe1632insIleIleLysTerAsnLeuAsnValLysSerTyrThrSer | p.H1631_F1632insIIK*NLNVKSYTS | Q8IVF5 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TIAM2 | insertion | Frame_Shift_Ins | novel | c.3369_3370insATTCT | p.Leu1124IlefsTer53 | p.L1124Ifs*53 | Q8IVF5 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TIAM2 | insertion | Frame_Shift_Ins | novel | c.3607_3608insAACCTCTTTCA | p.Gly1203GlufsTer67 | p.G1203Efs*67 | Q8IVF5 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TIAM2 | insertion | Frame_Shift_Ins | novel | c.3609_3610insTTGTTTATATCCCACC | p.Phe1204LeufsTer9 | p.F1204Lfs*9 | Q8IVF5 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TIAM2 | insertion | Frame_Shift_Ins | novel | c.3286_3287insTGGATTGTATATTTCC | p.Asp1096ValfsTer33 | p.D1096Vfs*33 | Q8IVF5 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TIAM2 | insertion | Nonsense_Mutation | novel | c.4890_4891insTGTTCTTAAC | p.His1631CysfsTer3 | p.H1631Cfs*3 | Q8IVF5 | protein_coding | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TIAM2 | insertion | Frame_Shift_Ins | novel | c.4892_4893insCAGCATTTTGGGCAAAGTTGTAGACT | p.Phe1632SerfsTer48 | p.F1632Sfs*48 | Q8IVF5 | protein_coding | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TIAM2 | SNV | Missense_Mutation | c.3438N>G | p.Ser1146Arg | p.S1146R | Q8IVF5 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TIAM2 | SNV | Missense_Mutation | c.4381C>T | p.His1461Tyr | p.H1461Y | Q8IVF5 | protein_coding | deleterious(0.04) | benign(0.435) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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