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Gene: THAP6 |
Gene summary for THAP6 |
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Gene information | Species | Human | Gene symbol | THAP6 | Gene ID | 152815 |
Gene name | THAP domain containing 6 | |
Gene Alias | THAP6 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8TBB0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152815 | THAP6 | LZE4T | Human | Esophagus | ESCC | 9.29e-05 | 1.26e-01 | 0.0811 |
152815 | THAP6 | LZE24T | Human | Esophagus | ESCC | 1.96e-03 | 1.26e-01 | 0.0596 |
152815 | THAP6 | P2T-E | Human | Esophagus | ESCC | 6.34e-10 | 2.46e-01 | 0.1177 |
152815 | THAP6 | P4T-E | Human | Esophagus | ESCC | 7.12e-12 | 2.26e-01 | 0.1323 |
152815 | THAP6 | P5T-E | Human | Esophagus | ESCC | 8.70e-12 | 1.53e-01 | 0.1327 |
152815 | THAP6 | P8T-E | Human | Esophagus | ESCC | 3.80e-08 | 1.48e-01 | 0.0889 |
152815 | THAP6 | P9T-E | Human | Esophagus | ESCC | 9.36e-03 | 8.50e-02 | 0.1131 |
152815 | THAP6 | P10T-E | Human | Esophagus | ESCC | 1.18e-09 | 2.03e-01 | 0.116 |
152815 | THAP6 | P11T-E | Human | Esophagus | ESCC | 1.53e-07 | 3.06e-01 | 0.1426 |
152815 | THAP6 | P12T-E | Human | Esophagus | ESCC | 1.86e-07 | 1.80e-01 | 0.1122 |
152815 | THAP6 | P15T-E | Human | Esophagus | ESCC | 2.23e-11 | 1.87e-01 | 0.1149 |
152815 | THAP6 | P16T-E | Human | Esophagus | ESCC | 1.42e-10 | 2.83e-01 | 0.1153 |
152815 | THAP6 | P17T-E | Human | Esophagus | ESCC | 3.93e-03 | 1.90e-01 | 0.1278 |
152815 | THAP6 | P20T-E | Human | Esophagus | ESCC | 2.88e-11 | 1.74e-01 | 0.1124 |
152815 | THAP6 | P21T-E | Human | Esophagus | ESCC | 3.36e-09 | 1.96e-01 | 0.1617 |
152815 | THAP6 | P22T-E | Human | Esophagus | ESCC | 6.34e-11 | 1.66e-01 | 0.1236 |
152815 | THAP6 | P23T-E | Human | Esophagus | ESCC | 8.55e-11 | 1.47e-01 | 0.108 |
152815 | THAP6 | P24T-E | Human | Esophagus | ESCC | 8.88e-06 | 1.60e-01 | 0.1287 |
152815 | THAP6 | P26T-E | Human | Esophagus | ESCC | 1.41e-18 | 3.15e-01 | 0.1276 |
152815 | THAP6 | P27T-E | Human | Esophagus | ESCC | 2.47e-08 | 1.50e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THAP6 | deletion | Frame_Shift_Del | c.166delN | p.Gly58GlufsTer23 | p.G58Efs*23 | Q8TBB0 | protein_coding | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |||
THAP6 | deletion | Frame_Shift_Del | c.166delN | p.Gly58GlufsTer23 | p.G58Efs*23 | Q8TBB0 | protein_coding | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
THAP6 | SNV | Missense_Mutation | novel | c.626N>T | p.Trp209Leu | p.W209L | Q8TBB0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | c.422G>T | p.Ser141Ile | p.S141I | Q8TBB0 | protein_coding | tolerated(0.31) | probably_damaging(0.986) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP6 | SNV | Missense_Mutation | c.347C>T | p.Thr116Ile | p.T116I | Q8TBB0 | protein_coding | tolerated(0.18) | benign(0.02) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
THAP6 | SNV | Missense_Mutation | rs751948588 | c.121N>A | p.Ala41Thr | p.A41T | Q8TBB0 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | c.221G>C | p.Ser74Thr | p.S74T | Q8TBB0 | protein_coding | tolerated(1) | benign(0.003) | TCGA-75-6205-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD | |
THAP6 | SNV | Missense_Mutation | c.526N>C | p.Glu176Gln | p.E176Q | Q8TBB0 | protein_coding | deleterious(0.01) | possibly_damaging(0.683) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
THAP6 | SNV | Missense_Mutation | novel | c.223G>T | p.Ala75Ser | p.A75S | Q8TBB0 | protein_coding | tolerated(0.06) | benign(0.014) | TCGA-39-5011-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
THAP6 | SNV | Missense_Mutation | novel | c.14N>T | p.Cys5Phe | p.C5F | Q8TBB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-92-8064-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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