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Gene: THAP5 |
Gene summary for THAP5 |
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Gene information | Species | Human | Gene symbol | THAP5 | Gene ID | 168451 |
Gene name | THAP domain containing 5 | |
Gene Alias | THAP5 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q7Z6K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
168451 | THAP5 | LZE4T | Human | Esophagus | ESCC | 2.41e-02 | 1.16e-01 | 0.0811 |
168451 | THAP5 | LZE7T | Human | Esophagus | ESCC | 3.11e-03 | 1.95e-01 | 0.0667 |
168451 | THAP5 | LZE24T | Human | Esophagus | ESCC | 1.95e-03 | 9.92e-02 | 0.0596 |
168451 | THAP5 | P1T-E | Human | Esophagus | ESCC | 1.47e-06 | 4.74e-01 | 0.0875 |
168451 | THAP5 | P2T-E | Human | Esophagus | ESCC | 1.16e-10 | 1.64e-01 | 0.1177 |
168451 | THAP5 | P4T-E | Human | Esophagus | ESCC | 9.38e-11 | 3.39e-01 | 0.1323 |
168451 | THAP5 | P5T-E | Human | Esophagus | ESCC | 1.59e-06 | 1.00e-01 | 0.1327 |
168451 | THAP5 | P8T-E | Human | Esophagus | ESCC | 1.02e-11 | 1.98e-01 | 0.0889 |
168451 | THAP5 | P9T-E | Human | Esophagus | ESCC | 2.24e-09 | 2.42e-01 | 0.1131 |
168451 | THAP5 | P10T-E | Human | Esophagus | ESCC | 2.41e-15 | 2.70e-01 | 0.116 |
168451 | THAP5 | P11T-E | Human | Esophagus | ESCC | 5.89e-06 | 2.72e-01 | 0.1426 |
168451 | THAP5 | P12T-E | Human | Esophagus | ESCC | 1.17e-09 | 2.63e-01 | 0.1122 |
168451 | THAP5 | P15T-E | Human | Esophagus | ESCC | 1.88e-12 | 3.20e-01 | 0.1149 |
168451 | THAP5 | P16T-E | Human | Esophagus | ESCC | 6.24e-18 | 3.45e-01 | 0.1153 |
168451 | THAP5 | P17T-E | Human | Esophagus | ESCC | 3.04e-22 | 7.45e-01 | 0.1278 |
168451 | THAP5 | P19T-E | Human | Esophagus | ESCC | 2.01e-05 | 4.27e-01 | 0.1662 |
168451 | THAP5 | P20T-E | Human | Esophagus | ESCC | 7.26e-34 | 7.37e-01 | 0.1124 |
168451 | THAP5 | P21T-E | Human | Esophagus | ESCC | 4.63e-15 | 3.09e-01 | 0.1617 |
168451 | THAP5 | P22T-E | Human | Esophagus | ESCC | 2.60e-13 | 2.92e-01 | 0.1236 |
168451 | THAP5 | P24T-E | Human | Esophagus | ESCC | 2.06e-11 | 1.84e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:0045786 | Liver | HCC | negative regulation of cell cycle | 204/7958 | 385/18723 | 1.84e-05 | 1.99e-04 | 204 |
GO:004578613 | Skin | cSCC | negative regulation of cell cycle | 140/4864 | 385/18723 | 3.64e-06 | 5.50e-05 | 140 |
GO:00457867 | Thyroid | PTC | negative regulation of cell cycle | 166/5968 | 385/18723 | 1.93e-06 | 2.64e-05 | 166 |
GO:004578614 | Thyroid | ATC | negative regulation of cell cycle | 181/6293 | 385/18723 | 2.64e-08 | 5.07e-07 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THAP5 | SNV | Missense_Mutation | rs776851798 | c.1062N>C | p.Gln354His | p.Q354H | Q7Z6K1 | protein_coding | deleterious(0.01) | benign(0.28) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP5 | SNV | Missense_Mutation | c.294N>T | p.Lys98Asn | p.K98N | Q7Z6K1 | protein_coding | tolerated(0.4) | benign(0) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
THAP5 | insertion | Frame_Shift_Ins | rs769341401 | c.297_298insA | p.Ser100IlefsTer9 | p.S100Ifs*9 | Q7Z6K1 | protein_coding | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
THAP5 | SNV | Missense_Mutation | c.860C>T | p.Ser287Phe | p.S287F | Q7Z6K1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
THAP5 | SNV | Missense_Mutation | novel | c.218G>A | p.Arg73Gln | p.R73Q | Q7Z6K1 | protein_coding | tolerated(0.07) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP5 | SNV | Missense_Mutation | novel | c.772A>C | p.Asn258His | p.N258H | Q7Z6K1 | protein_coding | deleterious(0) | benign(0.275) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THAP5 | SNV | Missense_Mutation | rs796158447 | c.860C>A | p.Ser287Tyr | p.S287Y | Q7Z6K1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP5 | SNV | Missense_Mutation | c.833N>T | p.Ala278Val | p.A278V | Q7Z6K1 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP5 | SNV | Missense_Mutation | rs796158447 | c.860C>A | p.Ser287Tyr | p.S287Y | Q7Z6K1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP5 | SNV | Missense_Mutation | novel | c.869C>A | p.Ser290Tyr | p.S290Y | Q7Z6K1 | protein_coding | deleterious(0) | possibly_damaging(0.467) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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