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Gene: THAP2 |
Gene summary for THAP2 |
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Gene information | Species | Human | Gene symbol | THAP2 | Gene ID | 83591 |
Gene name | THAP domain containing 2 | |
Gene Alias | THAP2 | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H0W7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83591 | THAP2 | LZE4T | Human | Esophagus | ESCC | 1.02e-06 | 2.71e-01 | 0.0811 |
83591 | THAP2 | P1T-E | Human | Esophagus | ESCC | 5.25e-05 | 1.49e-01 | 0.0875 |
83591 | THAP2 | P2T-E | Human | Esophagus | ESCC | 1.12e-24 | 3.86e-01 | 0.1177 |
83591 | THAP2 | P4T-E | Human | Esophagus | ESCC | 1.58e-11 | 3.80e-01 | 0.1323 |
83591 | THAP2 | P5T-E | Human | Esophagus | ESCC | 2.52e-15 | 1.76e-01 | 0.1327 |
83591 | THAP2 | P8T-E | Human | Esophagus | ESCC | 1.64e-12 | 2.55e-01 | 0.0889 |
83591 | THAP2 | P9T-E | Human | Esophagus | ESCC | 3.02e-06 | 1.48e-01 | 0.1131 |
83591 | THAP2 | P10T-E | Human | Esophagus | ESCC | 3.37e-18 | 2.51e-01 | 0.116 |
83591 | THAP2 | P12T-E | Human | Esophagus | ESCC | 9.03e-16 | 1.96e-01 | 0.1122 |
83591 | THAP2 | P15T-E | Human | Esophagus | ESCC | 4.54e-06 | 1.73e-01 | 0.1149 |
83591 | THAP2 | P16T-E | Human | Esophagus | ESCC | 1.50e-10 | 9.80e-02 | 0.1153 |
83591 | THAP2 | P17T-E | Human | Esophagus | ESCC | 6.36e-03 | 1.64e-01 | 0.1278 |
83591 | THAP2 | P20T-E | Human | Esophagus | ESCC | 1.74e-15 | 4.88e-01 | 0.1124 |
83591 | THAP2 | P21T-E | Human | Esophagus | ESCC | 1.39e-17 | 3.52e-01 | 0.1617 |
83591 | THAP2 | P22T-E | Human | Esophagus | ESCC | 3.86e-03 | 9.98e-02 | 0.1236 |
83591 | THAP2 | P23T-E | Human | Esophagus | ESCC | 1.03e-16 | 5.41e-01 | 0.108 |
83591 | THAP2 | P24T-E | Human | Esophagus | ESCC | 4.18e-08 | 1.15e-01 | 0.1287 |
83591 | THAP2 | P26T-E | Human | Esophagus | ESCC | 1.52e-10 | 2.15e-01 | 0.1276 |
83591 | THAP2 | P27T-E | Human | Esophagus | ESCC | 4.39e-11 | 2.82e-01 | 0.1055 |
83591 | THAP2 | P28T-E | Human | Esophagus | ESCC | 1.68e-12 | 2.08e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THAP2 | SNV | Missense_Mutation | c.133N>A | p.Val45Met | p.V45M | Q9H0W7 | protein_coding | tolerated(0.08) | possibly_damaging(0.899) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THAP2 | SNV | Missense_Mutation | c.323N>A | p.Pro108Gln | p.P108Q | Q9H0W7 | protein_coding | deleterious(0.04) | benign(0.03) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THAP2 | SNV | Missense_Mutation | c.364N>T | p.Leu122Phe | p.L122F | Q9H0W7 | protein_coding | tolerated(0.64) | probably_damaging(0.916) | TCGA-AP-A05N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP2 | SNV | Missense_Mutation | c.209G>A | p.Arg70Gln | p.R70Q | Q9H0W7 | protein_coding | tolerated(0.06) | possibly_damaging(0.864) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP2 | insertion | Frame_Shift_Ins | novel | c.407dupA | p.Arg137GlufsTer4 | p.R137Efs*4 | Q9H0W7 | protein_coding | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
THAP2 | SNV | Missense_Mutation | c.677C>T | p.Thr226Ile | p.T226I | Q9H0W7 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
THAP2 | SNV | Missense_Mutation | c.494N>A | p.Arg165Lys | p.R165K | Q9H0W7 | protein_coding | tolerated(0.28) | benign(0) | TCGA-77-7463-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
THAP2 | SNV | Missense_Mutation | novel | c.224N>A | p.Ala75Asp | p.A75D | Q9H0W7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
THAP2 | SNV | Missense_Mutation | novel | c.249N>G | p.Cys83Trp | p.C83W | Q9H0W7 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-CQ-5333-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
THAP2 | SNV | Missense_Mutation | novel | c.211C>A | p.Leu71Ile | p.L71I | Q9H0W7 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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