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Gene: TFRC |
Gene summary for TFRC |
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Gene information | Species | Human | Gene symbol | TFRC | Gene ID | 7037 |
Gene name | transferrin receptor | |
Gene Alias | CD71 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | P02786 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7037 | TFRC | CA_HPV_1 | Human | Cervix | CC | 2.97e-03 | 2.03e-01 | 0.0264 |
7037 | TFRC | CA_HPV_2 | Human | Cervix | CC | 3.34e-03 | 3.43e-01 | 0.0391 |
7037 | TFRC | CCI_2 | Human | Cervix | CC | 1.20e-15 | 1.68e+00 | 0.5249 |
7037 | TFRC | CCI_3 | Human | Cervix | CC | 1.78e-12 | 1.01e+00 | 0.516 |
7037 | TFRC | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.23e-04 | -3.30e-01 | 0.0155 |
7037 | TFRC | HTA11_866_3004761011 | Human | Colorectum | AD | 4.22e-02 | -3.02e-01 | 0.096 |
7037 | TFRC | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.25e-08 | 6.93e-01 | 0.294 |
7037 | TFRC | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.91e-07 | 1.28e+00 | 0.3487 |
7037 | TFRC | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.16e-08 | 8.95e-01 | 0.281 |
7037 | TFRC | F007 | Human | Colorectum | FAP | 2.54e-03 | -3.41e-01 | 0.1176 |
7037 | TFRC | A001-C-207 | Human | Colorectum | FAP | 2.23e-03 | -2.21e-01 | 0.1278 |
7037 | TFRC | A015-C-203 | Human | Colorectum | FAP | 2.88e-15 | -2.38e-01 | -0.1294 |
7037 | TFRC | A015-C-204 | Human | Colorectum | FAP | 3.12e-06 | -2.56e-01 | -0.0228 |
7037 | TFRC | A014-C-040 | Human | Colorectum | FAP | 8.46e-03 | -3.76e-01 | -0.1184 |
7037 | TFRC | A002-C-201 | Human | Colorectum | FAP | 4.14e-11 | -1.88e-01 | 0.0324 |
7037 | TFRC | A002-C-203 | Human | Colorectum | FAP | 1.37e-02 | -1.92e-01 | 0.2786 |
7037 | TFRC | A001-C-119 | Human | Colorectum | FAP | 5.12e-11 | -3.69e-01 | -0.1557 |
7037 | TFRC | A001-C-108 | Human | Colorectum | FAP | 3.67e-10 | -3.13e-01 | -0.0272 |
7037 | TFRC | A002-C-205 | Human | Colorectum | FAP | 7.54e-18 | -3.43e-01 | -0.1236 |
7037 | TFRC | A015-C-005 | Human | Colorectum | FAP | 3.44e-03 | -2.13e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:005212610 | Cervix | CC | movement in host environment | 52/2311 | 175/18723 | 7.03e-10 | 8.76e-08 | 52 |
GO:004440910 | Cervix | CC | entry into host | 47/2311 | 151/18723 | 8.45e-10 | 1.03e-07 | 47 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:004671810 | Cervix | CC | viral entry into host cell | 44/2311 | 144/18723 | 5.47e-09 | 5.03e-07 | 44 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00420988 | Cervix | CC | T cell proliferation | 49/2311 | 199/18723 | 1.32e-06 | 4.49e-05 | 49 |
GO:003133410 | Cervix | CC | positive regulation of protein-containing complex assembly | 55/2311 | 237/18723 | 2.25e-06 | 6.73e-05 | 55 |
GO:00421297 | Cervix | CC | regulation of T cell proliferation | 43/2311 | 171/18723 | 3.21e-06 | 8.77e-05 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414520 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0421614 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0406618 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa04145110 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0421615 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0406619 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa042162 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa042163 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFRC | SNV | Missense_Mutation | rs141165322 | c.2257G>A | p.Val753Ile | p.V753I | P02786 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TFRC | SNV | Missense_Mutation | rs773087880 | c.313N>A | p.Glu105Lys | p.E105K | P02786 | protein_coding | tolerated(0.56) | benign(0.089) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TFRC | SNV | Missense_Mutation | c.229N>G | p.Phe77Val | p.F77V | P02786 | protein_coding | deleterious(0.01) | benign(0.292) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TFRC | SNV | Missense_Mutation | c.532C>T | p.Leu178Phe | p.L178F | P02786 | protein_coding | tolerated(0.06) | benign(0.022) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TFRC | SNV | Missense_Mutation | c.1937N>A | p.Arg646His | p.R646H | P02786 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TFRC | SNV | Missense_Mutation | rs768871682 | c.1780N>A | p.Ala594Thr | p.A594T | P02786 | protein_coding | deleterious(0.02) | benign(0.183) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFRC | SNV | Missense_Mutation | novel | c.2215N>G | p.Thr739Ala | p.T739A | P02786 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFRC | SNV | Missense_Mutation | rs746712619 | c.520C>T | p.Arg174Cys | p.R174C | P02786 | protein_coding | deleterious(0.02) | possibly_damaging(0.598) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFRC | SNV | Missense_Mutation | rs746712619 | c.520N>T | p.Arg174Cys | p.R174C | P02786 | protein_coding | deleterious(0.02) | possibly_damaging(0.598) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TFRC | SNV | Missense_Mutation | novel | c.2155N>A | p.Arg719Ser | p.R719S | P02786 | protein_coding | tolerated(0.32) | probably_damaging(0.965) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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