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Gene: TFEC |
Gene summary for TFEC |
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Gene information | Species | Human | Gene symbol | TFEC | Gene ID | 22797 |
Gene name | transcription factor EC | |
Gene Alias | TCFEC | |
Cytomap | 7q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O14948 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22797 | TFEC | Pt14.d | Human | Liver | HCC | 4.03e-02 | 1.54e-01 | 0.0143 |
22797 | TFEC | S027 | Human | Liver | HCC | 2.78e-14 | 1.01e+00 | 0.2446 |
22797 | TFEC | S028 | Human | Liver | HCC | 6.14e-17 | 8.54e-01 | 0.2503 |
22797 | TFEC | S029 | Human | Liver | HCC | 2.50e-18 | 5.76e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003460512 | Liver | HCC | cellular response to heat | 53/7958 | 69/18723 | 6.62e-09 | 1.70e-07 | 53 |
GO:000940811 | Liver | HCC | response to heat | 76/7958 | 110/18723 | 1.48e-08 | 3.58e-07 | 76 |
GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFEC | SNV | Missense_Mutation | c.900G>T | p.Glu300Asp | p.E300D | O14948 | protein_coding | tolerated(0.1) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TFEC | SNV | Missense_Mutation | rs200111306 | c.473G>A | p.Arg158Gln | p.R158Q | O14948 | protein_coding | deleterious(0.02) | benign(0.239) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TFEC | SNV | Missense_Mutation | rs376001735 | c.523C>T | p.Arg175Cys | p.R175C | O14948 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
TFEC | SNV | Missense_Mutation | c.466N>T | p.Asn156Tyr | p.N156Y | O14948 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
TFEC | deletion | Frame_Shift_Del | rs771133493 | c.422delN | p.Lys141ArgfsTer42 | p.K141Rfs*42 | O14948 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TFEC | insertion | Frame_Shift_Ins | novel | c.422_423insA | p.Asp142GlyfsTer7 | p.D142Gfs*7 | O14948 | protein_coding | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TFEC | deletion | Frame_Shift_Del | rs771133493 | c.422delA | p.Lys141ArgfsTer42 | p.K141Rfs*42 | O14948 | protein_coding | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | ||
TFEC | insertion | Frame_Shift_Ins | novel | c.422_423insA | p.Asp142GlyfsTer7 | p.D142Gfs*7 | O14948 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TFEC | SNV | Missense_Mutation | rs746353090 | c.190G>A | p.Val64Ile | p.V64I | O14948 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.158N>T | p.Arg53Ile | p.R53I | protein_coding | tolerated(0.09) | benign(0.2) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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