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Gene: TFCP2 |
Gene summary for TFCP2 |
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Gene information | Species | Human | Gene symbol | TFCP2 | Gene ID | 7024 |
Gene name | transcription factor CP2 | |
Gene Alias | LBP1C | |
Cytomap | 12q13.12-q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q12800 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7024 | TFCP2 | CCI_1 | Human | Cervix | CC | 2.03e-08 | 7.82e-01 | 0.528 |
7024 | TFCP2 | CCI_2 | Human | Cervix | CC | 4.85e-07 | 8.09e-01 | 0.5249 |
7024 | TFCP2 | CCI_3 | Human | Cervix | CC | 2.46e-13 | 8.04e-01 | 0.516 |
7024 | TFCP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.20e-06 | -2.58e-01 | 0.0155 |
7024 | TFCP2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.05e-02 | -5.33e-01 | -0.2061 |
7024 | TFCP2 | F007 | Human | Colorectum | FAP | 4.07e-03 | -2.55e-01 | 0.1176 |
7024 | TFCP2 | A001-C-207 | Human | Colorectum | FAP | 9.39e-05 | -2.10e-01 | 0.1278 |
7024 | TFCP2 | A015-C-203 | Human | Colorectum | FAP | 8.80e-30 | -4.77e-01 | -0.1294 |
7024 | TFCP2 | A015-C-204 | Human | Colorectum | FAP | 1.69e-07 | -2.96e-01 | -0.0228 |
7024 | TFCP2 | A014-C-040 | Human | Colorectum | FAP | 5.56e-06 | -4.47e-01 | -0.1184 |
7024 | TFCP2 | A002-C-201 | Human | Colorectum | FAP | 5.54e-16 | -3.89e-01 | 0.0324 |
7024 | TFCP2 | A002-C-203 | Human | Colorectum | FAP | 2.06e-03 | -8.56e-02 | 0.2786 |
7024 | TFCP2 | A001-C-119 | Human | Colorectum | FAP | 2.02e-06 | -2.69e-01 | -0.1557 |
7024 | TFCP2 | A001-C-108 | Human | Colorectum | FAP | 3.74e-16 | -2.95e-01 | -0.0272 |
7024 | TFCP2 | A002-C-205 | Human | Colorectum | FAP | 5.75e-25 | -4.60e-01 | -0.1236 |
7024 | TFCP2 | A001-C-104 | Human | Colorectum | FAP | 3.52e-04 | -1.45e-01 | 0.0184 |
7024 | TFCP2 | A015-C-005 | Human | Colorectum | FAP | 5.32e-05 | -2.55e-01 | -0.0336 |
7024 | TFCP2 | A015-C-006 | Human | Colorectum | FAP | 1.19e-14 | -2.65e-01 | -0.0994 |
7024 | TFCP2 | A015-C-106 | Human | Colorectum | FAP | 7.41e-09 | -2.22e-01 | -0.0511 |
7024 | TFCP2 | A002-C-114 | Human | Colorectum | FAP | 7.78e-21 | -4.51e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00459271 | Colorectum | SER | positive regulation of growth | 56/2897 | 259/18723 | 5.10e-03 | 3.91e-02 | 56 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
GO:00075681 | Colorectum | MSS | aging | 90/3467 | 339/18723 | 1.51e-04 | 2.19e-03 | 90 |
GO:00459272 | Colorectum | MSS | positive regulation of growth | 68/3467 | 259/18723 | 1.24e-03 | 1.19e-02 | 68 |
GO:00020644 | Colorectum | FAP | epithelial cell development | 62/2622 | 220/18723 | 2.74e-08 | 2.54e-06 | 62 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:00459273 | Colorectum | FAP | positive regulation of growth | 66/2622 | 259/18723 | 6.11e-07 | 3.05e-05 | 66 |
GO:00075682 | Colorectum | FAP | aging | 69/2622 | 339/18723 | 7.66e-04 | 8.12e-03 | 69 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:0007028 | Colorectum | FAP | cytoplasm organization | 5/2622 | 10/18723 | 7.32e-03 | 4.38e-02 | 5 |
GO:00020645 | Colorectum | CRC | epithelial cell development | 55/2078 | 220/18723 | 4.63e-09 | 1.16e-06 | 55 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00459274 | Colorectum | CRC | positive regulation of growth | 51/2078 | 259/18723 | 3.23e-05 | 8.27e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFCP2 | SNV | Missense_Mutation | novel | c.1201N>A | p.Leu401Met | p.L401M | Q12800 | protein_coding | tolerated(0.24) | benign(0.289) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TFCP2 | SNV | Missense_Mutation | rs563834540 | c.1016N>A | p.Arg339Gln | p.R339Q | Q12800 | protein_coding | tolerated(0.2) | benign(0.062) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TFCP2 | SNV | Missense_Mutation | rs563834540 | c.1016N>A | p.Arg339Gln | p.R339Q | Q12800 | protein_coding | tolerated(0.2) | benign(0.062) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFCP2 | SNV | Missense_Mutation | c.34N>A | p.Glu12Lys | p.E12K | Q12800 | protein_coding | tolerated_low_confidence(0.28) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TFCP2 | SNV | Missense_Mutation | novel | c.1011G>T | p.Leu337Phe | p.L337F | Q12800 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
TFCP2 | SNV | Missense_Mutation | rs769638214 | c.293N>A | p.Arg98Gln | p.R98Q | Q12800 | protein_coding | tolerated(0.07) | possibly_damaging(0.815) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TFCP2 | SNV | Missense_Mutation | rs563834540 | c.1016N>A | p.Arg339Gln | p.R339Q | Q12800 | protein_coding | tolerated(0.2) | benign(0.062) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TFCP2 | insertion | Frame_Shift_Ins | novel | c.1330_1331insA | p.Ile444AsnfsTer29 | p.I444Nfs*29 | Q12800 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
TFCP2 | SNV | Missense_Mutation | novel | c.1112N>T | p.Pro371Leu | p.P371L | Q12800 | protein_coding | tolerated(0.61) | benign(0.325) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TFCP2 | SNV | Missense_Mutation | novel | c.1042C>T | p.Leu348Phe | p.L348F | Q12800 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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