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Gene: TECPR1 |
Gene summary for TECPR1 |
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Gene information | Species | Human | Gene symbol | TECPR1 | Gene ID | 25851 |
Gene name | tectonin beta-propeller repeat containing 1 | |
Gene Alias | TECPR1 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q7Z6L1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25851 | TECPR1 | LZE7T | Human | Esophagus | ESCC | 2.49e-03 | 1.31e-01 | 0.0667 |
25851 | TECPR1 | LZE24T | Human | Esophagus | ESCC | 7.68e-07 | 7.92e-02 | 0.0596 |
25851 | TECPR1 | P1T-E | Human | Esophagus | ESCC | 6.34e-04 | 2.68e-01 | 0.0875 |
25851 | TECPR1 | P2T-E | Human | Esophagus | ESCC | 3.61e-05 | 1.39e-01 | 0.1177 |
25851 | TECPR1 | P4T-E | Human | Esophagus | ESCC | 9.70e-05 | 5.32e-02 | 0.1323 |
25851 | TECPR1 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 8.31e-02 | 0.1327 |
25851 | TECPR1 | P8T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.04e-01 | 0.0889 |
25851 | TECPR1 | P9T-E | Human | Esophagus | ESCC | 5.51e-03 | 3.86e-02 | 0.1131 |
25851 | TECPR1 | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 9.53e-02 | 0.116 |
25851 | TECPR1 | P11T-E | Human | Esophagus | ESCC | 3.21e-06 | 1.50e-01 | 0.1426 |
25851 | TECPR1 | P12T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.16e-01 | 0.1122 |
25851 | TECPR1 | P15T-E | Human | Esophagus | ESCC | 7.46e-09 | 1.65e-01 | 0.1149 |
25851 | TECPR1 | P16T-E | Human | Esophagus | ESCC | 4.29e-24 | 4.28e-01 | 0.1153 |
25851 | TECPR1 | P17T-E | Human | Esophagus | ESCC | 2.77e-04 | 1.95e-01 | 0.1278 |
25851 | TECPR1 | P19T-E | Human | Esophagus | ESCC | 3.38e-03 | 2.55e-01 | 0.1662 |
25851 | TECPR1 | P20T-E | Human | Esophagus | ESCC | 1.34e-12 | 1.63e-01 | 0.1124 |
25851 | TECPR1 | P21T-E | Human | Esophagus | ESCC | 3.68e-05 | 1.12e-01 | 0.1617 |
25851 | TECPR1 | P22T-E | Human | Esophagus | ESCC | 4.99e-03 | 7.51e-02 | 0.1236 |
25851 | TECPR1 | P23T-E | Human | Esophagus | ESCC | 1.89e-06 | 1.22e-01 | 0.108 |
25851 | TECPR1 | P26T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.07e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00973523 | Esophagus | ESCC | autophagosome maturation | 31/8552 | 40/18723 | 4.04e-05 | 3.26e-04 | 31 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:00973521 | Liver | HCC | autophagosome maturation | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:0016236110 | Thyroid | PTC | macroautophagy | 167/5968 | 291/18723 | 1.51e-19 | 1.91e-17 | 167 |
GO:0032984110 | Thyroid | PTC | protein-containing complex disassembly | 114/5968 | 224/18723 | 2.26e-09 | 6.33e-08 | 114 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
GO:003298422 | Thyroid | ATC | protein-containing complex disassembly | 121/6293 | 224/18723 | 2.25e-10 | 6.59e-09 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TECPR1 | SNV | Missense_Mutation | c.2826G>C | p.Glu942Asp | p.E942D | Q7Z6L1 | protein_coding | tolerated(0.6) | benign(0.076) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TECPR1 | SNV | Missense_Mutation | c.1561G>T | p.Gly521Cys | p.G521C | Q7Z6L1 | protein_coding | deleterious(0.02) | probably_damaging(0.944) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TECPR1 | SNV | Missense_Mutation | rs769357623 | c.2956N>A | p.Asp986Asn | p.D986N | Q7Z6L1 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TECPR1 | SNV | Missense_Mutation | rs776939148 | c.197N>A | p.Arg66His | p.R66H | Q7Z6L1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2671-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Other, specify in notesProtocol AMG 20060464 | study | PD |
TECPR1 | SNV | Missense_Mutation | rs375064994 | c.1007N>T | p.Thr336Met | p.T336M | Q7Z6L1 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TECPR1 | SNV | Missense_Mutation | rs570515591 | c.3034N>T | p.Arg1012Trp | p.R1012W | Q7Z6L1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | novel | c.1011N>T | p.Met337Ile | p.M337I | Q7Z6L1 | protein_coding | deleterious(0.02) | possibly_damaging(0.576) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | rs373953014 | c.3337G>A | p.Val1113Met | p.V1113M | Q7Z6L1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TECPR1 | SNV | Missense_Mutation | rs369859063 | c.1924G>A | p.Val642Ile | p.V642I | Q7Z6L1 | protein_coding | tolerated(0.19) | benign(0) | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
TECPR1 | SNV | Missense_Mutation | rs755077077 | c.2086C>T | p.Arg696Cys | p.R696C | Q7Z6L1 | protein_coding | tolerated(0.05) | benign(0.01) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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