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Gene: TCEA1 |
Gene summary for TCEA1 |
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Gene information | Species | Human | Gene symbol | TCEA1 | Gene ID | 6917 |
Gene name | transcription elongation factor A1 | |
Gene Alias | GTF2S | |
Cytomap | 8q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P23193 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6917 | TCEA1 | GSM4909281 | Human | Breast | IDC | 1.16e-03 | 2.79e-01 | 0.21 |
6917 | TCEA1 | GSM4909288 | Human | Breast | IDC | 2.43e-06 | 5.99e-03 | 0.0988 |
6917 | TCEA1 | GSM4909293 | Human | Breast | IDC | 1.24e-07 | 3.10e-01 | 0.1581 |
6917 | TCEA1 | GSM4909294 | Human | Breast | IDC | 1.38e-07 | 2.45e-01 | 0.2022 |
6917 | TCEA1 | GSM4909296 | Human | Breast | IDC | 7.51e-10 | -1.86e-01 | 0.1524 |
6917 | TCEA1 | GSM4909297 | Human | Breast | IDC | 3.24e-15 | -4.75e-02 | 0.1517 |
6917 | TCEA1 | GSM4909309 | Human | Breast | IDC | 1.14e-04 | -1.02e-01 | 0.0483 |
6917 | TCEA1 | GSM4909311 | Human | Breast | IDC | 9.77e-32 | -5.86e-02 | 0.1534 |
6917 | TCEA1 | GSM4909312 | Human | Breast | IDC | 1.10e-25 | 4.55e-01 | 0.1552 |
6917 | TCEA1 | GSM4909313 | Human | Breast | IDC | 4.69e-05 | 6.05e-02 | 0.0391 |
6917 | TCEA1 | GSM4909317 | Human | Breast | IDC | 1.87e-57 | 1.01e+00 | 0.1355 |
6917 | TCEA1 | GSM4909318 | Human | Breast | IDC | 6.73e-50 | 1.33e+00 | 0.2031 |
6917 | TCEA1 | GSM4909319 | Human | Breast | IDC | 5.76e-43 | -6.62e-02 | 0.1563 |
6917 | TCEA1 | GSM4909320 | Human | Breast | IDC | 1.66e-06 | -1.55e-01 | 0.1575 |
6917 | TCEA1 | GSM4909321 | Human | Breast | IDC | 8.06e-15 | -2.12e-01 | 0.1559 |
6917 | TCEA1 | M2 | Human | Breast | IDC | 9.09e-05 | 1.88e-01 | 0.21 |
6917 | TCEA1 | M5 | Human | Breast | IDC | 2.81e-03 | 5.54e-01 | 0.1598 |
6917 | TCEA1 | NCCBC14 | Human | Breast | DCIS | 5.83e-14 | 2.61e-02 | 0.2021 |
6917 | TCEA1 | NCCBC2 | Human | Breast | DCIS | 2.18e-10 | 8.27e-02 | 0.1554 |
6917 | TCEA1 | NCCBC5 | Human | Breast | DCIS | 2.52e-15 | -7.16e-02 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003206912 | Breast | IDC | regulation of nuclease activity | 8/1434 | 22/18723 | 1.40e-04 | 2.49e-03 | 8 |
GO:003206922 | Breast | DCIS | regulation of nuclease activity | 8/1390 | 22/18723 | 1.13e-04 | 2.00e-03 | 8 |
GO:00320698 | Esophagus | ESCC | regulation of nuclease activity | 19/8552 | 22/18723 | 9.52e-05 | 6.78e-04 | 19 |
GO:00320695 | Liver | Cirrhotic | regulation of nuclease activity | 11/4634 | 22/18723 | 9.18e-03 | 4.21e-02 | 11 |
GO:003206911 | Liver | HCC | regulation of nuclease activity | 18/7958 | 22/18723 | 1.91e-04 | 1.49e-03 | 18 |
GO:00320697 | Oral cavity | OSCC | regulation of nuclease activity | 20/7305 | 22/18723 | 6.02e-07 | 8.64e-06 | 20 |
GO:003206913 | Oral cavity | LP | regulation of nuclease activity | 14/4623 | 22/18723 | 1.23e-04 | 1.44e-03 | 14 |
GO:00320699 | Skin | cSCC | regulation of nuclease activity | 14/4864 | 22/18723 | 2.22e-04 | 1.83e-03 | 14 |
GO:003206914 | Thyroid | PTC | regulation of nuclease activity | 15/5968 | 22/18723 | 5.11e-04 | 3.32e-03 | 15 |
GO:003206923 | Thyroid | ATC | regulation of nuclease activity | 17/6293 | 22/18723 | 3.47e-05 | 2.84e-04 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCEA1 | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | P23193 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TCEA1 | SNV | Missense_Mutation | c.787T>C | p.Cys263Arg | p.C263R | P23193 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TCEA1 | SNV | Missense_Mutation | rs764364857 | c.458N>A | p.Arg153Gln | p.R153Q | P23193 | protein_coding | tolerated(0.73) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TCEA1 | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | P23193 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TCEA1 | SNV | Missense_Mutation | novel | c.466G>A | p.Asp156Asn | p.D156N | P23193 | protein_coding | tolerated(0.22) | benign(0.049) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TCEA1 | SNV | Missense_Mutation | novel | c.96G>T | p.Lys32Asn | p.K32N | P23193 | protein_coding | tolerated(0.15) | benign(0.248) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TCEA1 | SNV | Missense_Mutation | novel | c.161N>A | p.Arg54His | p.R54H | P23193 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A5-A0GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCEA1 | SNV | Missense_Mutation | novel | c.20G>A | p.Arg7His | p.R7H | P23193 | protein_coding | tolerated(0.1) | benign(0.082) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCEA1 | SNV | Missense_Mutation | novel | c.673N>T | p.Ala225Ser | p.A225S | P23193 | protein_coding | tolerated(0.26) | benign(0.173) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TCEA1 | SNV | Missense_Mutation | c.338N>C | p.Val113Ala | p.V113A | P23193 | protein_coding | tolerated(0.74) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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