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Gene: TCAIM |
Gene summary for TCAIM |
Gene summary. |
Gene information | Species | Human | Gene symbol | TCAIM | Gene ID | 285343 |
Gene name | T cell activation inhibitor, mitochondrial | |
Gene Alias | C3orf23 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R2R9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285343 | TCAIM | LZE4T | Human | Esophagus | ESCC | 1.06e-02 | 7.20e-02 | 0.0811 |
285343 | TCAIM | LZE24T | Human | Esophagus | ESCC | 2.84e-09 | 2.89e-01 | 0.0596 |
285343 | TCAIM | P2T-E | Human | Esophagus | ESCC | 3.73e-24 | 2.26e-01 | 0.1177 |
285343 | TCAIM | P4T-E | Human | Esophagus | ESCC | 5.84e-16 | 4.85e-01 | 0.1323 |
285343 | TCAIM | P5T-E | Human | Esophagus | ESCC | 4.33e-03 | 3.77e-02 | 0.1327 |
285343 | TCAIM | P8T-E | Human | Esophagus | ESCC | 2.54e-08 | 9.16e-02 | 0.0889 |
285343 | TCAIM | P9T-E | Human | Esophagus | ESCC | 4.04e-04 | 9.65e-02 | 0.1131 |
285343 | TCAIM | P10T-E | Human | Esophagus | ESCC | 4.28e-15 | 2.36e-01 | 0.116 |
285343 | TCAIM | P11T-E | Human | Esophagus | ESCC | 8.07e-04 | 1.63e-01 | 0.1426 |
285343 | TCAIM | P12T-E | Human | Esophagus | ESCC | 8.29e-14 | 2.59e-01 | 0.1122 |
285343 | TCAIM | P15T-E | Human | Esophagus | ESCC | 6.15e-03 | 1.49e-01 | 0.1149 |
285343 | TCAIM | P16T-E | Human | Esophagus | ESCC | 1.78e-05 | 1.21e-01 | 0.1153 |
285343 | TCAIM | P20T-E | Human | Esophagus | ESCC | 2.66e-09 | 2.37e-01 | 0.1124 |
285343 | TCAIM | P21T-E | Human | Esophagus | ESCC | 5.34e-23 | 4.80e-01 | 0.1617 |
285343 | TCAIM | P22T-E | Human | Esophagus | ESCC | 2.76e-03 | 2.15e-02 | 0.1236 |
285343 | TCAIM | P23T-E | Human | Esophagus | ESCC | 2.65e-08 | 2.11e-01 | 0.108 |
285343 | TCAIM | P24T-E | Human | Esophagus | ESCC | 2.00e-07 | 2.29e-01 | 0.1287 |
285343 | TCAIM | P26T-E | Human | Esophagus | ESCC | 2.70e-20 | 2.02e-01 | 0.1276 |
285343 | TCAIM | P27T-E | Human | Esophagus | ESCC | 2.09e-10 | 1.66e-01 | 0.1055 |
285343 | TCAIM | P28T-E | Human | Esophagus | ESCC | 1.01e-12 | 2.47e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCAIM | SNV | Missense_Mutation | c.649C>T | p.Arg217Cys | p.R217C | Q8N3R3 | protein_coding | deleterious(0.04) | probably_damaging(0.979) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TCAIM | SNV | Missense_Mutation | novel | c.104N>T | p.Ala35Val | p.A35V | Q8N3R3 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCAIM | SNV | Missense_Mutation | novel | c.484N>G | p.Lys162Glu | p.K162E | Q8N3R3 | protein_coding | deleterious(0.01) | benign(0.385) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCAIM | SNV | Missense_Mutation | novel | c.1237A>G | p.Lys413Glu | p.K413E | Q8N3R3 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TCAIM | SNV | Missense_Mutation | novel | c.231N>A | p.Phe77Leu | p.F77L | Q8N3R3 | protein_coding | tolerated(0.46) | benign(0.022) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCAIM | SNV | Missense_Mutation | c.305N>A | p.Pro102His | p.P102H | Q8N3R3 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TCAIM | SNV | Missense_Mutation | novel | c.32T>C | p.Leu11Ser | p.L11S | Q8N3R3 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.776) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCAIM | SNV | Missense_Mutation | novel | c.155C>T | p.Pro52Leu | p.P52L | Q8N3R3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TCAIM | SNV | Missense_Mutation | c.649N>T | p.Arg217Cys | p.R217C | Q8N3R3 | protein_coding | deleterious(0.04) | probably_damaging(0.979) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
TCAIM | SNV | Missense_Mutation | c.649N>T | p.Arg217Cys | p.R217C | Q8N3R3 | protein_coding | deleterious(0.04) | probably_damaging(0.979) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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