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Gene: TBXAS1 |
Gene summary for TBXAS1 |
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Gene information | Species | Human | Gene symbol | TBXAS1 | Gene ID | 6916 |
Gene name | thromboxane A synthase 1 | |
Gene Alias | BDPLT14 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0001516 | UniProtAcc | P24557 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6916 | TBXAS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.97e-11 | 4.44e-01 | -0.0811 |
6916 | TBXAS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.57e-09 | 4.33e-01 | -0.1088 |
6916 | TBXAS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.15e-05 | 2.82e-01 | -0.1954 |
6916 | TBXAS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.74e-08 | 3.62e-01 | -0.1464 |
6916 | TBXAS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.70e-12 | 4.52e-01 | -0.059 |
6916 | TBXAS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.62e-03 | 3.06e-01 | -0.0842 |
6916 | TBXAS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.75e-12 | 4.04e-01 | 0.096 |
6916 | TBXAS1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-03 | 5.70e-01 | 0.0446 |
6916 | TBXAS1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.11e-04 | 3.16e-01 | 0.0674 |
6916 | TBXAS1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.85e-05 | 3.75e-01 | 0.0112 |
6916 | TBXAS1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.13e-33 | 1.15e+00 | 0.0588 |
6916 | TBXAS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.22e-16 | 4.74e-01 | 0.294 |
6916 | TBXAS1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-16 | 6.13e-01 | 0.281 |
6916 | TBXAS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.48e-11 | 5.25e-01 | 0.3859 |
6916 | TBXAS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.35e-05 | 3.04e-01 | 0.2585 |
6916 | TBXAS1 | A002-C-010 | Human | Colorectum | FAP | 3.51e-07 | 4.39e-01 | 0.242 |
6916 | TBXAS1 | A015-C-203 | Human | Colorectum | FAP | 2.74e-03 | 3.18e-01 | -0.1294 |
6916 | TBXAS1 | A002-C-201 | Human | Colorectum | FAP | 3.88e-03 | 3.60e-01 | 0.0324 |
6916 | TBXAS1 | A002-C-203 | Human | Colorectum | FAP | 8.75e-34 | 8.94e-01 | 0.2786 |
6916 | TBXAS1 | A001-C-108 | Human | Colorectum | FAP | 1.42e-03 | 3.59e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:00066311 | Colorectum | SER | fatty acid metabolic process | 79/2897 | 390/18723 | 6.34e-03 | 4.56e-02 | 79 |
GO:00973051 | Colorectum | MSS | response to alcohol | 66/3467 | 253/18723 | 1.73e-03 | 1.54e-02 | 66 |
GO:00066312 | Colorectum | MSS | fatty acid metabolic process | 95/3467 | 390/18723 | 2.20e-03 | 1.84e-02 | 95 |
GO:0070542 | Colorectum | MSS | response to fatty acid | 21/3467 | 64/18723 | 4.39e-03 | 3.11e-02 | 21 |
GO:0046394 | Colorectum | MSS | carboxylic acid biosynthetic process | 76/3467 | 314/18723 | 6.71e-03 | 4.38e-02 | 76 |
GO:0016053 | Colorectum | MSS | organic acid biosynthetic process | 76/3467 | 316/18723 | 7.88e-03 | 4.84e-02 | 76 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00973053 | Colorectum | FAP | response to alcohol | 55/2622 | 253/18723 | 5.05e-04 | 5.78e-03 | 55 |
GO:0003018 | Colorectum | FAP | vascular process in circulatory system | 56/2622 | 263/18723 | 7.67e-04 | 8.12e-03 | 56 |
GO:00066314 | Colorectum | CRC | fatty acid metabolic process | 65/2078 | 390/18723 | 5.30e-04 | 7.42e-03 | 65 |
GO:00030181 | Colorectum | CRC | vascular process in circulatory system | 45/2078 | 263/18723 | 2.10e-03 | 2.08e-02 | 45 |
GO:00973054 | Colorectum | CRC | response to alcohol | 43/2078 | 253/18723 | 2.96e-03 | 2.66e-02 | 43 |
GO:1903522 | Colorectum | CRC | regulation of blood circulation | 43/2078 | 256/18723 | 3.70e-03 | 3.12e-02 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04611 | Colorectum | FAP | Platelet activation | 32/1404 | 124/8465 | 5.67e-03 | 2.18e-02 | 1.32e-02 | 32 |
hsa046111 | Colorectum | FAP | Platelet activation | 32/1404 | 124/8465 | 5.67e-03 | 2.18e-02 | 1.32e-02 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBXAS1 | insertion | Frame_Shift_Ins | novel | c.1670_1671insCTCCCAA | p.Pro558SerfsTer68 | p.P558Sfs*68 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TBXAS1 | insertion | Frame_Shift_Ins | novel | c.1553_1554insGGGACCATCCACAGGAGGGAGGGGACAGATGCCAGGCAGCAGGG | p.Phe519GlyfsTer28 | p.F519Gfs*28 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |||
TBXAS1 | SNV | Missense_Mutation | novel | c.1614N>C | p.Leu538Phe | p.L538F | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TBXAS1 | SNV | Missense_Mutation | c.1084C>T | p.Arg362Trp | p.R362W | protein_coding | deleterious(0.02) | possibly_damaging(0.809) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TBXAS1 | SNV | Missense_Mutation | c.759N>T | p.Glu253Asp | p.E253D | protein_coding | tolerated(0.88) | benign(0.027) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
TBXAS1 | SNV | Missense_Mutation | c.19T>C | p.Phe7Leu | p.F7L | protein_coding | tolerated_low_confidence(0.54) | benign(0) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TBXAS1 | SNV | Missense_Mutation | rs761419784 | c.964C>T | p.Arg322Trp | p.R322W | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6899-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TBXAS1 | SNV | Missense_Mutation | rs78666490 | c.1340C>T | p.Thr447Met | p.T447M | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
TBXAS1 | SNV | Missense_Mutation | c.661N>A | p.Asp221Asn | p.D221N | protein_coding | tolerated(0.3) | benign(0.015) | TCGA-CM-6170-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TBXAS1 | SNV | Missense_Mutation | rs373695119 | c.643N>T | p.Arg215Cys | p.R215C | protein_coding | tolerated(0.06) | possibly_damaging(0.823) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | NV-52 | |||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | E-6700 | |||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | EV-077 | |||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | aspirin | ASPIRIN | 21449675 | |
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | PYRIDINE | PYRIDINE | ||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | inhibitor | 363894160 | OZAGREL | |
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | ONO-1301 | |||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | inhibitor | 252827453 | ||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | NV-52 | |||
6916 | TBXAS1 | DRUGGABLE GENOME, CYTOCHROME P450, ENZYME | PMA | 7488650 |
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