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Gene: TBC1D10A |
Gene summary for TBC1D10A |
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Gene information | Species | Human | Gene symbol | TBC1D10A | Gene ID | 83874 |
Gene name | TBC1 domain family member 10A | |
Gene Alias | EPI64 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A7E244 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83874 | TBC1D10A | LZE4T | Human | Esophagus | ESCC | 3.59e-05 | 1.42e-01 | 0.0811 |
83874 | TBC1D10A | LZE7T | Human | Esophagus | ESCC | 1.22e-05 | 2.77e-01 | 0.0667 |
83874 | TBC1D10A | LZE8T | Human | Esophagus | ESCC | 5.46e-10 | 2.67e-01 | 0.067 |
83874 | TBC1D10A | LZE24T | Human | Esophagus | ESCC | 6.38e-14 | 3.36e-01 | 0.0596 |
83874 | TBC1D10A | LZE21T | Human | Esophagus | ESCC | 1.23e-02 | 2.75e-01 | 0.0655 |
83874 | TBC1D10A | P1T-E | Human | Esophagus | ESCC | 3.32e-07 | 2.75e-01 | 0.0875 |
83874 | TBC1D10A | P2T-E | Human | Esophagus | ESCC | 1.53e-24 | 4.10e-01 | 0.1177 |
83874 | TBC1D10A | P4T-E | Human | Esophagus | ESCC | 4.11e-10 | 2.79e-01 | 0.1323 |
83874 | TBC1D10A | P5T-E | Human | Esophagus | ESCC | 9.22e-05 | 9.10e-02 | 0.1327 |
83874 | TBC1D10A | P8T-E | Human | Esophagus | ESCC | 1.88e-21 | 3.74e-01 | 0.0889 |
83874 | TBC1D10A | P9T-E | Human | Esophagus | ESCC | 4.65e-07 | 1.88e-01 | 0.1131 |
83874 | TBC1D10A | P10T-E | Human | Esophagus | ESCC | 2.58e-23 | 3.51e-01 | 0.116 |
83874 | TBC1D10A | P11T-E | Human | Esophagus | ESCC | 7.81e-16 | 7.46e-01 | 0.1426 |
83874 | TBC1D10A | P12T-E | Human | Esophagus | ESCC | 4.71e-15 | 2.91e-01 | 0.1122 |
83874 | TBC1D10A | P15T-E | Human | Esophagus | ESCC | 6.40e-18 | 3.95e-01 | 0.1149 |
83874 | TBC1D10A | P16T-E | Human | Esophagus | ESCC | 1.11e-14 | 2.56e-01 | 0.1153 |
83874 | TBC1D10A | P17T-E | Human | Esophagus | ESCC | 2.07e-04 | 4.06e-01 | 0.1278 |
83874 | TBC1D10A | P19T-E | Human | Esophagus | ESCC | 4.69e-03 | 2.85e-01 | 0.1662 |
83874 | TBC1D10A | P20T-E | Human | Esophagus | ESCC | 6.56e-27 | 7.11e-01 | 0.1124 |
83874 | TBC1D10A | P21T-E | Human | Esophagus | ESCC | 9.40e-20 | 4.49e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:2000116111 | Esophagus | ESCC | regulation of cysteine-type endopeptidase activity | 158/8552 | 235/18723 | 1.67e-11 | 5.90e-10 | 158 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:0010952111 | Esophagus | ESCC | positive regulation of peptidase activity | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:0052548111 | Esophagus | ESCC | regulation of endopeptidase activity | 253/8552 | 432/18723 | 3.68e-08 | 6.78e-07 | 253 |
GO:0010950111 | Esophagus | ESCC | positive regulation of endopeptidase activity | 116/8552 | 179/18723 | 1.77e-07 | 2.79e-06 | 116 |
GO:00421477 | Esophagus | ESCC | retrograde transport, endosome to Golgi | 63/8552 | 91/18723 | 4.58e-06 | 4.87e-05 | 63 |
GO:2001056110 | Esophagus | ESCC | positive regulation of cysteine-type endopeptidase activity | 94/8552 | 148/18723 | 8.87e-06 | 8.59e-05 | 94 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:200011620 | Oral cavity | OSCC | regulation of cysteine-type endopeptidase activity | 152/7305 | 235/18723 | 1.14e-15 | 8.13e-14 | 152 |
GO:005254720 | Oral cavity | OSCC | regulation of peptidase activity | 255/7305 | 461/18723 | 5.78e-13 | 2.75e-11 | 255 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
GO:001095220 | Oral cavity | OSCC | positive regulation of peptidase activity | 123/7305 | 197/18723 | 2.12e-11 | 7.21e-10 | 123 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:005254820 | Oral cavity | OSCC | regulation of endopeptidase activity | 235/7305 | 432/18723 | 4.35e-11 | 1.40e-09 | 235 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D10A | SNV | Missense_Mutation | novel | c.1193N>T | p.Lys398Met | p.K398M | Q9BXI6 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
TBC1D10A | SNV | Missense_Mutation | novel | c.731C>T | p.Ala244Val | p.A244V | Q9BXI6 | protein_coding | deleterious(0) | possibly_damaging(0.59) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
TBC1D10A | SNV | Missense_Mutation | novel | c.15N>A | p.Asn5Lys | p.N5K | Q9BXI6 | protein_coding | tolerated_low_confidence(0.93) | benign(0) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D10A | SNV | Missense_Mutation | novel | c.1378N>A | p.Gln460Lys | p.Q460K | Q9BXI6 | protein_coding | tolerated_low_confidence(0.96) | benign(0.038) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TBC1D10A | SNV | Missense_Mutation | c.1525N>A | p.Glu509Lys | p.E509K | Q9BXI6 | protein_coding | deleterious_low_confidence(0.01) | benign(0.073) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TBC1D10A | SNV | Missense_Mutation | c.370C>T | p.Arg124Trp | p.R124W | Q9BXI6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D10A | SNV | Missense_Mutation | novel | c.1427N>G | p.Val476Gly | p.V476G | Q9BXI6 | protein_coding | tolerated_low_confidence(0.3) | benign(0.01) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
TBC1D10A | SNV | Missense_Mutation | c.1111N>A | p.Glu371Lys | p.E371K | Q9BXI6 | protein_coding | deleterious(0) | possibly_damaging(0.475) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TBC1D10A | SNV | Missense_Mutation | rs569436004 | c.334N>T | p.Arg112Cys | p.R112C | Q9BXI6 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TBC1D10A | SNV | Missense_Mutation | c.1111N>A | p.Glu371Lys | p.E371K | Q9BXI6 | protein_coding | deleterious(0) | possibly_damaging(0.475) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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