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Gene: SYT12 |
Gene summary for SYT12 |
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Gene information | Species | Human | Gene symbol | SYT12 | Gene ID | 91683 |
Gene name | synaptotagmin 12 | |
Gene Alias | SYT11 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | B0AZL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91683 | SYT12 | male-WTA | Human | Thyroid | PTC | 1.17e-31 | 4.14e-01 | 0.1037 |
91683 | SYT12 | PTC01 | Human | Thyroid | PTC | 3.77e-15 | 3.25e-01 | 0.1899 |
91683 | SYT12 | PTC04 | Human | Thyroid | PTC | 2.77e-07 | 1.72e-01 | 0.1927 |
91683 | SYT12 | PTC05 | Human | Thyroid | PTC | 5.09e-25 | 9.26e-01 | 0.2065 |
91683 | SYT12 | PTC06 | Human | Thyroid | PTC | 2.39e-47 | 1.07e+00 | 0.2057 |
91683 | SYT12 | PTC07 | Human | Thyroid | PTC | 1.15e-38 | 6.71e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010038112 | Thyroid | PTC | response to metal ion | 157/5968 | 373/18723 | 1.80e-05 | 1.86e-04 | 157 |
GO:005159219 | Thyroid | PTC | response to calcium ion | 65/5968 | 149/18723 | 1.67e-03 | 9.16e-03 | 65 |
GO:0071241110 | Thyroid | PTC | cellular response to inorganic substance | 92/5968 | 226/18723 | 3.01e-03 | 1.49e-02 | 92 |
GO:0071248110 | Thyroid | PTC | cellular response to metal ion | 78/5968 | 197/18723 | 1.29e-02 | 4.98e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYT12 | SNV | Missense_Mutation | c.1011G>T | p.Lys337Asn | p.K337N | Q8IV01 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SYT12 | SNV | Missense_Mutation | rs748388854 | c.1070N>T | p.Ser357Leu | p.S357L | Q8IV01 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SYT12 | SNV | Missense_Mutation | c.880N>A | p.Leu294Ile | p.L294I | Q8IV01 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SYT12 | SNV | Missense_Mutation | rs780429024 | c.562G>A | p.Glu188Lys | p.E188K | Q8IV01 | protein_coding | tolerated(0.63) | benign(0.183) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SYT12 | SNV | Missense_Mutation | rs201594640 | c.706N>T | p.Arg236Trp | p.R236W | Q8IV01 | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SYT12 | SNV | Missense_Mutation | c.1146N>A | p.Asp382Glu | p.D382E | Q8IV01 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SYT12 | SNV | Missense_Mutation | c.253N>T | p.Arg85Trp | p.R85W | Q8IV01 | protein_coding | deleterious_low_confidence(0) | benign(0.249) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SYT12 | SNV | Missense_Mutation | rs753483556 | c.743A>G | p.Asn248Ser | p.N248S | Q8IV01 | protein_coding | tolerated(0.23) | benign(0.033) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SYT12 | deletion | Frame_Shift_Del | c.45delN | p.Pro17LeufsTer21 | p.P17Lfs*21 | Q8IV01 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SYT12 | deletion | Frame_Shift_Del | c.368delN | p.Tyr125MetfsTer13 | p.Y125Mfs*13 | Q8IV01 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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