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Gene: SUOX |
Gene summary for SUOX |
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Gene information | Species | Human | Gene symbol | SUOX | Gene ID | 6821 |
Gene name | sulfite oxidase | |
Gene Alias | SUOX | |
Cytomap | 12q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | A0A024RB79 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6821 | SUOX | LZE24T | Human | Esophagus | ESCC | 1.37e-06 | 1.96e-01 | 0.0596 |
6821 | SUOX | P2T-E | Human | Esophagus | ESCC | 1.14e-16 | 2.06e-01 | 0.1177 |
6821 | SUOX | P4T-E | Human | Esophagus | ESCC | 7.45e-08 | 1.99e-01 | 0.1323 |
6821 | SUOX | P5T-E | Human | Esophagus | ESCC | 4.25e-03 | 8.71e-02 | 0.1327 |
6821 | SUOX | P8T-E | Human | Esophagus | ESCC | 1.97e-18 | 1.43e-01 | 0.0889 |
6821 | SUOX | P12T-E | Human | Esophagus | ESCC | 8.05e-10 | 2.07e-01 | 0.1122 |
6821 | SUOX | P15T-E | Human | Esophagus | ESCC | 8.39e-04 | 1.01e-01 | 0.1149 |
6821 | SUOX | P16T-E | Human | Esophagus | ESCC | 1.31e-08 | 1.26e-01 | 0.1153 |
6821 | SUOX | P20T-E | Human | Esophagus | ESCC | 3.07e-02 | 8.50e-02 | 0.1124 |
6821 | SUOX | P22T-E | Human | Esophagus | ESCC | 3.88e-03 | 7.29e-02 | 0.1236 |
6821 | SUOX | P23T-E | Human | Esophagus | ESCC | 3.83e-08 | 2.12e-01 | 0.108 |
6821 | SUOX | P24T-E | Human | Esophagus | ESCC | 3.40e-02 | 4.45e-02 | 0.1287 |
6821 | SUOX | P27T-E | Human | Esophagus | ESCC | 1.55e-09 | 1.60e-01 | 0.1055 |
6821 | SUOX | P30T-E | Human | Esophagus | ESCC | 2.91e-04 | 1.72e-01 | 0.137 |
6821 | SUOX | P32T-E | Human | Esophagus | ESCC | 6.74e-05 | 6.27e-02 | 0.1666 |
6821 | SUOX | P36T-E | Human | Esophagus | ESCC | 6.53e-03 | 1.42e-01 | 0.1187 |
6821 | SUOX | P37T-E | Human | Esophagus | ESCC | 1.27e-02 | 1.23e-01 | 0.1371 |
6821 | SUOX | P39T-E | Human | Esophagus | ESCC | 4.13e-03 | 6.44e-02 | 0.0894 |
6821 | SUOX | P40T-E | Human | Esophagus | ESCC | 9.64e-03 | 1.25e-01 | 0.109 |
6821 | SUOX | P42T-E | Human | Esophagus | ESCC | 1.01e-09 | 3.04e-01 | 0.1175 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUOX | SNV | Missense_Mutation | novel | c.468N>C | p.Lys156Asn | p.K156N | P51687 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SUOX | SNV | Missense_Mutation | c.883N>A | p.Gly295Arg | p.G295R | P51687 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SUOX | SNV | Missense_Mutation | c.1381N>C | p.Asp461His | p.D461H | P51687 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SUOX | SNV | Missense_Mutation | c.1556N>T | p.Pro519Leu | p.P519L | P51687 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A8QM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
SUOX | SNV | Missense_Mutation | c.457N>T | p.Ala153Ser | p.A153S | P51687 | protein_coding | tolerated(0.21) | benign(0.007) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SUOX | SNV | Missense_Mutation | rs535313141 | c.575G>A | p.Arg192Gln | p.R192Q | P51687 | protein_coding | tolerated(0.12) | benign(0.012) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SUOX | SNV | Missense_Mutation | c.296G>T | p.Gly99Val | p.G99V | P51687 | protein_coding | tolerated(0.09) | possibly_damaging(0.678) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SUOX | SNV | Missense_Mutation | c.1162C>T | p.Pro388Ser | p.P388S | P51687 | protein_coding | tolerated(0.59) | benign(0) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SUOX | SNV | Missense_Mutation | c.194N>A | p.Gly65Asp | p.G65D | P51687 | protein_coding | deleterious(0.02) | probably_damaging(0.946) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SUOX | SNV | Missense_Mutation | rs121908007 | c.650N>A | p.Arg217Gln | p.R217Q | P51687 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6323-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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