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Gene: STYK1 |
Gene summary for STYK1 |
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Gene information | Species | Human | Gene symbol | STYK1 | Gene ID | 55359 |
Gene name | serine/threonine/tyrosine kinase 1 | |
Gene Alias | NOK | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q6J9G0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55359 | STYK1 | CCI_1 | Human | Cervix | CC | 1.50e-10 | 7.46e-01 | 0.528 |
55359 | STYK1 | CCI_2 | Human | Cervix | CC | 2.16e-02 | 3.46e-01 | 0.5249 |
55359 | STYK1 | CCI_3 | Human | Cervix | CC | 3.64e-06 | 5.62e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STYK1 | SNV | Missense_Mutation | c.824A>C | p.Glu275Ala | p.E275A | Q6J9G0 | protein_coding | deleterious(0.04) | possibly_damaging(0.758) | TCGA-RU-A8FL-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
STYK1 | SNV | Missense_Mutation | rs747238411 | c.389N>A | p.Arg130Gln | p.R130Q | Q6J9G0 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.935N>C | p.Phe312Ser | p.F312S | Q6J9G0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
STYK1 | SNV | Missense_Mutation | novel | c.1223N>G | p.Ala408Gly | p.A408G | Q6J9G0 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.464N>C | p.Leu155Pro | p.L155P | Q6J9G0 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.278A>G | p.Glu93Gly | p.E93G | Q6J9G0 | protein_coding | deleterious(0.02) | benign(0.018) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.1049N>T | p.Ser350Ile | p.S350I | Q6J9G0 | protein_coding | deleterious(0) | possibly_damaging(0.514) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | c.63N>T | p.Glu21Asp | p.E21D | Q6J9G0 | protein_coding | tolerated(0.35) | benign(0.058) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
STYK1 | SNV | Missense_Mutation | novel | c.907G>A | p.Ala303Thr | p.A303T | Q6J9G0 | protein_coding | tolerated(0.08) | benign(0.312) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
STYK1 | SNV | Missense_Mutation | novel | c.477A>C | p.Gln159His | p.Q159H | Q6J9G0 | protein_coding | tolerated(0.29) | benign(0.109) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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