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Gene: STMN3 |
Gene summary for STMN3 |
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Gene information | Species | Human | Gene symbol | STMN3 | Gene ID | 50861 |
Gene name | stathmin 3 | |
Gene Alias | SCLIP | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9NZ72 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50861 | STMN3 | LZE4T | Human | Esophagus | ESCC | 5.01e-03 | 2.36e-01 | 0.0811 |
50861 | STMN3 | LZE8T | Human | Esophagus | ESCC | 1.77e-02 | 1.56e-01 | 0.067 |
50861 | STMN3 | P2T-E | Human | Esophagus | ESCC | 6.96e-09 | 2.13e-01 | 0.1177 |
50861 | STMN3 | P4T-E | Human | Esophagus | ESCC | 2.06e-04 | 1.52e-01 | 0.1323 |
50861 | STMN3 | P9T-E | Human | Esophagus | ESCC | 1.37e-06 | 2.21e-01 | 0.1131 |
50861 | STMN3 | P10T-E | Human | Esophagus | ESCC | 1.29e-31 | 6.10e-01 | 0.116 |
50861 | STMN3 | P11T-E | Human | Esophagus | ESCC | 6.88e-05 | 3.18e-01 | 0.1426 |
50861 | STMN3 | P12T-E | Human | Esophagus | ESCC | 7.62e-48 | 8.30e-01 | 0.1122 |
50861 | STMN3 | P16T-E | Human | Esophagus | ESCC | 4.32e-54 | 1.20e+00 | 0.1153 |
50861 | STMN3 | P19T-E | Human | Esophagus | ESCC | 1.32e-10 | 6.77e-01 | 0.1662 |
50861 | STMN3 | P20T-E | Human | Esophagus | ESCC | 3.93e-25 | 6.91e-01 | 0.1124 |
50861 | STMN3 | P21T-E | Human | Esophagus | ESCC | 1.60e-13 | 3.23e-01 | 0.1617 |
50861 | STMN3 | P22T-E | Human | Esophagus | ESCC | 1.18e-11 | 3.17e-01 | 0.1236 |
50861 | STMN3 | P23T-E | Human | Esophagus | ESCC | 2.48e-03 | 1.56e-01 | 0.108 |
50861 | STMN3 | P24T-E | Human | Esophagus | ESCC | 2.74e-14 | 3.86e-01 | 0.1287 |
50861 | STMN3 | P26T-E | Human | Esophagus | ESCC | 1.09e-14 | 3.09e-01 | 0.1276 |
50861 | STMN3 | P27T-E | Human | Esophagus | ESCC | 6.94e-05 | 1.57e-01 | 0.1055 |
50861 | STMN3 | P28T-E | Human | Esophagus | ESCC | 1.22e-04 | 1.79e-01 | 0.1149 |
50861 | STMN3 | P30T-E | Human | Esophagus | ESCC | 2.11e-03 | 3.35e-01 | 0.137 |
50861 | STMN3 | P31T-E | Human | Esophagus | ESCC | 1.96e-06 | 1.82e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00311104 | Esophagus | ESCC | regulation of microtubule polymerization or depolymerization | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
GO:0035020 | Esophagus | ESCC | regulation of Rac protein signal transduction | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STMN3 | SNV | Missense_Mutation | novel | c.494C>T | p.Ala165Val | p.A165V | Q9NZ72 | protein_coding | tolerated(0.08) | possibly_damaging(0.709) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
STMN3 | SNV | Missense_Mutation | rs556068883 | c.100N>A | p.Val34Ile | p.V34I | Q9NZ72 | protein_coding | tolerated(1) | benign(0) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
STMN3 | SNV | Missense_Mutation | c.156N>T | p.Gln52His | p.Q52H | Q9NZ72 | protein_coding | tolerated(0.05) | probably_damaging(0.965) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
STMN3 | SNV | Missense_Mutation | novel | c.488T>C | p.Leu163Pro | p.L163P | Q9NZ72 | protein_coding | tolerated(0.07) | possibly_damaging(0.5) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
STMN3 | SNV | Missense_Mutation | novel | c.352N>A | p.Leu118Met | p.L118M | Q9NZ72 | protein_coding | tolerated(0.06) | benign(0.287) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STMN3 | SNV | Missense_Mutation | c.56N>T | p.Ser19Leu | p.S19L | Q9NZ72 | protein_coding | deleterious(0.01) | benign(0.109) | TCGA-DD-A4NJ-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
STMN3 | SNV | Missense_Mutation | novel | c.347N>G | p.Glu116Gly | p.E116G | Q9NZ72 | protein_coding | deleterious(0) | benign(0.236) | TCGA-DD-AADQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STMN3 | SNV | Missense_Mutation | novel | c.162C>A | p.Phe54Leu | p.F54L | Q9NZ72 | protein_coding | tolerated(0.06) | benign(0.202) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STMN3 | SNV | Missense_Mutation | c.478G>A | p.Glu160Lys | p.E160K | Q9NZ72 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
STMN3 | SNV | Missense_Mutation | c.304N>A | p.Gln102Lys | p.Q102K | Q9NZ72 | protein_coding | deleterious(0.04) | possibly_damaging(0.478) | TCGA-22-5472-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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