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Gene: STK40 |
Gene summary for STK40 |
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Gene information | Species | Human | Gene symbol | STK40 | Gene ID | 83931 |
Gene name | serine/threonine kinase 40 | |
Gene Alias | SHIK | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q8N2I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83931 | STK40 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.19e-02 | 3.77e-01 | -0.1808 |
83931 | STK40 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.06e-03 | 3.31e-01 | -0.0811 |
83931 | STK40 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.09e-06 | 3.94e-01 | -0.1954 |
83931 | STK40 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.63e-03 | 4.44e-01 | -0.1526 |
83931 | STK40 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.14e-03 | 3.04e-01 | -0.1464 |
83931 | STK40 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.45e-03 | 3.65e-01 | -0.059 |
83931 | STK40 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.02e-04 | 5.04e-01 | 0.3859 |
83931 | STK40 | A015-C-203 | Human | Colorectum | FAP | 1.51e-05 | -1.50e-01 | -0.1294 |
83931 | STK40 | A001-C-108 | Human | Colorectum | FAP | 1.39e-02 | -1.14e-01 | -0.0272 |
83931 | STK40 | A015-C-106 | Human | Colorectum | FAP | 5.65e-04 | -1.36e-01 | -0.0511 |
83931 | STK40 | A002-C-114 | Human | Colorectum | FAP | 2.97e-02 | -1.83e-01 | -0.1561 |
83931 | STK40 | A015-C-104 | Human | Colorectum | FAP | 2.06e-08 | -1.85e-01 | -0.1899 |
83931 | STK40 | A002-C-016 | Human | Colorectum | FAP | 1.53e-04 | -1.35e-01 | 0.0521 |
83931 | STK40 | A002-C-116 | Human | Colorectum | FAP | 6.58e-09 | -1.85e-01 | -0.0452 |
83931 | STK40 | A018-E-020 | Human | Colorectum | FAP | 3.75e-02 | -1.52e-01 | -0.2034 |
83931 | STK40 | F034 | Human | Colorectum | FAP | 1.29e-05 | -1.62e-01 | -0.0665 |
83931 | STK40 | F072B | Human | Colorectum | FAP | 3.44e-03 | -1.49e-01 | 0.257 |
83931 | STK40 | LZE8T | Human | Esophagus | ESCC | 3.45e-05 | -2.20e-03 | 0.067 |
83931 | STK40 | LZE20T | Human | Esophagus | ESCC | 1.53e-05 | 2.89e-02 | 0.0662 |
83931 | STK40 | LZE22T | Human | Esophagus | ESCC | 3.00e-03 | 1.34e-01 | 0.068 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0060425 | Colorectum | AD | lung morphogenesis | 20/3918 | 50/18723 | 1.65e-03 | 1.38e-02 | 20 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00159801 | Colorectum | SER | energy derivation by oxidation of organic compounds | 119/2897 | 318/18723 | 5.28e-22 | 4.62e-19 | 119 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00159802 | Colorectum | MSS | energy derivation by oxidation of organic compounds | 131/3467 | 318/18723 | 2.60e-21 | 2.70e-18 | 131 |
GO:00604251 | Colorectum | MSS | lung morphogenesis | 20/3467 | 50/18723 | 3.25e-04 | 4.21e-03 | 20 |
GO:0035264 | Colorectum | MSS | multicellular organism growth | 37/3467 | 132/18723 | 4.77e-03 | 3.34e-02 | 37 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00159804 | Colorectum | FAP | energy derivation by oxidation of organic compounds | 85/2622 | 318/18723 | 1.36e-09 | 2.77e-07 | 85 |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00604252 | Colorectum | FAP | lung morphogenesis | 16/2622 | 50/18723 | 9.14e-04 | 9.20e-03 | 16 |
GO:00352641 | Colorectum | FAP | multicellular organism growth | 31/2622 | 132/18723 | 2.28e-03 | 1.84e-02 | 31 |
GO:0030323 | Colorectum | FAP | respiratory tube development | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0030324 | Colorectum | FAP | lung development | 38/2622 | 177/18723 | 4.28e-03 | 2.93e-02 | 38 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK40 | SNV | Missense_Mutation | rs766359218 | c.95N>T | p.Ala32Val | p.A32V | Q8N2I9 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | rs777336899 | c.563N>A | p.Arg188His | p.R188H | Q8N2I9 | protein_coding | deleterious(0.02) | possibly_damaging(0.878) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | c.757C>T | p.Arg253Trp | p.R253W | Q8N2I9 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK40 | SNV | Missense_Mutation | c.917A>T | p.Glu306Val | p.E306V | Q8N2I9 | protein_coding | tolerated(0.11) | benign(0.229) | TCGA-AF-3911-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD | |
STK40 | SNV | Missense_Mutation | rs534849916 | c.1088C>T | p.Ala363Val | p.A363V | Q8N2I9 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | novel | c.130N>A | p.Pro44Thr | p.P44T | Q8N2I9 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | c.1153C>T | p.Arg385Cys | p.R385C | Q8N2I9 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.764) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
STK40 | SNV | Missense_Mutation | novel | c.755G>A | p.Gly252Asp | p.G252D | Q8N2I9 | protein_coding | tolerated(0.08) | possibly_damaging(0.683) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | novel | c.304N>A | p.Leu102Met | p.L102M | Q8N2I9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK40 | SNV | Missense_Mutation | rs201394626 | c.41C>T | p.Ser14Leu | p.S14L | Q8N2I9 | protein_coding | tolerated_low_confidence(0.25) | benign(0.044) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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