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Gene: STK32A |
Gene summary for STK32A |
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Gene information | Species | Human | Gene symbol | STK32A | Gene ID | 202374 |
Gene name | serine/threonine kinase 32A | |
Gene Alias | YANK1 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8WU08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
202374 | STK32A | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.02e-02 | 3.76e-01 | -0.2116 |
202374 | STK32A | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 5.84e-16 | 6.29e-01 | -0.0166 |
202374 | STK32A | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.42e-18 | 6.27e-01 | -0.0132 |
202374 | STK32A | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.75e-20 | 6.14e-01 | -0.013 |
202374 | STK32A | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.40e-13 | 5.56e-01 | -0.0121 |
202374 | STK32A | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.93e-09 | 9.52e-01 | -0.0961 |
202374 | STK32A | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.01e-12 | 1.04e+00 | -0.0876 |
202374 | STK32A | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.47e-11 | 1.05e+00 | -0.0822 |
202374 | STK32A | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 7.43e-13 | 1.03e+00 | -0.0809 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00181056 | Lung | IAC | peptidyl-serine phosphorylation | 69/2061 | 315/18723 | 1.48e-08 | 1.87e-06 | 69 |
GO:00182095 | Lung | IAC | peptidyl-serine modification | 70/2061 | 338/18723 | 1.23e-07 | 1.10e-05 | 70 |
GO:001810512 | Lung | AIS | peptidyl-serine phosphorylation | 60/1849 | 315/18723 | 4.75e-07 | 3.64e-05 | 60 |
GO:001820912 | Lung | AIS | peptidyl-serine modification | 61/1849 | 338/18723 | 2.49e-06 | 1.41e-04 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK32A | SNV | Missense_Mutation | c.53T>C | p.Val18Ala | p.V18A | protein_coding | deleterious(0) | benign(0.081) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
STK32A | SNV | Missense_Mutation | rs546601610 | c.178N>A | p.Val60Met | p.V60M | protein_coding | deleterious(0.03) | benign(0.418) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK32A | SNV | Missense_Mutation | novel | c.935N>C | p.Glu312Ala | p.E312A | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK32A | SNV | Missense_Mutation | c.1039C>A | p.Leu347Ile | p.L347I | protein_coding | tolerated(0.29) | benign(0.119) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
STK32A | SNV | Missense_Mutation | c.517N>G | p.Arg173Gly | p.R173G | protein_coding | tolerated(0.41) | benign(0) | TCGA-G4-6294-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
STK32A | SNV | Missense_Mutation | novel | c.983N>C | p.Lys328Thr | p.K328T | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK32A | SNV | Missense_Mutation | rs375612505 | c.466N>A | p.Glu156Lys | p.E156K | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK32A | SNV | Missense_Mutation | rs757351674 | c.784N>A | p.Glu262Lys | p.E262K | protein_coding | tolerated(0.58) | benign(0.022) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK32A | SNV | Missense_Mutation | c.686N>A | p.Thr229Asn | p.T229N | protein_coding | tolerated(0.23) | benign(0.158) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
STK32A | SNV | Missense_Mutation | rs747788851 | c.64N>T | p.His22Tyr | p.H22Y | protein_coding | deleterious(0) | benign(0.275) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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