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Gene: STAP2 |
Gene summary for STAP2 |
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Gene information | Species | Human | Gene symbol | STAP2 | Gene ID | 55620 |
Gene name | signal transducing adaptor family member 2 | |
Gene Alias | BKS | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9UGK3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55620 | STAP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.11e-05 | 4.53e-01 | -0.1808 |
55620 | STAP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.31e-09 | 4.22e-01 | -0.1954 |
55620 | STAP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.31e-03 | 8.29e-01 | -0.2602 |
55620 | STAP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.49e-02 | 3.42e-01 | -0.1207 |
55620 | STAP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.25e-06 | 4.17e-01 | -0.1526 |
55620 | STAP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.10e-20 | 5.60e-01 | -0.1464 |
55620 | STAP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.38e-06 | 3.38e-01 | -0.1001 |
55620 | STAP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.29e-06 | 3.91e-01 | -0.059 |
55620 | STAP2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.97e-02 | 4.10e-01 | -0.0842 |
55620 | STAP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.41e-02 | 2.44e-01 | 0.0674 |
55620 | STAP2 | A015-C-203 | Human | Colorectum | FAP | 3.08e-06 | 2.27e-01 | -0.1294 |
55620 | STAP2 | A015-C-104 | Human | Colorectum | FAP | 2.20e-04 | 7.26e-02 | -0.1899 |
55620 | STAP2 | A002-C-116 | Human | Colorectum | FAP | 1.19e-02 | -6.65e-02 | -0.0452 |
55620 | STAP2 | LZE3D | Human | Esophagus | HGIN | 1.52e-02 | 4.13e-01 | 0.0668 |
55620 | STAP2 | LZE4T | Human | Esophagus | ESCC | 1.73e-06 | 4.43e-01 | 0.0811 |
55620 | STAP2 | LZE7T | Human | Esophagus | ESCC | 4.90e-05 | 6.14e-01 | 0.0667 |
55620 | STAP2 | LZE8T | Human | Esophagus | ESCC | 2.03e-10 | 4.79e-01 | 0.067 |
55620 | STAP2 | LZE20T | Human | Esophagus | ESCC | 5.95e-04 | 2.27e-01 | 0.0662 |
55620 | STAP2 | LZE22T | Human | Esophagus | ESCC | 2.43e-05 | 4.58e-01 | 0.068 |
55620 | STAP2 | LZE24T | Human | Esophagus | ESCC | 1.83e-21 | 8.86e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAP2 | SNV | Missense_Mutation | c.1241N>A | p.Arg414Lys | p.R414K | Q9UGK3 | protein_coding | tolerated_low_confidence(0.58) | benign(0.005) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
STAP2 | deletion | Frame_Shift_Del | novel | c.813delN | p.Ser272ProfsTer40 | p.S272Pfs*40 | Q9UGK3 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
STAP2 | SNV | Missense_Mutation | rs763722818 | c.163C>T | p.Arg55Trp | p.R55W | Q9UGK3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STAP2 | SNV | Missense_Mutation | rs372268872 | c.91C>T | p.Pro31Ser | p.P31S | Q9UGK3 | protein_coding | tolerated(0.34) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STAP2 | SNV | Missense_Mutation | rs746019430 | c.434N>A | p.Arg145His | p.R145H | Q9UGK3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAP2 | SNV | Missense_Mutation | c.605N>A | p.Arg202Gln | p.R202Q | Q9UGK3 | protein_coding | deleterious(0.02) | possibly_damaging(0.547) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
STAP2 | SNV | Missense_Mutation | c.458N>A | p.Cys153Tyr | p.C153Y | Q9UGK3 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
STAP2 | SNV | Missense_Mutation | c.1141N>C | p.Ser381Pro | p.S381P | Q9UGK3 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STAP2 | SNV | Missense_Mutation | rs770230350 | c.872N>T | p.Ala291Val | p.A291V | Q9UGK3 | protein_coding | tolerated(1) | benign(0.001) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAP2 | SNV | Missense_Mutation | novel | c.700N>A | p.Val234Met | p.V234M | Q9UGK3 | protein_coding | deleterious(0.05) | possibly_damaging(0.88) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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