|
Gene: SSR4 |
Gene summary for SSR4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SSR4 | Gene ID | 6748 |
Gene name | signal sequence receptor subunit 4 | |
Gene Alias | CDG1Y | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P51571 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6748 | SSR4 | GSM4909277 | Human | Breast | Precancer | 6.13e-05 | -8.60e-01 | 0.0177 |
6748 | SSR4 | GSM4909280 | Human | Breast | Precancer | 4.00e-05 | -7.10e-01 | 0.0305 |
6748 | SSR4 | GSM4909282 | Human | Breast | IDC | 4.69e-06 | 2.55e-01 | -0.0288 |
6748 | SSR4 | GSM4909287 | Human | Breast | IDC | 5.69e-30 | 4.42e-01 | 0.2057 |
6748 | SSR4 | GSM4909288 | Human | Breast | IDC | 4.10e-05 | -2.39e-02 | 0.0988 |
6748 | SSR4 | GSM4909290 | Human | Breast | IDC | 9.51e-06 | 3.14e-01 | 0.2096 |
6748 | SSR4 | GSM4909293 | Human | Breast | IDC | 4.09e-07 | -2.48e-01 | 0.1581 |
6748 | SSR4 | GSM4909294 | Human | Breast | IDC | 5.10e-18 | -4.79e-02 | 0.2022 |
6748 | SSR4 | GSM4909296 | Human | Breast | IDC | 4.20e-23 | 1.21e-01 | 0.1524 |
6748 | SSR4 | GSM4909297 | Human | Breast | IDC | 3.86e-37 | -2.68e-01 | 0.1517 |
6748 | SSR4 | GSM4909298 | Human | Breast | IDC | 3.12e-15 | -4.14e-01 | 0.1551 |
6748 | SSR4 | GSM4909301 | Human | Breast | IDC | 3.70e-09 | 1.77e-01 | 0.1577 |
6748 | SSR4 | GSM4909302 | Human | Breast | IDC | 5.86e-14 | 2.53e-01 | 0.1545 |
6748 | SSR4 | GSM4909304 | Human | Breast | IDC | 7.74e-20 | 3.94e-01 | 0.1636 |
6748 | SSR4 | GSM4909306 | Human | Breast | IDC | 8.06e-05 | 2.52e-01 | 0.1564 |
6748 | SSR4 | GSM4909307 | Human | Breast | IDC | 1.56e-06 | 2.07e-01 | 0.1569 |
6748 | SSR4 | GSM4909308 | Human | Breast | IDC | 1.21e-10 | 3.78e-01 | 0.158 |
6748 | SSR4 | GSM4909309 | Human | Breast | IDC | 1.16e-03 | -1.28e-01 | 0.0483 |
6748 | SSR4 | GSM4909311 | Human | Breast | IDC | 2.86e-68 | -2.67e-01 | 0.1534 |
6748 | SSR4 | GSM4909312 | Human | Breast | IDC | 1.30e-18 | -1.42e-01 | 0.1552 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414144 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0414154 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSR4 | SNV | Missense_Mutation | c.287G>A | p.Ser96Asn | p.S96N | P51571 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SSR4 | SNV | Missense_Mutation | novel | c.116N>A | p.Ser39Tyr | p.S39Y | P51571 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSR4 | SNV | Missense_Mutation | novel | c.400N>T | p.Val134Phe | p.V134F | P51571 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SSR4 | SNV | Missense_Mutation | novel | c.236N>A | p.Arg79Gln | p.R79Q | P51571 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSR4 | SNV | Missense_Mutation | rs149873632 | c.208N>A | p.Val70Ile | p.V70I | P51571 | protein_coding | tolerated(0.14) | benign(0.32) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SSR4 | SNV | Missense_Mutation | c.238N>T | p.Gly80Cys | p.G80C | P51571 | protein_coding | tolerated(0.07) | probably_damaging(0.983) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SSR4 | SNV | Missense_Mutation | novel | c.490N>T | p.Ala164Ser | p.A164S | P51571 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSR4 | SNV | Missense_Mutation | c.19N>G | p.Leu7Val | p.L7V | P51571 | protein_coding | tolerated(1) | possibly_damaging(0.458) | TCGA-55-6642-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SSR4 | SNV | Missense_Mutation | c.208N>T | p.Val70Phe | p.V70F | P51571 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-93-7347-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSR4 | SNV | Missense_Mutation | rs782282879 | c.322N>A | p.Asp108Asn | p.D108N | P51571 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CQ-6228-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |