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Gene: SRSF11 |
Gene summary for SRSF11 |
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Gene information | Species | Human | Gene symbol | SRSF11 | Gene ID | 9295 |
Gene name | serine and arginine rich splicing factor 11 | |
Gene Alias | NET2 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05519 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9295 | SRSF11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.74e-30 | -7.79e-01 | 0.0155 |
9295 | SRSF11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.21e-04 | -4.51e-01 | -0.1808 |
9295 | SRSF11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.17e-14 | -7.72e-01 | -0.1207 |
9295 | SRSF11 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.64e-14 | -5.08e-01 | -0.1464 |
9295 | SRSF11 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.66e-06 | -3.69e-01 | -0.1001 |
9295 | SRSF11 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.12e-05 | -6.90e-01 | -0.2061 |
9295 | SRSF11 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.32e-03 | -4.02e-01 | 0.096 |
9295 | SRSF11 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.89e-03 | -6.71e-01 | 0.0446 |
9295 | SRSF11 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.57e-02 | -6.02e-01 | 0.0528 |
9295 | SRSF11 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.02e-08 | -6.05e-01 | 0.0338 |
9295 | SRSF11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.11e-04 | -3.28e-01 | 0.0674 |
9295 | SRSF11 | HTA11_11156_2000001011 | Human | Colorectum | AD | 8.42e-03 | -9.25e-01 | 0.0397 |
9295 | SRSF11 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.13e-02 | -4.81e-01 | 0.0588 |
9295 | SRSF11 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.89e-02 | -5.05e-01 | 0.2585 |
9295 | SRSF11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.91e-12 | -4.14e-01 | 0.3005 |
9295 | SRSF11 | A002-C-010 | Human | Colorectum | FAP | 4.23e-04 | -2.22e-01 | 0.242 |
9295 | SRSF11 | A001-C-207 | Human | Colorectum | FAP | 1.01e-02 | -2.16e-01 | 0.1278 |
9295 | SRSF11 | A015-C-203 | Human | Colorectum | FAP | 1.36e-34 | 9.27e-03 | -0.1294 |
9295 | SRSF11 | A015-C-204 | Human | Colorectum | FAP | 3.94e-05 | -1.66e-01 | -0.0228 |
9295 | SRSF11 | A014-C-040 | Human | Colorectum | FAP | 1.08e-04 | -1.88e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:000838017 | Endometrium | EEC | RNA splicing | 111/2168 | 434/18723 | 2.45e-16 | 1.13e-13 | 111 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:00083808 | Lung | IAC | RNA splicing | 75/2061 | 434/18723 | 4.89e-05 | 1.12e-03 | 75 |
GO:000838013 | Lung | AIS | RNA splicing | 68/1849 | 434/18723 | 8.50e-05 | 2.11e-03 | 68 |
GO:000838023 | Lung | MIAC | RNA splicing | 44/967 | 434/18723 | 1.56e-05 | 1.07e-03 | 44 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:000838025 | Oral cavity | EOLP | RNA splicing | 115/2218 | 434/18723 | 2.24e-17 | 3.04e-14 | 115 |
GO:000838033 | Oral cavity | NEOLP | RNA splicing | 110/2005 | 434/18723 | 2.29e-18 | 2.72e-15 | 110 |
GO:000838018 | Prostate | BPH | RNA splicing | 147/3107 | 434/18723 | 5.17e-19 | 2.29e-16 | 147 |
GO:000838019 | Prostate | Tumor | RNA splicing | 153/3246 | 434/18723 | 9.15e-20 | 5.79e-17 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRSF11 | SNV | Missense_Mutation | novel | c.479C>G | p.Ala160Gly | p.A160G | Q05519 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SRSF11 | SNV | Missense_Mutation | c.635C>T | p.Ser212Leu | p.S212L | Q05519 | protein_coding | tolerated(0.09) | benign(0.026) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SRSF11 | SNV | Missense_Mutation | c.964C>T | p.Arg322Cys | p.R322C | Q05519 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
SRSF11 | SNV | Missense_Mutation | novel | c.874N>T | p.Arg292Trp | p.R292W | Q05519 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
SRSF11 | insertion | Frame_Shift_Ins | novel | c.1070dupA | p.Pro358AlafsTer5 | p.P358Afs*5 | Q05519 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SRSF11 | SNV | Missense_Mutation | c.637G>A | p.Asp213Asn | p.D213N | Q05519 | protein_coding | tolerated(0.17) | probably_damaging(0.989) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SRSF11 | SNV | Missense_Mutation | c.1330N>T | p.Pro444Ser | p.P444S | Q05519 | protein_coding | tolerated_low_confidence(1) | benign(0.177) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRSF11 | SNV | Missense_Mutation | c.1031N>A | p.Arg344Gln | p.R344Q | Q05519 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SRSF11 | SNV | Missense_Mutation | c.685G>A | p.Ala229Thr | p.A229T | Q05519 | protein_coding | tolerated(0.06) | probably_damaging(0.989) | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD | |
SRSF11 | SNV | Missense_Mutation | c.823C>T | p.Arg275Trp | p.R275W | Q05519 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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