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Gene: SREK1IP1 |
Gene summary for SREK1IP1 |
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Gene information | Species | Human | Gene symbol | SREK1IP1 | Gene ID | 285672 |
Gene name | SREK1 interacting protein 1 | |
Gene Alias | P18SRP | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N9Q2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285672 | SREK1IP1 | LZE4T | Human | Esophagus | ESCC | 1.42e-05 | 1.63e-01 | 0.0811 |
285672 | SREK1IP1 | LZE5T | Human | Esophagus | ESCC | 1.22e-02 | -6.18e-03 | 0.0514 |
285672 | SREK1IP1 | LZE7T | Human | Esophagus | ESCC | 1.22e-03 | 3.60e-01 | 0.0667 |
285672 | SREK1IP1 | LZE8T | Human | Esophagus | ESCC | 9.84e-04 | -2.41e-04 | 0.067 |
285672 | SREK1IP1 | LZE20T | Human | Esophagus | ESCC | 6.04e-07 | 1.32e-01 | 0.0662 |
285672 | SREK1IP1 | LZE22D1 | Human | Esophagus | HGIN | 6.47e-07 | -3.05e-02 | 0.0595 |
285672 | SREK1IP1 | LZE22T | Human | Esophagus | ESCC | 4.66e-04 | -3.48e-02 | 0.068 |
285672 | SREK1IP1 | LZE24T | Human | Esophagus | ESCC | 2.84e-11 | 1.64e-01 | 0.0596 |
285672 | SREK1IP1 | LZE6T | Human | Esophagus | ESCC | 8.44e-06 | 1.91e-01 | 0.0845 |
285672 | SREK1IP1 | P1T-E | Human | Esophagus | ESCC | 1.93e-10 | 7.46e-01 | 0.0875 |
285672 | SREK1IP1 | P2T-E | Human | Esophagus | ESCC | 4.42e-17 | 3.88e-01 | 0.1177 |
285672 | SREK1IP1 | P4T-E | Human | Esophagus | ESCC | 7.96e-11 | 3.14e-01 | 0.1323 |
285672 | SREK1IP1 | P5T-E | Human | Esophagus | ESCC | 2.73e-14 | 2.64e-01 | 0.1327 |
285672 | SREK1IP1 | P8T-E | Human | Esophagus | ESCC | 2.99e-31 | 5.03e-01 | 0.0889 |
285672 | SREK1IP1 | P9T-E | Human | Esophagus | ESCC | 1.42e-16 | 4.88e-01 | 0.1131 |
285672 | SREK1IP1 | P10T-E | Human | Esophagus | ESCC | 4.88e-24 | 3.15e-01 | 0.116 |
285672 | SREK1IP1 | P11T-E | Human | Esophagus | ESCC | 4.17e-11 | 6.96e-01 | 0.1426 |
285672 | SREK1IP1 | P12T-E | Human | Esophagus | ESCC | 9.22e-22 | 4.85e-01 | 0.1122 |
285672 | SREK1IP1 | P15T-E | Human | Esophagus | ESCC | 8.44e-14 | 2.08e-01 | 0.1149 |
285672 | SREK1IP1 | P16T-E | Human | Esophagus | ESCC | 2.23e-16 | 1.54e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:000838027 | Skin | AK | RNA splicing | 111/1910 | 434/18723 | 1.85e-20 | 5.49e-17 | 111 |
GO:0008380112 | Skin | cSCC | RNA splicing | 263/4864 | 434/18723 | 2.45e-53 | 5.13e-50 | 263 |
GO:000838028 | Thyroid | HT | RNA splicing | 84/1272 | 434/18723 | 1.23e-18 | 1.14e-15 | 84 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:000838034 | Thyroid | ATC | RNA splicing | 270/6293 | 434/18723 | 7.50e-35 | 1.19e-31 | 270 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SREK1IP1 | deletion | Frame_Shift_Del | rs758194195 | c.271delA | p.Arg91GlyfsTer67 | p.R91Gfs*67 | Q8N9Q2 | protein_coding | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SREK1IP1 | insertion | Frame_Shift_Ins | novel | c.381_382insA | p.Gly128ArgfsTer21 | p.G128Rfs*21 | Q8N9Q2 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SREK1IP1 | deletion | Frame_Shift_Del | c.381delN | p.Lys129AsnfsTer29 | p.K129Nfs*29 | Q8N9Q2 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
SREK1IP1 | deletion | Frame_Shift_Del | rs758194195 | c.271delN | p.Arg91GlyfsTer67 | p.R91Gfs*67 | Q8N9Q2 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
SREK1IP1 | insertion | Frame_Shift_Ins | novel | c.407_408insA | p.Lys137GlufsTer12 | p.K137Efs*12 | Q8N9Q2 | protein_coding | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | ||
SREK1IP1 | deletion | Frame_Shift_Del | rs772485731 | c.407delA | p.Lys136ArgfsTer22 | p.K136Rfs*22 | Q8N9Q2 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SREK1IP1 | SNV | Missense_Mutation | novel | c.14N>A | p.Gly5Asp | p.G5D | Q8N9Q2 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SREK1IP1 | SNV | Missense_Mutation | novel | c.456C>A | p.Phe152Leu | p.F152L | Q8N9Q2 | protein_coding | tolerated_low_confidence(0.05) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SREK1IP1 | SNV | Missense_Mutation | c.446G>T | p.Ser149Ile | p.S149I | Q8N9Q2 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SREK1IP1 | SNV | Missense_Mutation | c.405A>C | p.Lys135Asn | p.K135N | Q8N9Q2 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.913) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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