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Gene: SPNS1 |
Gene summary for SPNS1 |
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Gene information | Species | Human | Gene symbol | SPNS1 | Gene ID | 83985 |
Gene name | sphingolipid transporter 1 (putative) | |
Gene Alias | HSpin1 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H2V7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83985 | SPNS1 | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.66e-01 | 0.082 |
83985 | SPNS1 | LZE4T | Human | Esophagus | ESCC | 6.19e-10 | 2.80e-01 | 0.0811 |
83985 | SPNS1 | LZE5T | Human | Esophagus | ESCC | 1.40e-06 | 3.36e-01 | 0.0514 |
83985 | SPNS1 | LZE7T | Human | Esophagus | ESCC | 4.33e-11 | 5.21e-01 | 0.0667 |
83985 | SPNS1 | LZE8T | Human | Esophagus | ESCC | 1.35e-07 | 2.65e-01 | 0.067 |
83985 | SPNS1 | LZE20T | Human | Esophagus | ESCC | 1.30e-10 | 3.51e-01 | 0.0662 |
83985 | SPNS1 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 3.94e-01 | 0.0632 |
83985 | SPNS1 | LZE22D1 | Human | Esophagus | HGIN | 8.03e-04 | 2.01e-01 | 0.0595 |
83985 | SPNS1 | LZE22T | Human | Esophagus | ESCC | 1.15e-08 | 5.38e-01 | 0.068 |
83985 | SPNS1 | LZE24T | Human | Esophagus | ESCC | 5.96e-45 | 1.12e+00 | 0.0596 |
83985 | SPNS1 | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 3.66e-01 | 0.0655 |
83985 | SPNS1 | LZE6T | Human | Esophagus | ESCC | 2.96e-03 | 1.56e-01 | 0.0845 |
83985 | SPNS1 | P1T-E | Human | Esophagus | ESCC | 1.23e-18 | 7.63e-01 | 0.0875 |
83985 | SPNS1 | P2T-E | Human | Esophagus | ESCC | 1.03e-89 | 1.26e+00 | 0.1177 |
83985 | SPNS1 | P4T-E | Human | Esophagus | ESCC | 9.78e-64 | 1.31e+00 | 0.1323 |
83985 | SPNS1 | P5T-E | Human | Esophagus | ESCC | 5.17e-27 | 4.46e-01 | 0.1327 |
83985 | SPNS1 | P8T-E | Human | Esophagus | ESCC | 6.89e-44 | 6.83e-01 | 0.0889 |
83985 | SPNS1 | P9T-E | Human | Esophagus | ESCC | 1.37e-15 | 3.26e-01 | 0.1131 |
83985 | SPNS1 | P10T-E | Human | Esophagus | ESCC | 1.35e-23 | 3.87e-01 | 0.116 |
83985 | SPNS1 | P11T-E | Human | Esophagus | ESCC | 2.64e-31 | 1.09e+00 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPNS1 | SNV | Missense_Mutation | c.1026N>C | p.Glu342Asp | p.E342D | Q9H2V7 | protein_coding | tolerated(0.07) | possibly_damaging(0.763) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SPNS1 | SNV | Missense_Mutation | rs768596902 | c.1018N>T | p.Gly340Cys | p.G340C | Q9H2V7 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SPNS1 | SNV | Missense_Mutation | rs781243388 | c.1522G>A | p.Asp508Asn | p.D508N | Q9H2V7 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
SPNS1 | SNV | Missense_Mutation | rs750776330 | c.1340N>A | p.Arg447Gln | p.R447Q | Q9H2V7 | protein_coding | tolerated(0.65) | benign(0.011) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
SPNS1 | SNV | Missense_Mutation | rs201744028 | c.1504N>A | p.Glu502Lys | p.E502K | Q9H2V7 | protein_coding | tolerated(0.68) | benign(0.005) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPNS1 | SNV | Missense_Mutation | rs773924844 | c.1133N>A | p.Arg378His | p.R378H | Q9H2V7 | protein_coding | tolerated(0.05) | benign(0.026) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPNS1 | SNV | Missense_Mutation | c.703N>C | p.Phe235Leu | p.F235L | Q9H2V7 | protein_coding | tolerated(0.66) | benign(0.006) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPNS1 | SNV | Missense_Mutation | c.905G>A | p.Arg302His | p.R302H | Q9H2V7 | protein_coding | tolerated(0.12) | benign(0.125) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SPNS1 | SNV | Missense_Mutation | rs759504146 | c.736N>A | p.Val246Met | p.V246M | Q9H2V7 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SPNS1 | SNV | Missense_Mutation | novel | c.388N>A | p.Gly130Arg | p.G130R | Q9H2V7 | protein_coding | tolerated(0.35) | possibly_damaging(0.734) | TCGA-5B-A90C-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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