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Gene: SPAG16 |
Gene summary for SPAG16 |
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Gene information | Species | Human | Gene symbol | SPAG16 | Gene ID | 79582 |
Gene name | sperm associated antigen 16 | |
Gene Alias | PF20 | |
Cytomap | 2q34 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q4G1A2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79582 | SPAG16 | LZE2T | Human | Esophagus | ESCC | 4.27e-02 | 3.86e-01 | 0.082 |
79582 | SPAG16 | LZE4T | Human | Esophagus | ESCC | 2.71e-08 | 2.16e-01 | 0.0811 |
79582 | SPAG16 | LZE8T | Human | Esophagus | ESCC | 6.02e-05 | 1.88e-01 | 0.067 |
79582 | SPAG16 | LZE20T | Human | Esophagus | ESCC | 3.56e-02 | 5.79e-02 | 0.0662 |
79582 | SPAG16 | LZE24T | Human | Esophagus | ESCC | 1.67e-19 | 7.61e-01 | 0.0596 |
79582 | SPAG16 | LZE6T | Human | Esophagus | ESCC | 1.43e-03 | 1.53e-01 | 0.0845 |
79582 | SPAG16 | P1T-E | Human | Esophagus | ESCC | 9.66e-07 | 1.85e-01 | 0.0875 |
79582 | SPAG16 | P2T-E | Human | Esophagus | ESCC | 1.06e-38 | 6.66e-01 | 0.1177 |
79582 | SPAG16 | P4T-E | Human | Esophagus | ESCC | 1.57e-13 | 2.47e-01 | 0.1323 |
79582 | SPAG16 | P5T-E | Human | Esophagus | ESCC | 3.58e-08 | 1.51e-01 | 0.1327 |
79582 | SPAG16 | P8T-E | Human | Esophagus | ESCC | 1.34e-44 | 6.95e-01 | 0.0889 |
79582 | SPAG16 | P9T-E | Human | Esophagus | ESCC | 1.82e-05 | 1.38e-02 | 0.1131 |
79582 | SPAG16 | P10T-E | Human | Esophagus | ESCC | 3.96e-23 | 3.19e-01 | 0.116 |
79582 | SPAG16 | P11T-E | Human | Esophagus | ESCC | 2.59e-09 | 4.68e-01 | 0.1426 |
79582 | SPAG16 | P12T-E | Human | Esophagus | ESCC | 2.34e-38 | 6.60e-01 | 0.1122 |
79582 | SPAG16 | P15T-E | Human | Esophagus | ESCC | 1.39e-21 | 4.54e-01 | 0.1149 |
79582 | SPAG16 | P16T-E | Human | Esophagus | ESCC | 3.93e-34 | 5.47e-01 | 0.1153 |
79582 | SPAG16 | P17T-E | Human | Esophagus | ESCC | 7.12e-06 | 3.14e-01 | 0.1278 |
79582 | SPAG16 | P20T-E | Human | Esophagus | ESCC | 2.64e-05 | 5.18e-03 | 0.1124 |
79582 | SPAG16 | P21T-E | Human | Esophagus | ESCC | 6.36e-03 | 2.52e-02 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:00991115 | Thyroid | PTC | microtubule-based transport | 88/5968 | 190/18723 | 2.08e-05 | 2.08e-04 | 88 |
GO:009911112 | Thyroid | ATC | microtubule-based transport | 91/6293 | 190/18723 | 2.97e-05 | 2.48e-04 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPAG16 | SNV | Missense_Mutation | c.1492N>A | p.Ala498Thr | p.A498T | Q8N0X2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPAG16 | SNV | Missense_Mutation | c.797N>G | p.Gln266Arg | p.Q266R | Q8N0X2 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPAG16 | SNV | Missense_Mutation | rs747474099 | c.1312N>A | p.Ala438Thr | p.A438T | Q8N0X2 | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-AG-3883-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPAG16 | SNV | Missense_Mutation | c.540A>C | p.Lys180Asn | p.K180N | Q8N0X2 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPAG16 | SNV | Missense_Mutation | c.335N>G | p.Phe112Cys | p.F112C | Q8N0X2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
SPAG16 | SNV | Missense_Mutation | rs752778146 | c.845N>A | p.Arg282His | p.R282H | Q8N0X2 | protein_coding | tolerated(0.27) | benign(0.009) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPAG16 | SNV | Missense_Mutation | c.627A>C | p.Leu209Phe | p.L209F | Q8N0X2 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-EI-6885-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | PD | |
SPAG16 | SNV | Missense_Mutation | c.337C>A | p.Leu113Ile | p.L113I | Q8N0X2 | protein_coding | tolerated(0.47) | probably_damaging(0.978) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
SPAG16 | insertion | Frame_Shift_Ins | novel | c.496_497insGGGTTTATATC | p.Asn166ArgfsTer6 | p.N166Rfs*6 | Q8N0X2 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SPAG16 | SNV | Missense_Mutation | c.674N>A | p.Pro225Gln | p.P225Q | Q8N0X2 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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