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Gene: SOX5 |
Gene summary for SOX5 |
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Gene information | Species | Human | Gene symbol | SOX5 | Gene ID | 6660 |
Gene name | SRY-box transcription factor 5 | |
Gene Alias | L-SOX5 | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P35711 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6660 | SOX5 | AEH-subject1 | Human | Endometrium | AEH | 1.03e-97 | 1.54e+00 | -0.3059 |
6660 | SOX5 | AEH-subject2 | Human | Endometrium | AEH | 2.20e-46 | 1.21e+00 | -0.2525 |
6660 | SOX5 | AEH-subject3 | Human | Endometrium | AEH | 1.41e-84 | 1.46e+00 | -0.2576 |
6660 | SOX5 | AEH-subject4 | Human | Endometrium | AEH | 1.69e-52 | 1.31e+00 | -0.2657 |
6660 | SOX5 | AEH-subject5 | Human | Endometrium | AEH | 7.87e-42 | 1.04e+00 | -0.2953 |
6660 | SOX5 | EEC-subject1 | Human | Endometrium | EEC | 7.77e-84 | 1.42e+00 | -0.2682 |
6660 | SOX5 | EEC-subject2 | Human | Endometrium | EEC | 1.74e-71 | 1.34e+00 | -0.2607 |
6660 | SOX5 | EEC-subject3 | Human | Endometrium | EEC | 1.54e-05 | 3.23e-01 | -0.2525 |
6660 | SOX5 | EEC-subject4 | Human | Endometrium | EEC | 5.09e-38 | 9.85e-01 | -0.2571 |
6660 | SOX5 | EEC-subject5 | Human | Endometrium | EEC | 7.80e-19 | 6.35e-01 | -0.249 |
6660 | SOX5 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 7.00e-03 | -3.35e-02 | -0.1869 |
6660 | SOX5 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.26e-04 | -7.45e-03 | -0.1917 |
6660 | SOX5 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.03e-05 | -6.09e-02 | -0.1916 |
6660 | SOX5 | NAFLD1 | Human | Liver | NAFLD | 6.52e-17 | 1.57e+00 | -0.04 |
6660 | SOX5 | S41 | Human | Liver | Cirrhotic | 3.22e-09 | 1.05e+00 | -0.0343 |
6660 | SOX5 | HCC1_Meng | Human | Liver | HCC | 2.08e-83 | -3.79e-01 | 0.0246 |
6660 | SOX5 | HCC2_Meng | Human | Liver | HCC | 6.90e-13 | -4.94e-01 | 0.0107 |
6660 | SOX5 | cirrhotic1 | Human | Liver | Cirrhotic | 2.00e-11 | -4.84e-01 | 0.0202 |
6660 | SOX5 | cirrhotic2 | Human | Liver | Cirrhotic | 7.07e-13 | -4.92e-01 | 0.0201 |
6660 | SOX5 | cirrhotic3 | Human | Liver | Cirrhotic | 8.33e-08 | -4.82e-01 | 0.0215 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715596 | Endometrium | AEH | response to transforming growth factor beta | 53/2100 | 256/18723 | 7.01e-06 | 1.69e-04 | 53 |
GO:00715606 | Endometrium | AEH | cellular response to transforming growth factor beta stimulus | 51/2100 | 250/18723 | 1.59e-05 | 3.32e-04 | 51 |
GO:00488635 | Endometrium | AEH | stem cell differentiation | 40/2100 | 206/18723 | 3.67e-04 | 3.99e-03 | 40 |
GO:0061448 | Endometrium | AEH | connective tissue development | 44/2100 | 252/18723 | 1.92e-03 | 1.51e-02 | 44 |
GO:007155914 | Endometrium | EEC | response to transforming growth factor beta | 54/2168 | 256/18723 | 8.25e-06 | 1.83e-04 | 54 |
GO:007156014 | Endometrium | EEC | cellular response to transforming growth factor beta stimulus | 52/2168 | 250/18723 | 1.81e-05 | 3.41e-04 | 52 |
GO:004886314 | Endometrium | EEC | stem cell differentiation | 43/2168 | 206/18723 | 8.48e-05 | 1.21e-03 | 43 |
GO:00613511 | Endometrium | EEC | neural precursor cell proliferation | 29/2168 | 145/18723 | 2.24e-03 | 1.67e-02 | 29 |
GO:00614481 | Endometrium | EEC | connective tissue development | 44/2168 | 252/18723 | 3.51e-03 | 2.36e-02 | 44 |
GO:00715593 | Liver | NAFLD | response to transforming growth factor beta | 51/1882 | 256/18723 | 1.43e-06 | 6.58e-05 | 51 |
GO:00715603 | Liver | NAFLD | cellular response to transforming growth factor beta stimulus | 48/1882 | 250/18723 | 8.27e-06 | 2.76e-04 | 48 |
GO:2000736 | Liver | NAFLD | regulation of stem cell differentiation | 14/1882 | 58/18723 | 1.48e-03 | 1.64e-02 | 14 |
GO:00488632 | Liver | NAFLD | stem cell differentiation | 33/1882 | 206/18723 | 4.81e-03 | 3.81e-02 | 33 |
GO:007155911 | Liver | Cirrhotic | response to transforming growth factor beta | 96/4634 | 256/18723 | 3.55e-06 | 6.09e-05 | 96 |
GO:007156011 | Liver | Cirrhotic | cellular response to transforming growth factor beta stimulus | 93/4634 | 250/18723 | 7.34e-06 | 1.13e-04 | 93 |
GO:20007361 | Liver | Cirrhotic | regulation of stem cell differentiation | 26/4634 | 58/18723 | 6.65e-04 | 5.04e-03 | 26 |
GO:0072497 | Liver | Cirrhotic | mesenchymal stem cell differentiation | 7/4634 | 11/18723 | 7.11e-03 | 3.41e-02 | 7 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:007155921 | Liver | HCC | response to transforming growth factor beta | 141/7958 | 256/18723 | 3.08e-05 | 3.16e-04 | 141 |
GO:007156021 | Liver | HCC | cellular response to transforming growth factor beta stimulus | 137/7958 | 250/18723 | 5.47e-05 | 5.14e-04 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX5 | SNV | Missense_Mutation | c.1957N>T | p.Arg653Trp | p.R653W | P35711 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SOX5 | SNV | Missense_Mutation | c.353G>A | p.Arg118Gln | p.R118Q | P35711 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-MU-A5YI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
SOX5 | SNV | Missense_Mutation | novel | c.851N>T | p.Pro284Leu | p.P284L | P35711 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SOX5 | SNV | Missense_Mutation | rs759171095 | c.545C>T | p.Ser182Leu | p.S182L | P35711 | protein_coding | deleterious(0.03) | benign(0.327) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SOX5 | insertion | Frame_Shift_Ins | novel | c.2173_2174insGGAATCTTCACAAGGAAAAACAAAAAATATCTAC | p.Glu725GlyfsTer24 | p.E725Gfs*24 | P35711 | protein_coding | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | ||
SOX5 | SNV | Missense_Mutation | c.2027N>C | p.Val676Ala | p.V676A | P35711 | protein_coding | deleterious(0.04) | probably_damaging(0.93) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SOX5 | SNV | Missense_Mutation | c.428N>C | p.Val143Ala | p.V143A | P35711 | protein_coding | tolerated(0.17) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SOX5 | SNV | Missense_Mutation | novel | c.1838N>T | p.Ser613Ile | p.S613I | P35711 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SOX5 | SNV | Missense_Mutation | c.1948N>T | p.Arg650Cys | p.R650C | P35711 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SOX5 | SNV | Missense_Mutation | novel | c.1827N>C | p.Gln609His | p.Q609H | P35711 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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