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Gene: SOX13 |
Gene summary for SOX13 |
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Gene information | Species | Human | Gene symbol | SOX13 | Gene ID | 9580 |
Gene name | SRY-box transcription factor 13 | |
Gene Alias | ICA12 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9UN79 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9580 | SOX13 | CCI_1 | Human | Cervix | CC | 1.40e-10 | 8.57e-01 | 0.528 |
9580 | SOX13 | CCI_3 | Human | Cervix | CC | 2.33e-04 | 5.73e-01 | 0.516 |
9580 | SOX13 | LZE2T | Human | Esophagus | ESCC | 1.11e-02 | 3.85e-01 | 0.082 |
9580 | SOX13 | LZE22T | Human | Esophagus | ESCC | 1.77e-03 | 2.21e-01 | 0.068 |
9580 | SOX13 | LZE21T | Human | Esophagus | ESCC | 8.05e-05 | 2.23e-01 | 0.0655 |
9580 | SOX13 | P2T-E | Human | Esophagus | ESCC | 7.63e-03 | 5.72e-02 | 0.1177 |
9580 | SOX13 | P4T-E | Human | Esophagus | ESCC | 6.13e-08 | 1.60e-01 | 0.1323 |
9580 | SOX13 | P5T-E | Human | Esophagus | ESCC | 1.72e-06 | 8.98e-02 | 0.1327 |
9580 | SOX13 | P8T-E | Human | Esophagus | ESCC | 4.27e-04 | 8.70e-02 | 0.0889 |
9580 | SOX13 | P9T-E | Human | Esophagus | ESCC | 5.99e-14 | 3.49e-01 | 0.1131 |
9580 | SOX13 | P10T-E | Human | Esophagus | ESCC | 2.53e-21 | 4.11e-01 | 0.116 |
9580 | SOX13 | P11T-E | Human | Esophagus | ESCC | 3.31e-02 | 1.62e-01 | 0.1426 |
9580 | SOX13 | P12T-E | Human | Esophagus | ESCC | 8.94e-07 | 1.08e-01 | 0.1122 |
9580 | SOX13 | P15T-E | Human | Esophagus | ESCC | 4.19e-12 | 1.89e-01 | 0.1149 |
9580 | SOX13 | P16T-E | Human | Esophagus | ESCC | 3.33e-12 | 1.86e-01 | 0.1153 |
9580 | SOX13 | P17T-E | Human | Esophagus | ESCC | 1.86e-03 | 1.44e-01 | 0.1278 |
9580 | SOX13 | P23T-E | Human | Esophagus | ESCC | 2.59e-07 | 1.98e-01 | 0.108 |
9580 | SOX13 | P26T-E | Human | Esophagus | ESCC | 1.63e-07 | 1.08e-01 | 0.1276 |
9580 | SOX13 | P27T-E | Human | Esophagus | ESCC | 4.59e-16 | 1.42e-01 | 0.1055 |
9580 | SOX13 | P28T-E | Human | Esophagus | ESCC | 9.86e-33 | 5.75e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:19021056 | Cervix | CC | regulation of leukocyte differentiation | 61/2311 | 279/18723 | 5.16e-06 | 1.29e-04 | 61 |
GO:00224099 | Cervix | CC | positive regulation of cell-cell adhesion | 61/2311 | 284/18723 | 9.30e-06 | 2.11e-04 | 61 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:00508708 | Cervix | CC | positive regulation of T cell activation | 49/2311 | 216/18723 | 1.51e-05 | 2.97e-04 | 49 |
GO:0045580 | Cervix | CC | regulation of T cell differentiation | 33/2311 | 146/18723 | 3.75e-04 | 3.87e-03 | 33 |
GO:00302173 | Cervix | CC | T cell differentiation | 51/2311 | 257/18723 | 3.81e-04 | 3.89e-03 | 51 |
GO:19031314 | Cervix | CC | mononuclear cell differentiation | 76/2311 | 426/18723 | 5.66e-04 | 5.42e-03 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX13 | deletion | Frame_Shift_Del | c.809delC | p.Pro270LeufsTer5 | p.P270Lfs*5 | Q9UN79 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SOX13 | SNV | Missense_Mutation | c.715N>G | p.Leu239Val | p.L239V | Q9UN79 | protein_coding | deleterious(0) | benign(0.097) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SOX13 | SNV | Missense_Mutation | c.1711N>G | p.Met571Val | p.M571V | Q9UN79 | protein_coding | deleterious(0.01) | benign(0.035) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SOX13 | SNV | Missense_Mutation | c.287C>T | p.Ser96Phe | p.S96F | Q9UN79 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SOX13 | SNV | Missense_Mutation | rs377320241 | c.533C>T | p.Ala178Val | p.A178V | Q9UN79 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SOX13 | SNV | Missense_Mutation | c.1838G>T | p.Ser613Ile | p.S613I | Q9UN79 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SOX13 | SNV | Missense_Mutation | rs377320241 | c.533C>T | p.Ala178Val | p.A178V | Q9UN79 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
SOX13 | SNV | Missense_Mutation | c.529G>A | p.Ala177Thr | p.A177T | Q9UN79 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
SOX13 | SNV | Missense_Mutation | c.1573C>T | p.Arg525Cys | p.R525C | Q9UN79 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
SOX13 | SNV | Missense_Mutation | c.1463N>G | p.Tyr488Cys | p.Y488C | Q9UN79 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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