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Gene: SNRPN |
Gene summary for SNRPN |
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Gene information | Species | Human | Gene symbol | SNRPN | Gene ID | 6638 |
Gene name | small nuclear ribonucleoprotein polypeptide N | |
Gene Alias | HCERN3 | |
Cytomap | 15q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P63162 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6638 | SNRPN | LZE3D | Human | Esophagus | HGIN | 4.10e-02 | 5.71e-01 | 0.0668 |
6638 | SNRPN | LZE4T | Human | Esophagus | ESCC | 1.21e-10 | 1.47e-01 | 0.0811 |
6638 | SNRPN | LZE20T | Human | Esophagus | ESCC | 2.18e-05 | 4.50e-02 | 0.0662 |
6638 | SNRPN | LZE24T | Human | Esophagus | ESCC | 3.49e-02 | -1.34e-01 | 0.0596 |
6638 | SNRPN | P2T-E | Human | Esophagus | ESCC | 1.65e-24 | 1.58e-01 | 0.1177 |
6638 | SNRPN | P4T-E | Human | Esophagus | ESCC | 2.28e-27 | 6.58e-01 | 0.1323 |
6638 | SNRPN | P5T-E | Human | Esophagus | ESCC | 1.23e-08 | 1.68e-02 | 0.1327 |
6638 | SNRPN | P8T-E | Human | Esophagus | ESCC | 5.12e-35 | 5.41e-01 | 0.0889 |
6638 | SNRPN | P9T-E | Human | Esophagus | ESCC | 1.44e-16 | 3.35e-01 | 0.1131 |
6638 | SNRPN | P10T-E | Human | Esophagus | ESCC | 1.14e-74 | 1.40e+00 | 0.116 |
6638 | SNRPN | P12T-E | Human | Esophagus | ESCC | 4.58e-49 | 9.95e-01 | 0.1122 |
6638 | SNRPN | P15T-E | Human | Esophagus | ESCC | 5.79e-09 | 1.43e-01 | 0.1149 |
6638 | SNRPN | P16T-E | Human | Esophagus | ESCC | 4.63e-28 | 6.91e-01 | 0.1153 |
6638 | SNRPN | P19T-E | Human | Esophagus | ESCC | 8.67e-05 | 7.23e-01 | 0.1662 |
6638 | SNRPN | P21T-E | Human | Esophagus | ESCC | 1.36e-22 | 2.18e-01 | 0.1617 |
6638 | SNRPN | P22T-E | Human | Esophagus | ESCC | 1.72e-61 | 1.13e+00 | 0.1236 |
6638 | SNRPN | P24T-E | Human | Esophagus | ESCC | 3.74e-04 | -5.98e-02 | 0.1287 |
6638 | SNRPN | P26T-E | Human | Esophagus | ESCC | 5.56e-04 | -2.65e-01 | 0.1276 |
6638 | SNRPN | P27T-E | Human | Esophagus | ESCC | 2.41e-34 | 6.32e-01 | 0.1055 |
6638 | SNRPN | P28T-E | Human | Esophagus | ESCC | 5.88e-08 | 1.50e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRPN | SNV | Missense_Mutation | c.377N>T | p.Gly126Val | p.G126V | P63162 | protein_coding | deleterious(0.05) | possibly_damaging(0.788) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
SNRPN | SNV | Missense_Mutation | novel | c.40N>A | p.Asp14Asn | p.D14N | P63162 | protein_coding | tolerated(1) | benign(0.03) | TCGA-DC-4745-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
SNRPN | deletion | Frame_Shift_Del | c.668delC | p.Pro223LeufsTer39 | p.P223Lfs*39 | P63162 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |||
SNRPN | SNV | Missense_Mutation | c.114N>T | p.Met38Ile | p.M38I | P63162 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNRPN | SNV | Missense_Mutation | novel | c.662N>T | p.Arg221Ile | p.R221I | P63162 | protein_coding | deleterious_low_confidence(0.02) | benign(0.367) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNRPN | SNV | Missense_Mutation | c.114N>T | p.Met38Ile | p.M38I | P63162 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPN | SNV | Missense_Mutation | c.529N>T | p.Pro177Ser | p.P177S | P63162 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPN | SNV | Missense_Mutation | rs764893207 | c.632N>T | p.Thr211Met | p.T211M | P63162 | protein_coding | deleterious(0) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNRPN | SNV | Missense_Mutation | novel | c.451G>T | p.Ala151Ser | p.A151S | P63162 | protein_coding | tolerated(0.33) | probably_damaging(0.968) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SNRPN | SNV | Missense_Mutation | rs755610165 | c.218G>A | p.Arg73His | p.R73H | P63162 | protein_coding | tolerated(0.06) | benign(0.283) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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