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Gene: SNAI2 |
Gene summary for SNAI2 |
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Gene information | Species | Human | Gene symbol | SNAI2 | Gene ID | 6591 |
Gene name | snail family transcriptional repressor 2 | |
Gene Alias | SLUG | |
Cytomap | 8q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O43623 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6591 | SNAI2 | LZE4T | Human | Esophagus | ESCC | 7.04e-08 | 5.18e-01 | 0.0811 |
6591 | SNAI2 | P2T-E | Human | Esophagus | ESCC | 8.09e-25 | 6.78e-01 | 0.1177 |
6591 | SNAI2 | P4T-E | Human | Esophagus | ESCC | 2.85e-06 | 4.37e-01 | 0.1323 |
6591 | SNAI2 | P5T-E | Human | Esophagus | ESCC | 1.69e-14 | 3.65e-01 | 0.1327 |
6591 | SNAI2 | P8T-E | Human | Esophagus | ESCC | 7.07e-03 | -1.94e-02 | 0.0889 |
6591 | SNAI2 | P9T-E | Human | Esophagus | ESCC | 4.77e-13 | 6.01e-01 | 0.1131 |
6591 | SNAI2 | P10T-E | Human | Esophagus | ESCC | 2.78e-26 | 7.35e-01 | 0.116 |
6591 | SNAI2 | P11T-E | Human | Esophagus | ESCC | 4.46e-06 | 1.04e+00 | 0.1426 |
6591 | SNAI2 | P12T-E | Human | Esophagus | ESCC | 3.92e-11 | 5.65e-01 | 0.1122 |
6591 | SNAI2 | P15T-E | Human | Esophagus | ESCC | 1.80e-18 | 7.42e-01 | 0.1149 |
6591 | SNAI2 | P16T-E | Human | Esophagus | ESCC | 1.49e-41 | 1.16e+00 | 0.1153 |
6591 | SNAI2 | P20T-E | Human | Esophagus | ESCC | 7.73e-19 | 7.65e-01 | 0.1124 |
6591 | SNAI2 | P21T-E | Human | Esophagus | ESCC | 3.58e-26 | 1.07e+00 | 0.1617 |
6591 | SNAI2 | P22T-E | Human | Esophagus | ESCC | 1.94e-34 | 9.31e-01 | 0.1236 |
6591 | SNAI2 | P23T-E | Human | Esophagus | ESCC | 6.10e-10 | 8.17e-01 | 0.108 |
6591 | SNAI2 | P26T-E | Human | Esophagus | ESCC | 2.56e-26 | 8.40e-01 | 0.1276 |
6591 | SNAI2 | P27T-E | Human | Esophagus | ESCC | 3.40e-14 | 3.81e-01 | 0.1055 |
6591 | SNAI2 | P28T-E | Human | Esophagus | ESCC | 4.22e-07 | 3.55e-01 | 0.1149 |
6591 | SNAI2 | P30T-E | Human | Esophagus | ESCC | 8.36e-41 | 2.05e+00 | 0.137 |
6591 | SNAI2 | P31T-E | Human | Esophagus | ESCC | 3.75e-24 | 7.89e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:2001236111 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway | 111/8552 | 151/18723 | 2.97e-12 | 1.18e-10 | 111 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0008630110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to DNA damage | 78/8552 | 99/18723 | 1.43e-11 | 5.08e-10 | 78 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:1901796111 | Esophagus | ESCC | regulation of signal transduction by p53 class mediator | 70/8552 | 93/18723 | 5.69e-09 | 1.18e-07 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0452029 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa04520113 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439010 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa04520112 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439015 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa0452028 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439024 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
hsa0452036 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439034 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNAI2 | SNV | Missense_Mutation | novel | c.118N>T | p.Pro40Ser | p.P40S | O43623 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SNAI2 | SNV | Missense_Mutation | c.682C>A | p.Leu228Met | p.L228M | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SNAI2 | SNV | Missense_Mutation | novel | c.127N>T | p.Pro43Ser | p.P43S | O43623 | protein_coding | tolerated(0.1) | possibly_damaging(0.727) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | c.523A>G | p.Lys175Glu | p.K175E | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A163-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD | |
SNAI2 | SNV | Missense_Mutation | rs763952937 | c.34N>G | p.Asn12Asp | p.N12D | O43623 | protein_coding | tolerated(0.09) | benign(0.152) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | c.453C>G | p.Cys151Trp | p.C151W | O43623 | protein_coding | deleterious(0.02) | benign(0.328) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SNAI2 | SNV | Missense_Mutation | c.349N>A | p.Leu117Ile | p.L117I | O43623 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
SNAI2 | SNV | Missense_Mutation | c.290N>T | p.Lys97Met | p.K97M | O43623 | protein_coding | tolerated(0.11) | benign(0.258) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SNAI2 | SNV | Missense_Mutation | c.213N>A | p.Asn71Lys | p.N71K | O43623 | protein_coding | tolerated(0.88) | benign(0) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNAI2 | SNV | Missense_Mutation | novel | c.535C>T | p.Arg179Trp | p.R179W | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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