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Gene: SMIM10 |
Gene summary for SMIM10 |
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Gene information | Species | Human | Gene symbol | SMIM10 | Gene ID | 644538 |
Gene name | small integral membrane protein 10 | |
Gene Alias | CXorf69 | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P0DMW3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
644538 | SMIM10 | ATC13 | Human | Thyroid | ATC | 2.32e-20 | 5.34e-01 | 0.34 |
644538 | SMIM10 | ATC2 | Human | Thyroid | ATC | 5.21e-08 | 8.98e-01 | 0.34 |
644538 | SMIM10 | ATC5 | Human | Thyroid | ATC | 6.28e-28 | 6.04e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM10 | SNV | Missense_Mutation | c.192N>A | p.Phe64Leu | p.F64L | Q96HG1,P0DMW3 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SMIM10 | SNV | Missense_Mutation | novel | c.113N>A | p.Ser38Tyr | p.S38Y | Q96HG1,P0DMW3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMIM10 | SNV | Missense_Mutation | c.186G>C | p.Lys62Asn | p.K62N | Q96HG1,P0DMW3 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-2Y-A9GU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SMIM10 | SNV | Missense_Mutation | novel | c.91N>A | p.Arg31Ser | p.R31S | Q96HG1,P0DMW3 | protein_coding | tolerated(0.35) | benign(0.089) | TCGA-ZP-A9CV-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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