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Gene: SLCO4A1 |
Gene summary for SLCO4A1 |
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Gene information | Species | Human | Gene symbol | SLCO4A1 | Gene ID | 28231 |
Gene name | solute carrier organic anion transporter family member 4A1 | |
Gene Alias | OATP-E | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q96BD0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28231 | SLCO4A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.37e-05 | 2.39e-01 | -0.059 |
28231 | SLCO4A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.58e-04 | 2.36e-01 | 0.096 |
28231 | SLCO4A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.19e-05 | 2.26e-01 | 0.0674 |
28231 | SLCO4A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.24e-05 | 2.52e-01 | 0.294 |
28231 | SLCO4A1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.79e-02 | 5.33e-01 | 0.3487 |
28231 | SLCO4A1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.73e-34 | 8.65e-01 | 0.3859 |
28231 | SLCO4A1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.06e-07 | 6.28e-01 | 0.2585 |
28231 | SLCO4A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.14e-02 | 1.61e-01 | 0.3005 |
28231 | SLCO4A1 | LZE6T | Human | Esophagus | ESCC | 5.38e-03 | 2.26e-01 | 0.0845 |
28231 | SLCO4A1 | P5T-E | Human | Esophagus | ESCC | 1.46e-03 | 7.31e-02 | 0.1327 |
28231 | SLCO4A1 | P21T-E | Human | Esophagus | ESCC | 5.19e-25 | 6.43e-01 | 0.1617 |
28231 | SLCO4A1 | P23T-E | Human | Esophagus | ESCC | 4.84e-02 | 3.41e-01 | 0.108 |
28231 | SLCO4A1 | P26T-E | Human | Esophagus | ESCC | 7.35e-05 | 3.64e-02 | 0.1276 |
28231 | SLCO4A1 | P28T-E | Human | Esophagus | ESCC | 1.99e-09 | 1.76e-01 | 0.1149 |
28231 | SLCO4A1 | P37T-E | Human | Esophagus | ESCC | 1.44e-02 | 1.29e-01 | 0.1371 |
28231 | SLCO4A1 | P39T-E | Human | Esophagus | ESCC | 3.95e-02 | 1.43e-01 | 0.0894 |
28231 | SLCO4A1 | P62T-E | Human | Esophagus | ESCC | 2.55e-06 | 5.11e-01 | 0.1302 |
28231 | SLCO4A1 | P74T-E | Human | Esophagus | ESCC | 3.69e-02 | 9.91e-02 | 0.1479 |
28231 | SLCO4A1 | P75T-E | Human | Esophagus | ESCC | 1.06e-05 | 1.68e-01 | 0.1125 |
28231 | SLCO4A1 | P76T-E | Human | Esophagus | ESCC | 1.65e-06 | 2.23e-01 | 0.1207 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO4A1 | SNV | Missense_Mutation | c.1529N>A | p.Cys510Tyr | p.C510Y | Q96BD0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
SLCO4A1 | SNV | Missense_Mutation | novel | c.1958N>T | p.Gly653Val | p.G653V | Q96BD0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLCO4A1 | SNV | Missense_Mutation | c.1832N>A | p.Arg611Lys | p.R611K | Q96BD0 | protein_coding | tolerated(0.12) | benign(0.232) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLCO4A1 | SNV | Missense_Mutation | c.1873N>G | p.Leu625Val | p.L625V | Q96BD0 | protein_coding | deleterious(0.03) | possibly_damaging(0.838) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLCO4A1 | SNV | Missense_Mutation | rs368075379 | c.1820N>A | p.Arg607His | p.R607H | Q96BD0 | protein_coding | tolerated(0.64) | benign(0.022) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLCO4A1 | SNV | Missense_Mutation | rs567670164 | c.650N>T | p.Ala217Val | p.A217V | Q96BD0 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-CM-5862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLCO4A1 | SNV | Missense_Mutation | c.1497N>A | p.Asn499Lys | p.N499K | Q96BD0 | protein_coding | tolerated(0.13) | benign(0.314) | TCGA-DM-A28G-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLCO4A1 | SNV | Missense_Mutation | c.1747N>A | p.Phe583Ile | p.F583I | Q96BD0 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLCO4A1 | SNV | Missense_Mutation | c.556N>A | p.Val186Met | p.V186M | Q96BD0 | protein_coding | deleterious(0.03) | benign(0.386) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLCO4A1 | SNV | Missense_Mutation | c.369N>A | p.Phe123Leu | p.F123L | Q96BD0 | protein_coding | tolerated(0.24) | benign(0.026) | TCGA-G5-6235-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
28231 | SLCO4A1 | DRUGGABLE GENOME, TRANSPORTER | 178101458 |
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